Characteristics, consent patterns, and challenges of randomized trials using the Trials within Cohorts (TwiCs) design - A scoping review
Trials within Cohorts (TwiCs) is a pragmatic design approach that may overcome frequent challenges of traditional randomized trials such as slow recruitment, burdensome consent procedures, or limited external validity. This scoping review aims to identify all randomized controlled trials using the T...
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Published in | Journal of clinical epidemiology Vol. 174; p. 111469 |
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Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Elsevier Inc
01.10.2024
Elsevier Limited |
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Abstract | Trials within Cohorts (TwiCs) is a pragmatic design approach that may overcome frequent challenges of traditional randomized trials such as slow recruitment, burdensome consent procedures, or limited external validity. This scoping review aims to identify all randomized controlled trials using the TwiCs design and to summarize their design characteristics, ways to obtain informed consent, output, reported challenges and mitigation strategies.
Systematic search of Medline, Embase, Cochrane, trial registries and citation tracking up to December 2022. TwiCs were defined as randomized trials embedded in a cohort with postrandomization consent for the intervention group and no specific postrandomization consent for the usual care control group. Information from identified TwiCs was extracted in duplicate from protocols, publications, and registry entries. We analyzed the information descriptively and qualitatively to highlight methodological challenges and solutions related to nonuptake of interventions and informed consent procedure.
We identified a total of 46 TwiCs conducted between 2005 and 2022 in 14 different countries by a handful of research groups. The most common medical fields were oncology (11/46; 24%), infectious diseases (8/46; 17%), and mental health (7/46; 15%). A typical TwiCs was investigator-initiated (46/46; 100%), publicly funded (36/46; 78%), and recruited outpatients (27/46; 59%). Excluding eight pilot trials, only 16/38 (42%) TwiCs adjusted their calculated sample size for nonuptake of the intervention, anticipating a median nonuptake of 25% (interquartile range 10%-32%) in the experimental arm. Seventeen TwiCs (45%) planned analyses to adjust effect estimates for nonuptake. Regarding informed consent, we observed three patterns: 1) three separate consents for cohort participation, randomization, and intervention (17/46; 37%); 2) combined consent for cohort participation and randomization and a separate intervention consent (10/46; 22%); and 3) consent only for cohort participation and intervention (randomization consent not mentioned; 19/46; 41%).
Existing TwiCs are globally scattered across a few research groups covering a wide range of medical fields and interventions. Despite the potential advantages, the number of TwiCs remains small. The variability in consent procedures and the possibility of substantial nonuptake of the intervention warrants further research to guide the planning, implementation, and analysis of TwiCs. |
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AbstractList | ObjectivesTrials within Cohorts (TwiCs) is a pragmatic design approach that may overcome frequent challenges of traditional randomized trials such as slow recruitment, burdensome consent procedures, or limited external validity. This scoping review aims to identify all randomized controlled trials using the TwiCs design and to summarize their design characteristics, ways to obtain informed consent, output, reported challenges and mitigation strategies.Study Design and SettingSystematic search of Medline, Embase, Cochrane, trial registries and citation tracking up to December 2022. TwiCs were defined as randomized trials embedded in a cohort with postrandomization consent for the intervention group and no specific postrandomization consent for the usual care control group. Information from identified TwiCs was extracted in duplicate from protocols, publications, and registry entries. We analyzed the information descriptively and qualitatively to highlight methodological challenges and solutions related to nonuptake of interventions and informed consent procedure.ResultsWe identified a total of 46 TwiCs conducted between 2005 and 2022 in 14 different countries by a handful of research groups. The most common medical fields were oncology (11/46; 24%), infectious diseases (8/46; 17%), and mental health (7/46; 15%). A typical TwiCs was investigator-initiated (46/46; 100%), publicly funded (36/46; 78%), and recruited outpatients (27/46; 59%). Excluding eight pilot trials, only 16/38 (42%) TwiCs adjusted their calculated sample size for nonuptake of the intervention, anticipating a median nonuptake of 25% (interquartile range 10%-32%) in the experimental arm. Seventeen TwiCs (45%) planned analyses to adjust effect estimates for nonuptake. Regarding informed consent, we observed three patterns: 1) three separate consents for cohort participation, randomization, and intervention (17/46; 37%); 2) combined consent for cohort participation and randomization and a separate intervention consent (10/46; 22%); and 3) consent only for cohort participation and intervention (randomization consent not mentioned; 19/46; 41%).ConclusionExisting TwiCs are globally scattered across a few research groups covering a wide range of medical fields and interventions. Despite the potential advantages, the number of TwiCs remains small. The variability in consent procedures and the possibility of substantial nonuptake of the intervention warrants further research to guide the planning, implementation, and analysis of TwiCs. Trials within Cohorts (TwiCs) is a pragmatic design approach that may overcome frequent challenges of traditional randomized trials such as slow recruitment, burdensome consent procedures, or limited external validity. This scoping review aims to identify all randomized controlled trials using the TwiCs design and to summarize their design characteristics, ways to obtain informed consent, output, reported challenges and mitigation strategies. Systematic search of Medline, Embase, Cochrane, trial registries and citation tracking up to December 2022. TwiCs were defined as randomized trials embedded in a cohort with postrandomization consent for the intervention group and no specific postrandomization consent for the usual care control group. Information from identified TwiCs was extracted in duplicate from protocols, publications, and registry entries. We analyzed the information descriptively and qualitatively to highlight methodological challenges and solutions related to nonuptake of interventions and informed consent procedure. We identified a total of 46 TwiCs conducted between 2005 and 2022 in 14 different countries by a handful of research groups. The most common medical fields were oncology (11/46; 24%), infectious diseases (8/46; 17%), and mental health (7/46; 15%). A typical TwiCs was investigator-initiated (46/46; 100%), publicly funded (36/46; 78%), and recruited outpatients (27/46; 59%). Excluding eight pilot trials, only 16/38 (42%) TwiCs adjusted their calculated sample size for nonuptake of the intervention, anticipating a median nonuptake of 25% (interquartile range 10%-32%) in the experimental arm. Seventeen TwiCs (45%) planned analyses to adjust effect estimates for nonuptake. Regarding informed consent, we observed three patterns: 1) three separate consents for cohort participation, randomization, and intervention (17/46; 37%); 2) combined consent for cohort participation and randomization and a separate intervention consent (10/46; 22%); and 3) consent only for cohort participation and intervention (randomization consent not mentioned; 19/46; 41%). Existing TwiCs are globally scattered across a few research groups covering a wide range of medical fields and interventions. Despite the potential advantages, the number of TwiCs remains small. The variability in consent procedures and the possibility of substantial nonuptake of the intervention warrants further research to guide the planning, implementation, and analysis of TwiCs. Trials within Cohorts (TwiCs) is a pragmatic design approach that may overcome frequent challenges of traditional randomized trials such as slow recruitment, burdensome consent procedures, or limited external validity. This scoping review aims to identify all randomized controlled trials using the TwiCs design and to summarize their design characteristics, ways to obtain informed consent, output, reported challenges and mitigation strategies.OBJECTIVESTrials within Cohorts (TwiCs) is a pragmatic design approach that may overcome frequent challenges of traditional randomized trials such as slow recruitment, burdensome consent procedures, or limited external validity. This scoping