Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components

• Published in: World journal of gastroenterology : WJG Vol. 15; no. 47; pp. 5992 - 5999
• Main Authors: Gong, Han-Lin, Tang, Wen-Fu, Yu, Qin, Xiang, Jin, Xia, Qing, Chen, Guang-Yuan, Huang, Xi, Liang, Mao-Zhi
• Format: Journal Article
• Language: English
• Published: United States Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University,Chengdu 610041, Sichuan Province, China%Department of Clinical Pharmacology, West China Hospital, Sichuan University,Chengdu 610041, Sichuan Province, China 21.12.2009; The WJG Press and Baishideng
• Subjects: Animals; Anthraquinones - blood; Anti-Inflammatory Agents, Non-Steroidal - blood; Biphenyl Compounds - blood; Brief; Enzyme Inhibitors - blood; Flavanones - blood; Glucosides - blood; Hesperidin - blood; Humans; Lignans - blood; Male; Molecular Structure; Mutagens - metabolism; Pancreatitis, Acute Necrotizing - blood; Pancreatitis, Acute Necrotizing - drug therapy; Plant Extracts - metabolism; Plant Extracts - pharmacokinetics; Random Allocation; Rats; Rats, Sprague-Dawley; SAP公司; 大承气汤; 急性胰腺炎; 组成部分; 药代动力学; 高效液相色谱法; Components; Severe acute pancreatitis; Pharmacokinetics; Da-Cheng-Qi Decoction

AIM：To investigate the effect of severe acute pan- creatitis（SAP）on pharmacokinetics of Da-Cheng-Qi Decoction（DCQD）components in rats. METHODS：Rats were divided into SAP group and sham-operation group as a control group（n=6）. Rhein,chrysophanol,rheochrysidin,magnolol,hesperidin and naringin in DCQD...