Characteristics, consent patterns, and challenges of randomized trials using the Trials within Cohorts (TwiCs) design - A scoping review

• Published in: Journal of clinical epidemiology Vol. 174; p. 111469
• Main Authors: Amstutz, Alain, Schönenberger, Christof M., Speich, Benjamin, Griessbach, Alexandra, Schwenke, Johannes M., Glasstetter, Jan, James, Sophie, Verkooijen, Helena M., Nickolls, Beverley, Relton, Clare, Hemkens, Lars G., Chammartin, Frédérique, Gerber, Felix, Labhardt, Niklaus D., Schandelmaier, Stefan, Briel, Matthias
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2024; Elsevier Limited
• Subjects: Clinical trials; cmRCT; Cohort analysis; Cohort Studies; Confidence intervals; Consent; Consents; Data collection; Design; Feasibility studies; Humans; Infectious diseases; Informed consent; Informed Consent - statistics & numerical data; Intervention; Medical research; Metaresearch; Randomization; Randomized clinical trial; Randomized Controlled Trials as Topic - methods; Research Design; Trial design; Trials within cohorts; TwiCs; TwiCs; Randomized clinical trial; Metaresearch; cmRCT; Trial design; Trials within cohorts

Trials within Cohorts (TwiCs) is a pragmatic design approach that may overcome frequent challenges of traditional randomized trials such as slow recruitment, burdensome consent procedures, or limited external validity. This scoping review aims to identify all randomized controlled trials using the T...