review aims to identify all randomized controlled trials using the TwiCs design and to summarize their design characteristics, ways to obtain informed consent, output, reported challenges and mitigation strategies.Systematic search of Medline, Embase, Cochrane, trial registries and citation tracking up to December 2022. TwiCs were defined as randomized trials embedded in a cohort with postrandomization consent for the intervention group and no specific postrandomization consent for the usual care control group. Information from identified TwiCs was extracted in duplicate from protocols, publications, and registry entries. We analyzed the information descriptively and qualitatively to highlight methodological challenges and solutions related to nonuptake of interventions and informed consent procedure.STUDY DESIGN AND SETTINGSystematic search of Medline, Embase, Cochrane, trial registries and citation tracking up to December 2022. TwiCs were defined as randomized trials embedded in a cohort with postrandomization consent for the intervention group and no specific postrandomization consent for the usual care control group. Information from identified TwiCs was extracted in duplicate from protocols, publications, and registry entries. We analyzed the information descriptively and qualitatively to highlight methodological challenges and solutions related to nonuptake of interventions and informed consent procedure.We identified a total of 46 TwiCs conducted between 2005 and 2022 in 14 different countries by a handful of research groups. The most common medical fields were oncology (11/46; 24%), infectious diseases (8/46; 17%), and mental health (7/46; 15%). A typical TwiCs was investigator-initiated (46/46; 100%), publicly funded (36/46; 78%), and recruited outpatients (27/46; 59%). Excluding eight pilot trials, only 16/38 (42%) TwiCs adjusted their calculated sample size for nonuptake of the intervention, anticipating a median nonuptake of 25% (interquartile range 10%-32%) in the experimental arm. Seventeen TwiCs (45%) planned analyses to adjust effect estimates for nonuptake. Regarding informed consent, we observed three patterns: 1) three separate consents for cohort participation, randomization, and intervention (17/46; 37%); 2) combined consent for cohort participation and randomization and a separate intervention consent (10/46; 22%); and 3) consent only for cohort participation and intervention (randomization consent not mentioned; 19/46; 41%).RESULTSWe identified a total of 46 TwiCs conducted between 2005 and 2022 in 14 different countries by a handful of research groups. The most common medical fields were oncology (11/46; 24%), infectious diseases (8/46; 17%), and mental health (7/46; 15%). A typical TwiCs was investigator-initiated (46/46; 100%), publicly funded (36/46; 78%), and recruited outpatients (27/46; 59%). Excluding eight pilot trials, only 16/38 (42%) TwiCs adjusted their calculated sample size for nonuptake of the intervention, anticipating a median nonuptake of 25% (interquartile range 10%-32%) in the experimental arm. Seventeen TwiCs (45%) planned analyses to adjust effect estimates for nonuptake. Regarding informed consent, we observed three patterns: 1) three separate consents for cohort participation, randomization, and intervention (17/46; 37%); 2) combined consent for cohort participation and randomization and a separate intervention consent (10/46; 22%); and 3) consent only for cohort participation and intervention (randomization consent not mentioned; 19/46; 41%).Existing TwiCs are globally scattered across a few research groups covering a wide range of medical fields and interventions. Despite the potential advantages, the number of TwiCs remains small. The variability in consent procedures and the possibility of substantial nonuptake of the intervention warrants further research to guide the planning, implementation, and analysis of TwiCs.CONCLUSIONExisting TwiCs are globally scattered across a few research groups covering a wide range of medical fields and interventions. Despite the potential advantages, the number of TwiCs remains small. The variability in consent procedures and the possibility of substantial nonuptake of the intervention warrants further research to guide the planning, implementation, and analysis of TwiCs. |
ArticleNumber | 111469 |
Author | Speich, Benjamin Amstutz, Alain Hemkens, Lars G. Chammartin, Frédérique Griessbach, Alexandra Verkooijen, Helena M. Schwenke, Johannes M. Schandelmaier, Stefan Relton, Clare Gerber, Felix Briel, Matthias Nickolls, Beverley Schönenberger, Christof M. Labhardt, Niklaus D. James, Sophie Glasstetter, Jan |
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Cites_doi | 10.1177/1740774517746620 10.1016/j.eclinm.2022.101362 10.1186/1745-6215-7-9 10.1016/j.homp.2014.05.001 10.1177/1740774517746610 10.1016/j.ijrobp.2020.06.013 10.1186/s12982-018-0069-7 10.1016/j.jclinepi.2022.04.015 10.1136/bmj.c1066 10.1016/0021-9681(67)90041-0 10.1371/journal.pmed.1003980 10.1001/jamainternmed.2020.6820 10.1136/bmjmed-2022-000427 10.1186/s12874-020-01107-7 10.1016/j.jbi.2019.103208 10.1186/1745-6215-10-37 10.7326/M18-0850 10.1016/j.jclinepi.2019.05.017 10.1037/met0000013 10.1186/s12874-016-0208-1 10.1016/j.ijrobp.2020.11.060 10.1186/s12885-020-07252-y 10.1007/s10549-021-06363-9 10.1007/s11121-008-0104-y 10.1186/s12889-018-6300-1 10.1186/s12916-018-1051-5 10.1016/j.jclinepi.2022.04.017 10.1136/bmjopen-2020-044045 10.1016/j.jclinepi.2017.12.008 10.1001/jamaoncol.2023.6776 10.1186/s13063-024-08226-2 10.1016/S2665-9913(21)00315-5 10.1016/j.jclinepi.2020.10.015 10.1016/j.eururo.2023.07.012 10.1056/NEJMp1005843 10.1007/s00431-019-03374-z 10.1097/EDE.0000000000000469 10.3310/hta25460 10.1016/j.jsp.2015.12.006 10.1002/acr.23098 10.1186/s12885-022-10419-4 10.1186/s13063-023-07729-8 10.1177/17407745231185058 10.1136/bmjopen-2023-075601 10.1016/S2213-2600(20)30556-7 10.1038/s41416-020-0866-y 10.1016/j.jclinepi.2019.12.015 10.1056/NEJMra1510059 10.1097/EDE.0000000000000435 10.1136/ebmed-2016-110401 10.1371/journal.pone.0168712 10.1080/20008066.2023.2179569 10.4103/picr.PICR_106_18 10.1016/j.cct.2012.04.003 10.1136/bmj.d5928 10.1016/j.invent.2022.100582 10.1186/s40814-022-01156-3 10.1503/cmaj.051625 10.31887/DCNS.2011.13.2/npatsopoulos 10.1136/bmjopen-2016-014730 10.1056/NEJM197905313002203 10.1186/s13063-023-07315-y 10.1093/rheumatology/kez368 10.1017/cem.2019.406 10.1016/j.jbi.2008.08.010 10.1097/j.pain.0000000000001198 10.1093/bjs/znac249 10.1093/gerona/glaa325 10.1186/s13063-017-2040-2 |
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Keywords | TwiCs Randomized clinical trial Metaresearch cmRCT Trial design Trials within cohorts |
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References | Doppenberg, Besselink, van Eijck, Intven, Koerkamp, Kazemier (bib47) 2022; 22 Fahim, Couwenberg, Verweij, Dijksman, Verkooijen, Smits (bib53) 2022; 109 Young-Afat, Verkooijen, van Gils, van der Velden, Burbach, Elias (bib12) 2016; 27 Touzet, Occelli, Schröder, Manificat, Gicquel, Stanciu (bib42) 2017; 7 Treweek, Zwarenstein (bib5) 2009; 10 Harris, Taylor, Minor, Elliott, Fernandez, O'Neal (bib21) 2019; 95 van der Velden, Verkooijen, Young-Afat, Burbach, van Vulpen, Relton (bib9) 2017; 46 Cockayne, Adamson, Clarke, Corbacho, Fairhurst, Green (bib51) 2017; 12 Hermine, Mariette, Porcher, Djossou, Nguyen, Arlet (bib36) 2022; 46 Gal, Monninkhof, van Gils, Groenwold, Elias, van den Bongard (bib56) 2021; 190 Schwartz, Lellouch (bib7) 1967; 20 (bib27) 2022 Verweij, Gal, Burbach, Young-Afat, van der Velden, van der Graaf (bib74) 2022; 148 Schraa, Van Rooijen, Van Der Kruijssen, Rubio Alarcón, Phallen, Sausen (bib45) 2020; 20 Gerber, Gupta, Lejone, Tahirsylaj, Lee, Sanchez-Samaniego (bib68) 2024; 25 Relton, Torgerson, O'Cathain, Nicholl (bib10) 2010; 340 Panagioti, Reeves, Meacock, Parkinson, Lovell, Hann (bib49) 2018; 16 Anderson, Dutton, Day, Jackson, Ferro, Sharif (bib39) 2018; 19 Mink van der Molen, Batenburg, Maarse, van den Bongard, Doeksen, de Lange (bib40) 2024; 10 Harris, Taylor, Thielke, Payne, Gonzalez, Conde (bib22) 2009; 42 Rombach, Tucker, Tillett, Jadon, Watson, Francis (bib48) 2021; 13 Cockayne, Adamson, Fairhurst, Crossland, Drummond, Drummond (bib62) 2021; 25 Pielkenrood, van der Velden, van der Linden, Bartels, Kasperts, Verhoeff (bib57) 2021; 110 Stuart, Perry, Le, Ialongo (bib79) 2008; 9 Couwenberg, Burbach, May, Berbee, Intven, Verkooijen (bib83) 2020; 120 Mariette, Perrodeau, Verner, Struillou, Picard, Schaeverbeke (bib32) 2020; 59 (bib33) 2021; 9 Sagarin, West, Ratnikov, Homan, Ritchie, Hansen (bib78) 2014; 19 Engelmann, Lowe, Husing (bib43) 2022; 30 Relton, O'Cathain, Nicholl (bib41) 2012; 33 Lousdal (bib80) 2018; 15 Colagiuri, Sharpe, Ambarchi, Glozier, Bartlett, Costa (bib46) 2021; 11 Peugh, Strotman, McGrady, Rausch, Kashikar-Zuck (bib16) 2017; 60 Williams, Wiggers, O'Brien, Wolfenden, Yoong, Hodder (bib28) 2018; 159 Koutoukidis, Land, Hackshaw, Heinrich, McCourt, Beeken (bib70) 2020; 123 Snider, Jiang, Logsetty, Chernomas, Mordoch, Cochrane (bib60) 2020; 22 Vickers, Vertosick, Austria, Gaffney, Carlsson, Kim (bib66) 2023; 20 Higgins, Altman, Gøtzsche, Juni, Moher, Oxman (bib76) 2011; 343 Konwar, Bose, Gogtay, Thatte (bib69) 2018; 9 Kim, Flory, Relton (bib13) 2018; 15 Fibert, Peasgood, Relton (bib54) 2019; 178 Gerber, Gupta, Lejone, Tahirsylaj, Lee, Kohler (bib67) 2023; 24 Peckham, Relton, Raw, Walters, Thomas, Smith (bib61) 2014; 103 Jongbloed, Friedman, Pearce, Van Der Kop, Thomas, Demerais (bib58) 2016; 17 Kwakkenbos, Carrier, Welling, Levis, Levis, Sauve (bib52) 2022; 23 Neves, Warren, Santiapillai, Rode, Cullen, Pavlou (bib26) 2024; 85 Lacombe, Hueso, Porcher, Mekinian, Chiarabini, Georgin-Lavialle (bib25) 2023; 2 (bib29) 2022 Patsopoulos (bib75) 2011; 13 Zelen (bib71) 1979; 300 Vickers, Young-Afat, Ehdaie, Kim (bib11) 2018; 15 Caille, Allemang-Trivalle, Blanchin, Rebion, Sauvaget, Gohier (bib64) 2023; 14 Mbuagbaw, Lawson, Puljak, Allison, Thabane (bib18) 2020; 20 Jolliffe, Holt, Greenig, Talaei, Perdek, Pfeffer (bib37) 2022; 378 Viksveen, Relton, Nicholl (bib38) 2017; 18 Young-Afat, Gal, Gerlich, Burbach, van der Velden, van den Bongard (bib73) 2021; 130 McDonald, Knight, Campbell, Entwistle, Grant, Cook (bib4) 2006; 7 Pate, Candlish, Sperrin, Van Staa (bib14) 2016; 16 O'Brien, Van Dongen, Williams, Kamper, Wiggers, Hodder (bib24) 2018; 18 Stefanick, King, Mackey, Tinker, Hlatky, LaMonte (bib59) 2021; 76 Young (bib3) 2010; 363 Tricco, Lillie, Zarin, O'Brien, Colquhoun, Levac (bib17) 2018; 169 (bib34) 2022; 4 Howick, Koletsi, Ioannidis, Madigan, Pandis, Loef (bib82) 2022; 148 Nickolls, Relton, Hemkens, Zwarenstein, Eldridge, McCall (bib85) 2024; 14 Gal, Monninkhof, van Gils, Groenwold, van den Bongard, Peeters (bib84) 2019; 113 Murad, Asi, Alsawas, Alahdab (bib2) 2016; 21 Couwenberg, Burbach, Berbee, Lacle, Arensman, Raicu (bib50) 2020; 108 Koutoukidis, Land, Hackshaw, Heinrich, McCourt, Beeken (bib44) 2020; 123 van Goor, Daamen, Besselink, Bruynzeel, Busch, Cirkel (bib31) 2022; 23 Speich, Gryaznov, Busse, Gloy, Lohner, Klatte (bib6) 2022; 19 Reeves, Howells, Sidaway, Blakemore, Hann, Panagioti (bib15) Mar 2018; 95 Huele, van der Velden, Kasperts, Eppinga, Grutters, Suelmann (bib65) 2023; 24 bib23 Amstutz, Schoenenberger, Speich, Schandelmaier, Griessbach, James (bib19) 2022 Hermine, Mariette, Tharaux, Resche-Rigon, Porcher, Ravaud (bib35) 2021; 181 Lacombe, Hueso, Porcher, Mekinian, Chiarabini, Georgin-Lavialle (bib77) 2022 bib20 Bibby, Zahan-Evans, Keenan, Comins, Harvey, Day (bib55) 2022; 8 Fisher, Wishart (bib1) 1930 Ford, Norrie (bib8) 2016; 375 Loberg, Kalager, Bretthauer (bib72) 2016; 27 Hewitt, Torgerson, Miles (bib81) 2006; 175 (bib30) 2022 Rannou, Boutron, Mouthon, Sanchez, Tiffreau, Hachulla (bib63) 2017; 69 Jolliffe (10.1016/j.jclinepi.2024.111469_bib37) 2022; 378 McDonald (10.1016/j.jclinepi.2024.111469_bib4) 2006; 7 Young (10.1016/j.jclinepi.2024.111469_bib3) 2010; 363 Gerber (10.1016/j.jclinepi.2024.111469_bib68) 2024; 25 Relton (10.1016/j.jclinepi.2024.111469_bib41) 2012; 33 Patsopoulos (10.1016/j.jclinepi.2024.111469_bib75) 2011; 13 (10.1016/j.jclinepi.2024.111469_bib34) 2022; 4 Hewitt (10.1016/j.jclinepi.2024.111469_bib81) 2006; 175 Harris (10.1016/j.jclinepi.2024.111469_bib21) 2019; 95 Panagioti (10.1016/j.jclinepi.2024.111469_bib49) 2018; 16 Treweek (10.1016/j.jclinepi.2024.111469_bib5) 2009; 10 Hermine (10.1016/j.jclinepi.2024.111469_bib36) 2022; 46 Lacombe (10.1016/j.jclinepi.2024.111469_bib77) 2022 Peugh (10.1016/j.jclinepi.2024.111469_bib16) 2017; 60 Pielkenrood (10.1016/j.jclinepi.2024.111469_bib57) 2021; 110 Howick (10.1016/j.jclinepi.2024.111469_bib82) 2022; 148 Young-Afat (10.1016/j.jclinepi.2024.111469_bib12) 2016; 27 Murad (10.1016/j.jclinepi.2024.111469_bib2) 2016; 21 Hermine (10.1016/j.jclinepi.2024.111469_bib35) 2021; 181 Loberg (10.1016/j.jclinepi.2024.111469_bib72) 2016; 27 Mbuagbaw (10.1016/j.jclinepi.2024.111469_bib18) 2020; 20 Neves (10.1016/j.jclinepi.2024.111469_bib26) 2024; 85 Zelen (10.1016/j.jclinepi.2024.111469_bib71) 1979; 300 Lacombe (10.1016/j.jclinepi.2024.111469_bib25) 2023; 2 van Goor (10.1016/j.jclinepi.2024.111469_bib31) 2022; 23 Rombach (10.1016/j.jclinepi.2024.111469_bib48) 2021; 13 Doppenberg (10.1016/j.jclinepi.2024.111469_bib47) 2022; 22 Koutoukidis (10.1016/j.jclinepi.2024.111469_bib44) 2020; 123 Reeves (10.1016/j.jclinepi.2024.111469_bib15) 2018; 95 Cockayne (10.1016/j.jclinepi.2024.111469_bib62) 2021; 25 Verweij (10.1016/j.jclinepi.2024.111469_bib74) 2022; 148 Tricco (10.1016/j.jclinepi.2024.111469_bib17) 2018; 169 Amstutz (10.1016/j.jclinepi.2024.111469_bib19) 2022 Vickers (10.1016/j.jclinepi.2024.111469_bib66) 2023; 20 Jongbloed (10.1016/j.jclinepi.2024.111469_bib58) 2016; 17 Speich (10.1016/j.jclinepi.2024.111469_bib6) 2022; 19 Higgins (10.1016/j.jclinepi.2024.111469_bib76) 2011; 343 Anderson (10.1016/j.jclinepi.2024.111469_bib39) 2018; 19 O'Brien (10.1016/j.jclinepi.2024.111469_bib24) 2018; 18 Schraa (10.1016/j.jclinepi.2024.111469_bib45) 2020; 20 Schwartz (10.1016/j.jclinepi.2024.111469_bib7) 1967; 20 Couwenberg (10.1016/j.jclinepi.2024.111469_bib50) 2020; 108 Viksveen (10.1016/j.jclinepi.2024.111469_bib38) 2017; 18 Konwar (10.1016/j.jclinepi.2024.111469_bib69) 2018; 9 Peckham (10.1016/j.jclinepi.2024.111469_bib61) 2014; 103 Ford (10.1016/j.jclinepi.2024.111469_bib8) 2016; 375 Sagarin (10.1016/j.jclinepi.2024.111469_bib78) 2014; 19 Lousdal (10.1016/j.jclinepi.2024.111469_bib80) 2018; 15 Vickers (10.1016/j.jclinepi.2024.111469_bib11) 2018; 15 Gal (10.1016/j.jclinepi.2024.111469_bib56) 2021; 190 Gal (10.1016/j.jclinepi.2024.111469_bib84) 2019; 113 van der Velden (10.1016/j.jclinepi.2024.111469_bib9) 2017; 46 Kim (10.1016/j.jclinepi.2024.111469_bib13) 2018; 15 Gerber (10.1016/j.jclinepi.2024.111469_bib67) 2023; 24 Fisher (10.1016/j.jclinepi.2024.111469_bib1) 1930 Snider (10.1016/j.jclinepi.2024.111469_bib60) 2020; 22 Mariette (10.1016/j.jclinepi.2024.111469_bib32) 2020; 59 Young-Afat (10.1016/j.jclinepi.2024.111469_bib73) 2021; 130 (10.1016/j.jclinepi.2024.111469_bib33) 2021; 9 Touzet (10.1016/j.jclinepi.2024.111469_bib42) 2017; 7 Relton (10.1016/j.jclinepi.2024.111469_bib10) 2010; 340 Bibby (10.1016/j.jclinepi.2024.111469_bib55) 2022; 8 Nickolls (10.1016/j.jclinepi.2024.111469_bib85) 2024; 14 Stefanick (10.1016/j.jclinepi.2024.111469_bib59) 2021; 76 Rannou (10.1016/j.jclinepi.2024.111469_bib63) 2017; 69 Harris (10.1016/j.jclinepi.2024.111469_bib22) 2009; 42 Caille (10.1016/j.jclinepi.2024.111469_bib64) 2023; 14 Pate (10.1016/j.jclinepi.2024.111469_bib14) 2016; 16 Engelmann (10.1016/j.jclinepi.2024.111469_bib43) 2022; 30 Kwakkenbos (10.1016/j.jclinepi.2024.111469_bib52) 2022; 23 Williams (10.1016/j.jclinepi.2024.111469_bib28) 2018; 159 Fahim (10.1016/j.jclinepi.2024.111469_bib53) 2022; 109 Fibert (10.1016/j.jclinepi.2024.111469_bib54) 2019; 178 Huele (10.1016/j.jclinepi.2024.111469_bib65) 2023; 24 Mink van der Molen (10.1016/j.jclinepi.2024.111469_bib40) 2024; 10 Cockayne (10.1016/j.jclinepi.2024.111469_bib51) 2017; 12 Koutoukidis (10.1016/j.jclinepi.2024.111469_bib70) 2020; 123 Colagiuri (10.1016/j.jclinepi.2024.111469_bib46) 2021; 11 Stuart (10.1016/j.jclinepi.2024.111469_bib79) 2008; 9 Couwenberg (10.1016/j.jclinepi.2024.111469_bib83) 2020; 120 |
References_xml | – volume: 42 start-page: 377 year: 2009 end-page: 381 ident: bib22 article-title: Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support publication-title: J Biomed Inform contributor: fullname: Conde – ident: bib20 article-title: TwiCs Global Network – volume: 9 start-page: 295 year: 2021 end-page: 304 ident: bib33 article-title: Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial publication-title: Lancet Respir Med – volume: 95 year: 2019 ident: bib21 article-title: The REDCap consortium: building an international community of software platform partners publication-title: J Biomed Inform contributor: fullname: O'Neal – volume: 8 start-page: 196 year: 2022 ident: bib55 article-title: A trial of intra-pleural bacterial immunotherapy in malignant pleural mesothelioma (TILT) - a randomised feasibility study using the trial within a cohort (TwiC) methodology publication-title: Pilot Feasibility Stud contributor: fullname: Day – volume: 20 start-page: 226 year: 2020 ident: bib18 article-title: A tutorial on methodological studies: the what, when, how and why publication-title: BMC Med Res Methodol contributor: fullname: Thabane – volume: 15 start-page: 9 year: 2018 end-page: 16 ident: bib13 article-title: Ethics and practice of Trials within Cohorts: an emerging pragmatic trial design publication-title: Clin Trials contributor: fullname: Relton – volume: 159 start-page: 1137 year: 2018 end-page: 1146 ident: bib28 article-title: The effectiveness of a healthy lifestyle intervention, for chronic low back pain: a randomised controlled trial. Journal article publication-title: Pain contributor: fullname: Hodder – volume: 27 start-page: 393 year: 2016 end-page: 394 ident: bib72 article-title: Randomize, then consent or consent, then randomize? revitalizing the issue