Enantioselective remote C–H activation directed by a chiral cation

• Published in: Science (American Association for the Advancement of Science) Vol. 367; no. 6483; pp. 1246 - 1251
• Main Authors: Genov, Georgi R., Douthwaite, James L., Lahdenperä, Antti S. K., Gibson, David C., Phipps, Robert J.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 13.03.2020
• Subjects: Anions; Aromatic compounds; Asymmetry; Carbon; Catalysts; Cations; Coordination compounds; Enantiomers; Ions; Iridium; Iridium compounds; Ligands; Metal complexes; Negative ions; Phosphorus; Positive ions; Quinine; Strategy; Transition metals

Numerous positively charged metal catalysts have been paired with chiral negative ions to select for just one of two mirror-image products. Genov et al. now report a potentially general strategy to invert the charges in this paradigm. Because intrinsically negative metal catalysts are comparatively...