Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components

• Published in: World journal of gastroenterology : WJG Vol. 15; no. 47; pp. 5992 - 5999
• Main Authors: Gong, Han-Lin, Tang, Wen-Fu, Yu, Qin, Xiang, Jin, Xia, Qing, Chen, Guang-Yuan, Huang, Xi, Liang, Mao-Zhi
• Format: Journal Article
• Language: English
• Published: United States Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University,Chengdu 610041, Sichuan Province, China%Department of Clinical Pharmacology, West China Hospital, Sichuan University,Chengdu 610041, Sichuan Province, China 21.12.2009; The WJG Press and Baishideng
• Subjects: Animals; Anthraquinones - blood; Anti-Inflammatory Agents, Non-Steroidal - blood; Biphenyl Compounds - blood; Brief; Enzyme Inhibitors - blood; Flavanones - blood; Glucosides - blood; Hesperidin - blood; Humans; Lignans - blood; Male; Molecular Structure; Mutagens - metabolism; Pancreatitis, Acute Necrotizing - blood; Pancreatitis, Acute Necrotizing - drug therapy; Plant Extracts - metabolism; Plant Extracts - pharmacokinetics; Random Allocation; Rats; Rats, Sprague-Dawley; SAP公司; 大承气汤; 急性胰腺炎; 组成部分; 药代动力学; 高效液相色谱法; Components; Severe acute pancreatitis; Pharmacokinetics; Da-Cheng-Qi Decoction
• DOI: 10.3748/wjg.15.5992
• ISSN: 1007-9327; 2219-2840

AIM：To investigate the effect of severe acute pan- creatitis（SAP）on pharmacokinetics of Da-Cheng-Qi Decoction（DCQD）components in rats. METHODS：Rats were divided into SAP group and sham-operation group as a control group（n=6）. Rhein,chrysophanol,rheochrysidin,magnolol,hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS：Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage.The Cmax（chrysophanol,P= 0.0059;rheochrysidin,P=0.0288;magnolol,P= 0.0487;hesperidin,P=0.0277;naringin,P=0.0023） and AUC（rhein,P=0.0186;chrysophanol,P=0.0013; magnolol,P=0.001;hesperidin,P=0.0081;naringin, P=0.0272）of DCQD component were obviously lower in SAP group than in control group.The T1/2α of chrysophanol and rheochrysidin（P=0.0467 and 0.0005,respectively）and Tmax of chrysophanol and rheochrysidin（P=0.0101 and 0.0037,respectively） lasted longer in SAP group than in control group. CONCLUSION：SAP can significantly impact the ab-sorption of DCQD components in rats and their phar-macokinetic parameters.