of preconsent randomization publication-title: Epidemiology contributor: fullname: Bretthauer – volume: 30 year: 2022 ident: bib43 article-title: From the identification of biopsychosocial risk factors to an increase in pain-related self-efficacy (IDRIS) - the online-based conveyance of an explanatory model for chronic back pain: study protocol of a cohort multiple randomized controlled trial publication-title: Internet Interv contributor: fullname: Husing – volume: 175 start-page: 347 year: 2006 ident: bib81 article-title: Is there another way to take account of noncompliance in randomized controlled trials? publication-title: CMAJ (Can Med Assoc J) contributor: fullname: Miles – volume: 10 start-page: 37 year: 2009 ident: bib5 article-title: Making trials matter: pragmatic and explanatory trials and the problem of applicability publication-title: Trials contributor: fullname: Zwarenstein – volume: 7 year: 2017 ident: bib42 article-title: Impact of the Early Start Denver Model on the cognitive level of children with autism spectrum disorder: study protocol for a randomised controlled trial using a two-stage Zelen design publication-title: BMJ Open contributor: fullname: Stanciu – volume: 16 start-page: 109 year: 2016 ident: bib14 article-title: Cohort Multiple Randomised Controlled Trials (cmRCT) design: efficient but biased? A simulation study to evaluate the feasibility of the Cluster cmRCT design publication-title: BMC Med Res Methodol contributor: fullname: Van Staa – volume: 10 start-page: 464 year: 2024 end-page: 474 ident: bib40 article-title: Hyperbaric oxygen therapy and late local toxic effects in patients with irradiated breast cancer: a randomized clinical trial publication-title: JAMA Oncol contributor: fullname: de Lange – volume: 20 start-page: 637 year: 1967 end-page: 648 ident: bib7 article-title: Explanatory and pragmatic attitudes in therapeutical trials publication-title: J Chronic Dis contributor: fullname: Lellouch – volume: 23 start-page: 913 year: 2022 ident: bib31 article-title: A nationwide randomized controlled trial on additional treatment for isolated local pancreatic cancer recurrence using stereotactic body radiation therapy (ARCADE). Randomized Controlled Trial publication-title: Trials [Electronic Resource] contributor: fullname: Cirkel – volume: 378 year: 2022 ident: bib37 article-title: Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT) publication-title: BMJ contributor: fullname: Pfeffer – volume: 14 year: 2023 ident: bib64 article-title: EMDR for symptoms of depression, stress and burnout in health care workers exposed to COVID-19 (HARD): a study protocol for a trial within a cohort study publication-title: Eur J Psychotraumatol contributor: fullname: Gohier – volume: 46 year: 2022 ident: bib36 article-title: Tocilizumab plus dexamethasone versus dexamethasone in patients with moderate-to-severe COVID-19 pneumonia: a randomised clinical trial from the CORIMUNO-19 study group publication-title: EClinicalMedicine contributor: fullname: Arlet – volume: 343 year: 2011 ident: bib76 article-title: The Cochrane Collaboration's tool for assessing risk of bias in randomised trials publication-title: BMJ contributor: fullname: Oxman – volume: 375 start-page: 454 year: 2016 end-page: 463 ident: bib8 article-title: Pragmatic trials publication-title: N Engl J Med contributor: fullname: Norrie – volume: 108 start-page: 1008 year: 2020 end-page: 1018 ident: bib50 article-title: Efficacy of dose-escalated chemoradiation on Complete tumor response in patients with locally advanced rectal cancer (RECTAL-BOOST): a phase 2 randomized controlled trial publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Raicu – volume: 103 start-page: 172 year: 2014 end-page: 177 ident: bib61 article-title: Interim results of a randomised controlled trial of homeopathic treatment for irritable bowel syndrome publication-title: Homeopathy contributor: fullname: Smith – volume: 340 year: 2010 ident: bib10 article-title: Rethinking pragmatic randomised controlled trials: introducing the "cohort multiple randomised controlled trial" design publication-title: BMJ contributor: fullname: Nicholl – volume: 25 start-page: 1 year: 2021 end-page: 118 ident: bib62 article-title: Home environmental assessments and modification delivered by occupational therapists to reduce falls in people aged 65 years and over: the OTIS RCT publication-title: Health Technol Assess contributor: fullname: Drummond – year: 2022 ident: bib77 article-title: COVID-19 convalescent plasma to treat hospitalised COVID-19 patients with or without underlying immunodeficiency publication-title: medRxiv contributor: fullname: Georgin-Lavialle – year: 2022 ident: bib30 article-title: Isrctn. Feasibility, effectiveness and experiences of creativity workshops for young adults with anxiety and depression. Trial registry record; Clinical trial protocol – volume: 4 start-page: e24 year: 2022 end-page: e32 ident: bib34 article-title: Sarilumab in adults hospitalised with moderate-to-severe COVID-19 pneumonia (CORIMUNO-SARI-1): an open-label randomised controlled trial publication-title: Lancet Rheumatol – volume: 22 start-page: 313 year: 2020 end-page: 320 ident: bib60 article-title: Feasibility and efficacy of a hospital-based violence intervention program on reducing repeat violent injury in youth: a randomized control trial publication-title: CJEM contributor: fullname: Cochrane – ident: bib23 article-title: R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria – volume: 33 start-page: 853 year: 2012 end-page: 859 ident: bib41 article-title: A pilot 'cohort multiple randomised controlled trial' of treatment by a homeopath for women with menopausal hot flushes publication-title: Contemp Clin Trials contributor: fullname: Nicholl – volume: 17 start-page: 128 year: 2016 ident: bib58 article-title: The Cedar Project WelTel mHealth intervention for HIV prevention in young Indigenous people who use illicit drugs: study protocol for a randomized controlled trial publication-title: Trials [Electronic Resource] contributor: fullname: Demerais – volume: 16 start-page: 80 year: 2018 ident: bib49 article-title: Is telephone health coaching a useful population health strategy for supporting older people with multimorbidity? An evaluation of reach, effectiveness and cost-effectiveness using a 'trial within a cohort'. Research Support, Non-U.S. Gov't publication-title: BMC Med contributor: fullname: Hann – year: 2022 ident: bib27 article-title: Emptying malaria reservoirs to accelerate malaria elimination in high transmission settings. Trial registry record; Clinical trial protocol – volume: 9 start-page: 288 year: 2008 end-page: 298 ident: bib79 article-title: Estimating intervention effects of prevention programs: accounting for noncompliance publication-title: Prev Sci contributor: fullname: Ialongo – volume: 22 start-page: 1363 year: 2022 ident: bib47 article-title: Stereotactic ablative radiotherapy or best supportive care in patients with localized pancreatic cancer not receiving chemotherapy and surgery (PANCOSAR): a nationwide multicenter randomized controlled trial according to a TwiCs design publication-title: BMC Cancer contributor: fullname: Kazemier – year: 2022 ident: bib29 article-title: Isrctn. Feasibility, effectiveness, and experiences of music workshops for adolescents with anxiety and depression. Trial registry record; Clinical trial protocol – volume: 148 start-page: 160 year: 2022 end-page: 169 ident: bib82 article-title: Most healthcare interventions tested in Cochrane Reviews are not effective according to high quality evidence: a systematic review and meta-analysis publication-title: J Clin Epidemiol contributor: fullname: Loef – year: 1930 ident: bib1 article-title: The arrangement of field experiments and the statistical reduction of the results publication-title: Imperial Bureau of Soil Science contributor: fullname: Wishart – volume: 19 year: 2022 ident: bib6 article-title: Nonregistration, discontinuation, and nonpublication of randomized trials: a repeated metaresearch analysis publication-title: PLoS Med contributor: fullname: Klatte – volume: 59 start-page: 988 year: 2020 end-page: 996 ident: bib32 article-title: Role of good oral hygiene on clinical evolution of rheumatoid arthritis: a randomized study nested in the ESPOIR cohort publication-title: Rheumatology contributor: fullname: Schaeverbeke – volume: 148 start-page: 39 year: 2022 end-page: 47 ident: bib74 article-title: Most patients reported positively or neutrally of having served as controls in the trials within cohorts design. Article publication-title: J Clin Epidemiol contributor: fullname: van der Graaf – volume: 19 start-page: 317 year: 2014 end-page: 333 ident: bib78 article-title: Treatment noncompliance in randomized experiments: statistical approaches and design issues publication-title: Psychol Methods contributor: fullname: Hansen – volume: 113 start-page: 137 year: 2019 end-page: 146 ident: bib84 article-title: The Trials within