Ability of donor splenocytes with costimulation blockade to induce mixed hematopoietic chimerism and transplantation tolerance

• Published in: Transplantation proceedings Vol. 36; no. 8; pp. 2423 - 2424
• Main Authors: Shirasugi, N., Emmanouilidis, N., Pearson, T.C., Larsen, C.P.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2004; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Lymphocyte Transfusion; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Animal; Skin Transplantation - immunology; Stem Cell Transplantation; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Transplantation Chimera; Transplantation, Homologous; Human; Tolerance; Splenocyte; Transplantation; Homotransplantation; Medicine; Treatment; Donor; Mixed; Costimulation; Surgery; Graft; Chimerism

We reported stable mixed chimerism and specific tolerance to a fully allogeneic graft after a minimally myelosuppressive regimen including costimulation blockade (CB), donor bone marrow cells (BMC), and busulfan (Bu), a chemotherapeutic conditioning agent that makes niches for engraftment of BMC. Fo...