The role of phosphatidylethanolamine-binding protein (PEBP) family in various diseases: Mechanisms and therapeutic potential
This article focuses on the phosphatidylethanolamine-binding protein (PEBP) family proteins, detailing PEBP1 and PEBP4 due to limited information on PEBP2 and PEBP3, in cellular signaling pathways and research in a spectrum of pathologies, including diverse cancers, metabolic disorders, immunologica...
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| Published in | Progress in biophysics and molecular biology Vol. 196; pp. 102 - 113 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.06.2025
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0079-6107 1873-1732 1873-1732 |
| DOI | 10.1016/j.pbiomolbio.2025.04.002 |
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| Abstract | This article focuses on the phosphatidylethanolamine-binding protein (PEBP) family proteins, detailing PEBP1 and PEBP4 due to limited information on PEBP2 and PEBP3, in cellular signaling pathways and research in a spectrum of pathologies, including diverse cancers, metabolic disorders, immunological diseases and a subset of organ-specific diseases. It outlines the mechanisms through which PEBP1 and PEBP4 regulate essential signaling pathways that are critical for cellular processes such as proliferation, apoptosis, and metastasis. Recent advancements have shown further understanding of these proteins' roles in pathophysiology and their potential as future therapeutic targets. The findings suggest that the impact of PEBP1 and PEBP4 on the course of different diseases has underscored their potential for more in-depth medical research and novel clinically targeted therapies.
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•Phosphatidylethanolamine-binding protein family is a crucial factor in disease cellular processes.•PEBP1 impacts diseases like cancer, metabolic disorders, and neurodegeneration via ERK/NF-κB inhibition.•PEBP4 promotes cancer cell survival and apoptosis resistance, with overexpression linked to tumor occurrence and metastasis. |
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| AbstractList | This article focuses on the phosphatidylethanolamine-binding protein (PEBP) family proteins, detailing PEBP1 and PEBP4 due to limited information on PEBP2 and PEBP3, in cellular signaling pathways and research in a spectrum of pathologies, including diverse cancers, metabolic disorders, immunological diseases and a subset of organ-specific diseases. It outlines the mechanisms through which PEBP1 and PEBP4 regulate essential signaling pathways that are critical for cellular processes such as proliferation, apoptosis, and metastasis. Recent advancements have shown further understanding of these proteins' roles in pathophysiology and their potential as future therapeutic targets. The findings suggest that the impact of PEBP1 and PEBP4 on the course of different diseases has underscored their potential for more in-depth medical research and novel clinically targeted therapies.This article focuses on the phosphatidylethanolamine-binding protein (PEBP) family proteins, detailing PEBP1 and PEBP4 due to limited information on PEBP2 and PEBP3, in cellular signaling pathways and research in a spectrum of pathologies, including diverse cancers, metabolic disorders, immunological diseases and a subset of organ-specific diseases. It outlines the mechanisms through which PEBP1 and PEBP4 regulate essential signaling pathways that are critical for cellular processes such as proliferation, apoptosis, and metastasis. Recent advancements have shown further understanding of these proteins' roles in pathophysiology and their potential as future therapeutic targets. The findings suggest that the impact of PEBP1 and PEBP4 on the course of different diseases has underscored their potential for more in-depth medical research and novel clinically targeted therapies. This article focuses on the phosphatidylethanolamine-binding protein (PEBP) family proteins, detailing PEBP1 and PEBP4 due to limited information on PEBP2 and PEBP3, in cellular signaling pathways and research in a spectrum of pathologies, including diverse cancers, metabolic disorders, immunological diseases and a subset of organ-specific diseases. It outlines the mechanisms through which PEBP1 and PEBP4 regulate essential signaling pathways that are critical for cellular processes such as proliferation, apoptosis, and metastasis. Recent advancements have shown further understanding of these proteins' roles in pathophysiology and their potential as future therapeutic targets. The findings suggest that the impact of PEBP1 and PEBP4 on the course of different diseases has underscored their potential for more in-depth medical research and novel clinically targeted therapies. This article focuses on the phosphatidylethanolamine-binding protein (PEBP) family proteins, detailing PEBP1 and PEBP4 due to limited information on PEBP2 and PEBP3, in cellular signaling pathways and research in a spectrum of pathologies, including diverse cancers, metabolic disorders, immunological diseases and a subset of organ-specific diseases. It outlines the mechanisms through which PEBP1 and PEBP4 regulate essential signaling pathways that are critical for cellular processes such as proliferation, apoptosis, and metastasis. Recent advancements have shown further understanding of these proteins' roles in pathophysiology and their potential as future therapeutic targets. The findings suggest that the impact of PEBP1 and PEBP4 on the course of different diseases has underscored their potential for more in-depth medical research and novel clinically targeted therapies. [Display omitted] •Phosphatidylethanolamine-binding protein family is a crucial factor in disease cellular processes.•PEBP1 impacts diseases like cancer, metabolic disorders, and neurodegeneration via ERK/NF-κB inhibition.•PEBP4 promotes cancer cell survival and apoptosis resistance, with overexpression linked to tumor occurrence and metastasis. |
| Author | Luo, Yanqun Wu, Tao Teng, Yeying Xue, Haiping Deng, Xiaoliang |
| Author_xml | – sequence: 1 givenname: Yeying orcidid: 0009-0009-0948-5570 surname: Teng fullname: Teng, Yeying organization: Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China – sequence: 2 givenname: Haiping surname: Xue fullname: Xue, Haiping organization: Industrial Development Center, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China – sequence: 3 givenname: Xiaoliang surname: Deng fullname: Deng, Xiaoliang organization: Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China – sequence: 4 givenname: Yanqun surname: Luo fullname: Luo, Yanqun organization: Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China – sequence: 5 givenname: Tao orcidid: 0000-0003-1567-1512 surname: Wu fullname: Wu, Tao email: tw827@shutcm.edu.cn, wutao001827@163.com organization: Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40220872$$D View this record in MEDLINE/PubMed |
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| Keywords | Signal pathway PEBP Liver disease Cancer |
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| SubjectTerms | Animals Cancer Humans Liver disease Neoplasms - metabolism Neoplasms - pathology PEBP Phosphatidylethanolamine Binding Protein - metabolism Signal pathway Signal Transduction |
| Title | The role of phosphatidylethanolamine-binding protein (PEBP) family in various diseases: Mechanisms and therapeutic potential |
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