Cohorts design faced methodological advantages and disadvantages in the exercise oncology setting publication-title: J Clin Epidemiol contributor: fullname: Peeters – volume: 14 year: 2024 ident: bib85 article-title: Randomised trials conducted using cohorts: a scoping review publication-title: BMJ Open contributor: fullname: McCall – volume: 9 start-page: 179 year: 2018 end-page: 183 ident: bib69 article-title: Investigator-initiated studies: challenges and solutions publication-title: Perspect Clin Res contributor: fullname: Thatte – volume: 60 start-page: 7 year: 2017 end-page: 24 ident: bib16 article-title: Beyond intent to treat (ITT): a complier average causal effect (CACE) estimation primer publication-title: J Sch Psychol contributor: fullname: Kashikar-Zuck – volume: 95 start-page: 111 year: Mar 2018 end-page: 119 ident: bib15 article-title: The cohort multiple randomized controlled trial design was found to be highly susceptible to low statistical power and internal validity biases publication-title: J Clin Epidemiol contributor: fullname: Panagioti – volume: 24 start-page: 307 year: 2023 ident: bib65 article-title: Stereotactic Body radiotherapy and pedicLE screw fixatioN during one hospital visit for patients with symptomatic unstable spinal metastases: a randomized trial (BLEND RCT) using the Trials within Cohorts (TwiCs) design publication-title: Trials contributor: fullname: Suelmann – volume: 76 start-page: 725 year: 2021 end-page: 734 ident: bib59 article-title: Women's health initiative strong and healthy pragmatic physical activity intervention trial for cardiovascular disease prevention: design and baseline characteristics. Journal article; clinical trial protocol publication-title: J Gerontol A Biol Sci Med Sci contributor: fullname: LaMonte – volume: 123 start-page: 187 year: 2020 end-page: 195 ident: bib70 article-title: Fatigue, quality of life and physical fitness following an exercise intervention in multiple myeloma survivors (MASCOT): an exploratory randomised Phase 2 trial utilising a modified Zelen design publication-title: Br J Cancer contributor: fullname: Beeken – volume: 15 start-page: 1 year: 2018 ident: bib80 article-title: An introduction to instrumental variable assumptions, validation and estimation publication-title: Emerg Themes Epidemiol contributor: fullname: Lousdal – volume: 46 start-page: 96 year: 2017 end-page: 102 ident: bib9 article-title: The cohort multiple randomized controlled trial design: a valid and efficient alternative to pragmatic trials? publication-title: Int J Epidemiol contributor: fullname: Relton – volume: 19 start-page: 457 year: 2018 ident: bib39 article-title: Frailty Intervention Trial iN End-Stage patientS on haemodialysis (FITNESS): study protocol for a randomised controlled trial. Clinical Trial Protocol publication-title: Trials [Electronic Resource] contributor: fullname: Sharif – volume: 27 start-page: 389 year: 2016 end-page: 392 ident: bib12 article-title: Brief report: staged-informed consent in the cohort multiple randomized controlled trial design publication-title: Epidemiology contributor: fullname: Elias – volume: 110 start-page: 358 year: 2021 end-page: 367 ident: bib57 article-title: Pain response after stereotactic body radiation therapy versus conventional radiation therapy in patients with bone metastases—a phase 2 randomized controlled trial within a prospective cohort. Article publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Verhoeff – year: 2022 ident: bib19 article-title: Study Protocol for a Review of Randomized Clinical Trials Using the Trials within Cohorts (TwiCs) Approach: A Meta-Research Project contributor: fullname: James – volume: 25 start-page: 365 year: 2024 ident: bib68 article-title: Community-based management of arterial hypertension and cardiovascular risk factors by lay village health workers for people with controlled and uncontrolled blood pressure in rural Lesotho: joint protocol for two cluster-randomized trials within the ComBaCaL cohort study (ComBaCaL aHT Twic 1 and ComBaCaL aHT TwiC 2) publication-title: Trials contributor: fullname: Sanchez-Samaniego – volume: 85 start-page: 333 year: 2024 end-page: 336 ident: bib26 article-title: Nephron sparing treatment (NEST) for small renal masses: a feasibility cohort-embedded randomised controlled trial comparing percutaneous cryoablation and robot-assisted partial nephrectomy publication-title: Eur Urol contributor: fullname: Pavlou – volume: 7 start-page: 9 year: 2006 ident: bib4 article-title: What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies publication-title: Trials contributor: fullname: Cook – volume: 300 start-page: 1242 year: 1979 end-page: 1245 ident: bib71 article-title: A new design for randomized clinical trials publication-title: N Engl J Med contributor: fullname: Zelen – volume: 13 start-page: 217 year: 2011 end-page: 224 ident: bib75 article-title: A pragmatic view on pragmatic trials publication-title: Dialogues Clin Neurosci contributor: fullname: Patsopoulos – volume: 123 start-page: 187 year: 2020 end-page: 195 ident: bib44 article-title: Fatigue, quality of life and physical fitness following an exercise intervention in multiple myeloma survivors (MASCOT): an exploratory randomised Phase 2 trial utilising a modified Zelen design. Journal Article; Clinical Trial Protocol publication-title: Br J Cancer contributor: fullname: Beeken – volume: 21 start-page: 125 year: 2016 end-page: 127 ident: bib2 article-title: New evidence pyramid publication-title: Evid Based Med contributor: fullname: Alahdab – volume: 178 start-page: 983 year: 2019 end-page: 993 ident: bib54 article-title: Rethinking ADHD intervention trials: feasibility testing of two treatments and a methodology. Article publication-title: Eur J Pediatr contributor: fullname: Relton – volume: 363 start-page: 306 year: 2010 end-page: 309 ident: bib3 article-title: Cancer clinical trials--a chronic but curable crisis publication-title: N Engl J Med contributor: fullname: Young – volume: 130 start-page: 135 year: 2021 end-page: 142 ident: bib73 article-title: Oncology patients were found to understand and accept the Trials within Cohorts design. Review publication-title: J Clin Epidemiol contributor: fullname: van den Bongard – volume: 24 start-page: 688 year: 2023 ident: bib67 article-title: Community-based type 2 diabetes care by lay village health workers in rural Lesotho: protocol for a cluster-randomized trial within the ComBaCaL cohort study (ComBaCaL T2D TwiC) publication-title: Trials contributor: fullname: Kohler – volume: 20 year: 2020 ident: bib45 article-title: Circulating tumor DNA guided adjuvant chemotherapy in stage II colon cancer (MEDOCC-CrEATE): study protocol for a trial within a cohort study. Journal Article; Clinical Trial Protocol publication-title: BMC Cancer contributor: fullname: Sausen – volume: 120 start-page: 33 year: 2020 end-page: 39 ident: bib83 article-title: The trials within cohorts design facilitated efficient patient enrollment and generalizability in oncology setting publication-title: J Clin Epidemiol contributor: fullname: Verkooijen – volume: 13 year: 2021 ident: bib48 article-title: Clinical effectiveness of symptomatic therapy compared with standard step-up care for the treatment of low-impact psoriatic oligoarthritis: the two-arm parallel group randomised POISE feasibility study publication-title: Ther Adv Musculoskelet Dis contributor: fullname: Francis – volume: 190 start-page: 89 year: 2021 end-page: 101 ident: bib56 article-title: Effects of exercise in breast cancer patients: implications of the trials within cohorts (TwiCs) design in the UMBRELLA Fit trial publication-title: Breast Cancer Res Treat contributor: fullname: van den Bongard – volume: 15 start-page: 3 year: 2018 end-page: 8 ident: bib11 article-title: Just-in-time consent: the ethical case for an alternative to traditional informed consent in randomized trials comparing an experimental intervention with usual care publication-title: Clin Trials contributor: fullname: Kim – volume: 181 start-page: 32 year: 2021 end-page: 40 ident: bib35 article-title: Effect of tocilizumab vs usual care in adults hospitalized with COVID-19 and moderate or severe pneumonia: a randomized clinical trial publication-title: JAMA Intern Med contributor: fullname: Ravaud – volume: 18 start-page: 299 year: 2017 ident: bib38 article-title: Depressed patients treated by homeopaths: a randomised controlled trial using the "cohort multiple randomised controlled trial" (cmRCT) design. Article publication-title: Trials contributor: fullname: Nicholl – volume: 18 start-page: 1408 year: 2018 ident: bib24 article-title: Economic evaluation of telephone-based weight loss support for patients with knee osteoarthritis: a randomised controlled trial. Article publication-title: BMC Public Health contributor: fullname: Hodder – volume: 23 start-page: 994 year: 2022 ident: bib52 article-title: Randomized controlled trial of an internet-based self-guided hand exercise