Anti-DR5 mAb ameliorate adjuvant arthritis rats through inducing synovial cells apoptosis

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 234; no. 12; p. 1468
• Main Authors: Li, Wenzhu, Liu, Zhongchen, Zhuang, Guohong, Yin, Ping, Tao, Huiran, Qiu, Jinghua, Hu, Qingzhong, Zhang, Jiakai
• Format: Journal Article
• Language: English
• Published: England 01.12.2009
• Subjects: Animals; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacology; Apoptosis - drug effects; Apoptosis - immunology; Arthritis, Experimental - chemically induced; Arthritis, Experimental - drug therapy; Arthritis, Experimental - immunology; Arthritis, Experimental - metabolism; bcl-2-Associated X Protein - biosynthesis; bcl-2-Associated X Protein - immunology; Caspases - biosynthesis; Caspases - immunology; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; Genes, myc - immunology; Male; Mitogen-Activated Protein Kinase 9 - biosynthesis; Mitogen-Activated Protein Kinase 9 - immunology; Proto-Oncogene Proteins c-jun - biosynthesis; Proto-Oncogene Proteins c-jun - immunology; RANK Ligand - biosynthesis; RANK Ligand - immunology; Rats; Rats, Sprague-Dawley; Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis; Receptors, TNF-Related Apoptosis-Inducing Ligand - immunology; Synovial Fluid - immunology; Synovial Fluid - metabolism; Tumor Suppressor Protein p53 - biosynthesis; Tumor Suppressor Protein p53 - immunology

Study the therapeutic effects and immunoregulatory mechanisms of anti-DR5 mAb on adjuvant arthritis (AA) rats. AA rats induced by CFA, were treated with anti-DR5 mAb through mainline administration. Effect on the synovial membranes of the tissues was detected by H&E staining. Flow cytometry and...