program to improve hand function in people with systemic sclerosis: the Scleroderma Patient-centered Intervention Network Hand Exercise Program (SPIN-HAND) trial. Randomized Controlled Trial publication-title: Trials [Electronic Resource] contributor: fullname: Sauve – volume: 11 year: 2021 ident: bib46 article-title: Open-label placebo for insomnia (OPIN): study protocol for a cohort multiple randomised controlled trial publication-title: BMJ Open contributor: fullname: Costa – volume: 109 start-page: 1081 year: 2022 end-page: 1086 ident: bib53 article-title: SPONGE-assisted versus Trendelenburg position surgery in laparoscopic sigmoid and rectal cancer surgery (SPONGE trial): randomized clinical trial publication-title: Bri J Surg contributor: fullname: Smits – volume: 2 year: 2023 ident: bib25 article-title: Use of covid-19 convalescent plasma to treat patients admitted to hospital for covid-19 with or without underlying immunodeficiency: open label, randomised clinical trial publication-title: BMJ Med contributor: fullname: Georgin-Lavialle – volume: 69 start-page: 1050 year: 2017 end-page: 1059 ident: bib63 article-title: Personalized physical therapy versus usual care for patients with systemic sclerosis: a randomized controlled trial. Article publication-title: Arthritis Care Res contributor: fullname: Hachulla – volume: 12 year: 2017 ident: bib51 article-title: Cohort randomised controlled trial of a multifaceted podiatry intervention for the prevention of falls in older people (the REFORM trial) publication-title: PLoS One contributor: fullname: Green – volume: 20 start-page: 642 year: 2023 end-page: 648 ident: bib66 article-title: A randomized comparison of two-stage versus traditional one-stage consent for a low-stakes randomized trial publication-title: Clin Trials contributor: fullname: Kim – volume: 169 start-page: 467 year: 2018 end-page: 473 ident: bib17 article-title: PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation publication-title: Ann Intern Med contributor: fullname: Levac – volume: 15 start-page: 9 year: 2018 ident: 10.1016/j.jclinepi.2024.111469_bib13 article-title: Ethics and practice of Trials within Cohorts: an emerging pragmatic trial design publication-title: Clin Trials doi: 10.1177/1740774517746620 contributor: fullname: Kim – volume: 46 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib36 article-title: Tocilizumab plus dexamethasone versus dexamethasone in patients with moderate-to-severe COVID-19 pneumonia: a randomised clinical trial from the CORIMUNO-19 study group publication-title: EClinicalMedicine doi: 10.1016/j.eclinm.2022.101362 contributor: fullname: Hermine – volume: 7 start-page: 9 year: 2006 ident: 10.1016/j.jclinepi.2024.111469_bib4 article-title: What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies publication-title: Trials doi: 10.1186/1745-6215-7-9 contributor: fullname: McDonald – volume: 103 start-page: 172 issue: 3 year: 2014 ident: 10.1016/j.jclinepi.2024.111469_bib61 article-title: Interim results of a randomised controlled trial of homeopathic treatment for irritable bowel syndrome publication-title: Homeopathy doi: 10.1016/j.homp.2014.05.001 contributor: fullname: Peckham – volume: 23 start-page: 913 issue: 1 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib31 article-title: A nationwide randomized controlled trial on additional treatment for isolated local pancreatic cancer recurrence using stereotactic body radiation therapy (ARCADE). Randomized Controlled Trial publication-title: Trials [Electronic Resource] contributor: fullname: van Goor – volume: 15 start-page: 3 year: 2018 ident: 10.1016/j.jclinepi.2024.111469_bib11 article-title: Just-in-time consent: the ethical case for an alternative to traditional informed consent in randomized trials comparing an experimental intervention with usual care publication-title: Clin Trials doi: 10.1177/1740774517746610 contributor: fullname: Vickers – volume: 108 start-page: 1008 issue: 4 year: 2020 ident: 10.1016/j.jclinepi.2024.111469_bib50 article-title: Efficacy of dose-escalated chemoradiation on Complete tumor response in patients with locally advanced rectal cancer (RECTAL-BOOST): a phase 2 randomized controlled trial publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2020.06.013 contributor: fullname: Couwenberg – volume: 15 start-page: 1 year: 2018 ident: 10.1016/j.jclinepi.2024.111469_bib80 article-title: An introduction to instrumental variable assumptions, validation and estimation publication-title: Emerg Themes Epidemiol doi: 10.1186/s12982-018-0069-7 contributor: fullname: Lousdal – volume: 148 start-page: 39 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib74 article-title: Most patients reported positively or neutrally of having served as controls in the trials within cohorts design. Article publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2022.04.015 contributor: fullname: Verweij – year: 1930 ident: 10.1016/j.jclinepi.2024.111469_bib1 article-title: The arrangement of field experiments and the statistical reduction of the results contributor: fullname: Fisher – volume: 340 year: 2010 ident: 10.1016/j.jclinepi.2024.111469_bib10 article-title: Rethinking pragmatic randomised controlled trials: introducing the "cohort multiple randomised controlled trial" design publication-title: BMJ doi: 10.1136/bmj.c1066 contributor: fullname: Relton – year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib19 contributor: fullname: Amstutz – volume: 20 start-page: 637 issue: 8 year: 1967 ident: 10.1016/j.jclinepi.2024.111469_bib7 article-title: Explanatory and pragmatic attitudes in therapeutical trials publication-title: J Chronic Dis doi: 10.1016/0021-9681(67)90041-0 contributor: fullname: Schwartz – volume: 19 issue: 4 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib6 article-title: Nonregistration, discontinuation, and nonpublication of randomized trials: a repeated metaresearch analysis publication-title: PLoS Med doi: 10.1371/journal.pmed.1003980 contributor: fullname: Speich – volume: 181 start-page: 32 issue: 1 year: 2021 ident: 10.1016/j.jclinepi.2024.111469_bib35 article-title: Effect of tocilizumab vs usual care in adults hospitalized with COVID-19 and moderate or severe pneumonia: a randomized clinical trial publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2020.6820 contributor: fullname: Hermine – year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib77 article-title: COVID-19 convalescent plasma to treat hospitalised COVID-19 patients with or without underlying immunodeficiency publication-title: medRxiv contributor: fullname: Lacombe – volume: 2 issue: 1 year: 2023 ident: 10.1016/j.jclinepi.2024.111469_bib25 article-title: Use of covid-19 convalescent plasma to treat patients admitted to hospital for covid-19 with or without underlying immunodeficiency: open label, randomised clinical trial publication-title: BMJ Med doi: 10.1136/bmjmed-2022-000427 contributor: fullname: Lacombe – volume: 20 start-page: 226 year: 2020 ident: 10.1016/j.jclinepi.2024.111469_bib18 article-title: A tutorial on methodological studies: the what, when, how and why publication-title: BMC Med Res Methodol doi: 10.1186/s12874-020-01107-7 contributor: fullname: Mbuagbaw – volume: 95 year: 2019 ident: 10.1016/j.jclinepi.2024.111469_bib21 article-title: The REDCap consortium: building an international community of software platform partners publication-title: J Biomed Inform doi: 10.1016/j.jbi.2019.103208 contributor: fullname: Harris – volume: 10 start-page: 37 year: 2009 ident: 10.1016/j.jclinepi.2024.111469_bib5 article-title: Making trials matter: pragmatic and explanatory trials and the problem of applicability publication-title: Trials doi: 10.1186/1745-6215-10-37 contributor: fullname: Treweek – volume: 23 start-page: 994 issue: 1 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib52 publication-title: Trials [Electronic Resource] contributor: fullname: Kwakkenbos – volume: 169 start-page: 467 year: 2018 ident: 10.1016/j.jclinepi.2024.111469_bib17 article-title: PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation publication-title: Ann Intern Med doi: 10.7326/M18-0850 contributor: fullname: Tricco – volume: 113 start-page: 137 year: 2019 ident: 10.1016/j.jclinepi.2024.111469_bib84 article-title: The Trials within Cohorts design faced methodological advantages and disadvantages in the exercise oncology setting publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2019.05.017 contributor: fullname: Gal – volume: 19 start-page: 317 issue: 3 year: 2014 ident: 10.1016/j.jclinepi.2024.111469_bib78 article-title: Treatment noncompliance in randomized experiments: statistical approaches and design issues publication-title: Psychol Methods doi: 10.1037/met0000013 contributor: fullname: Sagarin – volume: 17 start-page: 128 issue: 1 year: 2016 ident: 10.1016/j.jclinepi.2024.111469_bib58 article-title: The Cedar Project WelTel mHealth intervention for HIV prevention in young Indigenous people who use illicit drugs: study protocol for a randomized controlled trial publication-title: Trials [Electronic Resource] contributor: fullname: Jongbloed – volume: 16 start-page: 109 year: 2016 ident: 10.1016/j.jclinepi.2024.111469_bib14 article-title: Cohort Multiple Randomised Controlled Trials (cmRCT) design: efficient but biased? A simulation study to evaluate the feasibility of the Cluster cmRCT design publication-title: BMC Med Res Methodol doi: 10.1186/s12874-016-0208-1 contributor: fullname: Pate – volume: 46 start-page: 96 year: 2017 ident: 10.1016/j.jclinepi.2024.111469_bib9 article-title: The cohort multiple randomized controlled trial design: a valid and efficient alternative to pragmatic trials? publication-title: Int J Epidemiol contributor: fullname: van der Velden – volume: 110 start-page: 358 issue: 2 year: 2021 ident: 10.1016/j.jclinepi.2024.111469_bib57 article-title: Pain response after stereotactic body radiation therapy versus conventional radiation therapy in patients with bone metastases—a phase 2 randomized controlled trial within a prospective cohort. Article publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2020.11.060 contributor: fullname: Pielkenrood – volume: 20 issue: 1 year: 2020 ident: 10.1016/j.jclinepi.2024.111469_bib45 article-title: Circulating tumor DNA guided adjuvant chemotherapy in stage II colon cancer (MEDOCC-CrEATE): study protocol for a trial within a cohort study. Journal Article; Clinical Trial Protocol publication-title: BMC Cancer doi: 10.1186/s12885-020-07252-y contributor: fullname: Schraa – volume: 190 start-page: 89 issue: 1 year: 2021 ident: 10.1016/j.jclinepi.2024.111469_bib56 article-title: Effects of exercise in breast cancer patients: implications of the trials within cohorts (TwiCs) design in the UMBRELLA Fit trial publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-021-06363-9 contributor: fullname: Gal – volume: 9 start-page: 288 issue: 4 year: 2008 ident: 10.1016/j.jclinepi.2024.111469_bib79 article-title: Estimating intervention effects of prevention programs: accounting for noncompliance publication-title: Prev Sci doi: 10.1007/s11121-008-0104-y contributor: fullname: Stuart – volume: 18 start-page: 1408 year: 2018 ident: 10.1016/j.jclinepi.2024.111469_bib24 article-title: Economic evaluation of telephone-based weight loss support for patients with knee osteoarthritis: a randomised controlled trial. Article publication-title: BMC Public Health doi: 10.1186/s12889-018-6300-1 contributor: fullname: O'Brien – volume: 16 start-page: 80 issue: 1 year: 2018 ident: 10.1016/j.jclinepi.2024.111469_bib49 article-title: Is telephone health coaching a useful population health strategy for supporting older people with multimorbidity? An evaluation of reach, effectiveness and cost-effectiveness using a 'trial within a cohort'. Research Support, Non-U.S. Gov't publication-title: BMC Med doi: 10.1186/s12916-018-1051-5 contributor: fullname: Panagioti – volume: 148 start-page: 160 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib82 article-title: Most healthcare interventions tested in Cochrane Reviews are not effective according to high quality evidence: a systematic review and meta-analysis publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2022.04.017 contributor: fullname: Howick – volume: 11 issue: 2 year: 2021 ident: 10.1016/j.jclinepi.2024.111469_bib46 article-title: Open-label placebo for insomnia (OPIN): study protocol for a cohort multiple randomised controlled trial publication-title: BMJ Open doi: 10.1136/bmjopen-2020-044045 contributor: fullname: Colagiuri – volume: 13 year: 2021 ident: 10.1016/j.jclinepi.2024.111469_bib48 article-title: Clinical effectiveness of symptomatic therapy compared with standard step-up care for the treatment of low-impact psoriatic oligoarthritis: the two-arm parallel group randomised POISE feasibility study publication-title: Ther Adv Musculoskelet Dis contributor: fullname: Rombach – volume: 95 start-page: 111 year: 2018 ident: 10.1016/j.jclinepi.2024.111469_bib15 article-title: The cohort multiple randomized controlled trial design was found to be highly susceptible to low statistical power and internal validity biases publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2017.12.008 contributor: fullname: Reeves – volume: 10 start-page: 464 issue: 4 year: 2024 ident: 10.1016/j.jclinepi.2024.111469_bib40 article-title: Hyperbaric oxygen therapy and late local toxic effects in patients with irradiated breast cancer: a randomized clinical trial publication-title: JAMA Oncol doi: 10.1001/jamaoncol.2023.6776 contributor: fullname: Mink van der Molen – volume: 25 start-page: 365 issue: 1 year: 2024 ident: 10.1016/j.jclinepi.2024.111469_bib68 publication-title: Trials doi: 10.1186/s13063-024-08226-2 contributor: fullname: Gerber – volume: 4 start-page: e24 issue: 1 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib34 article-title: Sarilumab in adults hospitalised with moderate-to-severe COVID-19 pneumonia (CORIMUNO-SARI-1): an open-label randomised controlled trial publication-title: Lancet Rheumatol doi: 10.1016/S2665-9913(21)00315-5 – volume: 130 start-page: 135 year: 2021 ident: 10.1016/j.jclinepi.2024.111469_bib73 article-title: Oncology patients were found to understand and accept the Trials within Cohorts design. Review publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2020.10.015 contributor: fullname: Young-Afat – volume: 85 start-page: 333 issue: 4 year: 2024 ident: 10.1016/j.jclinepi.2024.111469_bib26 article-title: Nephron sparing treatment (NEST) for small renal masses: a feasibility cohort-embedded randomised controlled trial comparing percutaneous cryoablation and robot-assisted partial nephrectomy publication-title: Eur Urol doi: 10.1016/j.eururo.2023.07.012 contributor: fullname: Neves – volume: 363 start-page: 306 year: 2010 ident: 10.1016/j.jclinepi.2024.111469_bib3 article-title: Cancer clinical trials--a chronic but curable crisis publication-title: N Engl J Med doi: 10.1056/NEJMp1005843 contributor: fullname: Young – volume: 178 start-page: 983 issue: 7 year: 2019 ident: 10.1016/j.jclinepi.2024.111469_bib54 article-title: Rethinking ADHD intervention trials: feasibility testing of two treatments and a methodology. Article publication-title: Eur J Pediatr doi: 10.1007/s00431-019-03374-z contributor: fullname: Fibert – volume: 27 start-page: 393 year: 2016 ident: 10.1016/j.jclinepi.2024.111469_bib72 article-title: Randomize, then consent or consent, then randomize? revitalizing the issue of preconsent randomization publication-title: Epidemiology doi: 10.1097/EDE.0000000000000469 contributor: fullname: Loberg – volume: 25 start-page: 1 year: 2021 ident: 10.1016/j.jclinepi.2024.111469_bib62 article-title: Home environmental assessments and modification delivered by occupational therapists to reduce falls in people aged 65 years and over: the OTIS RCT publication-title: Health Technol Assess doi: 10.3310/hta25460 contributor: fullname: Cockayne – volume: 60 start-page: 7 year: 2017 ident: 10.1016/j.jclinepi.2024.111469_bib16 article-title: Beyond intent to treat (ITT): a complier average causal effect (CACE) estimation primer publication-title: J Sch Psychol doi: 10.1016/j.jsp.2015.12.006 contributor: fullname: Peugh – volume: 69 start-page: 1050 issue: 7 year: 2017 ident: 10.1016/j.jclinepi.2024.111469_bib63 article-title: Personalized physical therapy versus usual care for patients with systemic sclerosis: a randomized controlled trial. Article publication-title: Arthritis Care Res doi: 10.1002/acr.23098 contributor: fullname: Rannou – volume: 22 start-page: 1363 issue: 1 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib47 article-title: Stereotactic ablative radiotherapy or best supportive care in patients with localized pancreatic cancer not receiving chemotherapy and surgery (PANCOSAR): a nationwide multicenter randomized controlled trial according to a TwiCs design publication-title: BMC Cancer doi: 10.1186/s12885-022-10419-4 contributor: fullname: Doppenberg – volume: 24 start-page: 688 issue: 1 year: 2023 ident: 10.1016/j.jclinepi.2024.111469_bib67 article-title: Community-based type 2 diabetes care by lay village health workers in rural Lesotho: protocol for a cluster-randomized trial within the ComBaCaL cohort study (ComBaCaL T2D TwiC) publication-title: Trials doi: 10.1186/s13063-023-07729-8 contributor: fullname: Gerber – volume: 20 start-page: 642 year: 2023 ident: 10.1016/j.jclinepi.2024.111469_bib66 article-title: A randomized comparison of two-stage versus traditional one-stage consent for a low-stakes randomized trial publication-title: Clin Trials doi: 10.1177/17407745231185058 contributor: fullname: Vickers – volume: 14 issue: 3 year: 2024 ident: 10.1016/j.jclinepi.2024.111469_bib85 article-title: Randomised trials conducted using cohorts: a scoping review publication-title: BMJ Open doi: 10.1136/bmjopen-2023-075601 contributor: fullname: Nickolls – volume: 9 start-page: 295 issue: 3 year: 2021 ident: 10.1016/j.jclinepi.2024.111469_bib33 article-title: Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial publication-title: Lancet Respir Med doi: 10.1016/S2213-2600(20)30556-7 – volume: 123 start-page: 187 year: 2020 ident: 10.1016/j.jclinepi.2024.111469_bib44 article-title: Fatigue, quality of life and physical fitness following an exercise intervention in multiple myeloma survivors (MASCOT): an exploratory randomised Phase 2 trial utilising a modified Zelen design. Journal Article; Clinical Trial Protocol publication-title: Br J Cancer doi: 10.1038/s41416-020-0866-y contributor: fullname: Koutoukidis – volume: 120 start-page: 33 year: 2020 ident: 10.1016/j.jclinepi.2024.111469_bib83 article-title: The trials within cohorts design facilitated efficient patient enrollment and generalizability in oncology setting publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2019.12.015 contributor: fullname: Couwenberg – volume: 375 start-page: 454 year: 2016 ident: 10.1016/j.jclinepi.2024.111469_bib8 article-title: Pragmatic trials publication-title: N Engl J Med doi: 10.1056/NEJMra1510059 contributor: fullname: Ford – volume: 27 start-page: 389 year: 2016 ident: 10.1016/j.jclinepi.2024.111469_bib12 article-title: Brief report: staged-informed consent in the cohort multiple randomized controlled trial design publication-title: Epidemiology doi: 10.1097/EDE.0000000000000435 contributor: fullname: Young-Afat – volume: 19 start-page: 457 issue: 1 year: 2018 ident: 10.1016/j.jclinepi.2024.111469_bib39 article-title: Frailty Intervention Trial iN End-Stage patientS on haemodialysis (FITNESS): study protocol for a randomised controlled trial. Clinical Trial Protocol publication-title: Trials [Electronic Resource] contributor: fullname: Anderson – volume: 21 start-page: 125 issue: 4 year: 2016 ident: 10.1016/j.jclinepi.2024.111469_bib2 article-title: New evidence pyramid publication-title: Evid Based Med doi: 10.1136/ebmed-2016-110401 contributor: fullname: Murad – volume: 12 year: 2017 ident: 10.1016/j.jclinepi.2024.111469_bib51 article-title: Cohort randomised controlled trial of a multifaceted podiatry intervention for the prevention of falls in older people (the REFORM trial) publication-title: PLoS One doi: 10.1371/journal.pone.0168712 contributor: fullname: Cockayne – volume: 14 issue: 1 year: 2023 ident: 10.1016/j.jclinepi.2024.111469_bib64 article-title: EMDR for symptoms of depression, stress and burnout in health care workers exposed to COVID-19 (HARD): a study protocol for a trial within a cohort study publication-title: Eur J Psychotraumatol doi: 10.1080/20008066.2023.2179569 contributor: fullname: Caille – volume: 9 start-page: 179 issue: 4 year: 2018 ident: 10.1016/j.jclinepi.2024.111469_bib69 article-title: Investigator-initiated studies: challenges and solutions publication-title: Perspect Clin Res doi: 10.4103/picr.PICR_106_18 contributor: fullname: Konwar – volume: 33 start-page: 853 issue: 5 year: 2012 ident: 10.1016/j.jclinepi.2024.111469_bib41 article-title: A pilot 'cohort multiple randomised controlled trial' of treatment by a homeopath for women with menopausal hot flushes publication-title: Contemp Clin Trials doi: 10.1016/j.cct.2012.04.003 contributor: fullname: Relton – volume: 343 year: 2011 ident: 10.1016/j.jclinepi.2024.111469_bib76 article-title: The Cochrane Collaboration's tool for assessing risk of bias in randomised trials publication-title: BMJ doi: 10.1136/bmj.d5928 contributor: fullname: Higgins – volume: 30 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib43 article-title: From the identification of biopsychosocial risk factors to an increase in pain-related self-efficacy (IDRIS) - the online-based conveyance of an explanatory model for chronic back pain: study protocol of a cohort multiple randomized controlled trial publication-title: Internet Interv doi: 10.1016/j.invent.2022.100582 contributor: fullname: Engelmann – volume: 8 start-page: 196 issue: 1 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib55 article-title: A trial of intra-pleural bacterial immunotherapy in malignant pleural mesothelioma (TILT) - a randomised feasibility study using the trial within a cohort (TwiC) methodology publication-title: Pilot Feasibility Stud doi: 10.1186/s40814-022-01156-3 contributor: fullname: Bibby – volume: 175 start-page: 347 issue: 4 year: 2006 ident: 10.1016/j.jclinepi.2024.111469_bib81 article-title: Is there another way to take account of noncompliance in randomized controlled trials? publication-title: CMAJ (Can Med Assoc J) doi: 10.1503/cmaj.051625 contributor: fullname: Hewitt – volume: 378 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib37 article-title: Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT) publication-title: BMJ contributor: fullname: Jolliffe – volume: 13 start-page: 217 issue: 2 year: 2011 ident: 10.1016/j.jclinepi.2024.111469_bib75 article-title: A pragmatic view on pragmatic trials publication-title: Dialogues Clin Neurosci doi: 10.31887/DCNS.2011.13.2/npatsopoulos contributor: fullname: Patsopoulos – volume: 7 issue: 3 year: 2017 ident: 10.1016/j.jclinepi.2024.111469_bib42 article-title: Impact of the Early Start Denver Model on the cognitive level of children with autism spectrum disorder: study protocol for a randomised controlled trial using a two-stage Zelen design publication-title: BMJ Open doi: 10.1136/bmjopen-2016-014730 contributor: fullname: Touzet – volume: 300 start-page: 1242 year: 1979 ident: 10.1016/j.jclinepi.2024.111469_bib71 article-title: A new design for randomized clinical trials publication-title: N Engl J Med doi: 10.1056/NEJM197905313002203 contributor: fullname: Zelen – volume: 24 start-page: 307 issue: 1 year: 2023 ident: 10.1016/j.jclinepi.2024.111469_bib65 article-title: Stereotactic Body radiotherapy and pedicLE screw fixatioN during one hospital visit for patients with symptomatic unstable spinal metastases: a randomized trial (BLEND RCT) using the Trials within Cohorts (TwiCs) design publication-title: Trials doi: 10.1186/s13063-023-07315-y contributor: fullname: Huele – volume: 123 start-page: 187 year: 2020 ident: 10.1016/j.jclinepi.2024.111469_bib70 article-title: Fatigue, quality of life and physical fitness following an exercise intervention in multiple myeloma survivors (MASCOT): an exploratory randomised Phase 2 trial utilising a modified Zelen design publication-title: Br J Cancer doi: 10.1038/s41416-020-0866-y contributor: fullname: Koutoukidis – volume: 59 start-page: 988 issue: 5 year: 2020 ident: 10.1016/j.jclinepi.2024.111469_bib32 article-title: Role of good oral hygiene on clinical evolution of rheumatoid arthritis: a randomized study nested in the ESPOIR cohort publication-title: Rheumatology doi: 10.1093/rheumatology/kez368 contributor: fullname: Mariette – volume: 22 start-page: 313 issue: 3 year: 2020 ident: 10.1016/j.jclinepi.2024.111469_bib60 article-title: Feasibility and efficacy of a hospital-based violence intervention program on reducing repeat violent injury in youth: a randomized control trial publication-title: CJEM doi: 10.1017/cem.2019.406 contributor: fullname: Snider – volume: 42 start-page: 377 issue: 2 year: 2009 ident: 10.1016/j.jclinepi.2024.111469_bib22 article-title: Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support publication-title: J Biomed Inform doi: 10.1016/j.jbi.2008.08.010 contributor: fullname: Harris – volume: 159 start-page: 1137 issue: 6 year: 2018 ident: 10.1016/j.jclinepi.2024.111469_bib28 article-title: The effectiveness of a healthy lifestyle intervention, for chronic low back pain: a randomised controlled trial. Journal article publication-title: Pain doi: 10.1097/j.pain.0000000000001198 contributor: fullname: Williams – volume: 109 start-page: 1081 issue: 11 year: 2022 ident: 10.1016/j.jclinepi.2024.111469_bib53 article-title: SPONGE-assisted versus Trendelenburg position surgery in laparoscopic sigmoid and rectal cancer surgery (SPONGE trial): randomized clinical trial publication-title: Bri J Surg doi: 10.1093/bjs/znac249 contributor: fullname: Fahim – volume: 76 start-page: 725 issue: 4 year: 2021 ident: 10.1016/j.jclinepi.2024.111469_bib59 article-title: Women's health initiative strong and healthy pragmatic physical activity intervention trial for cardiovascular disease prevention: design and baseline characteristics. Journal article; clinical trial protocol publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glaa325 contributor: fullname: Stefanick – volume: 18 start-page: 299 issue: 1 year: 2017 ident: 10.1016/j.jclinepi.2024.111469_bib38 article-title: Depressed patients treated by homeopaths: a randomised controlled trial using the "cohort multiple randomised controlled trial" (cmRCT) design. Article publication-title: Trials doi: 10.1186/s13063-017-2040-2 contributor: fullname: Viksveen |
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Title | Characteristics, consent patterns, and challenges of randomized trials using the Trials within Cohorts (TwiCs) design - A scoping review |
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