Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress

• Published in: Antioxidants & redox signaling Vol. 31; no. 1; p. 75
• Main Authors: Feng, Han, Wang, Jin-Yu, Yu, Bo, Cong, Xin, Zhang, Wei-Guang, Li, Li, Liu, Li-Mei, Zhou, Yun, Zhang, Cheng-Lin, Gu, Pei-Liang, Wu, Li-Ling
• Format: Journal Article
• Language: English
• Published: United States 01.07.2019
• Subjects: chronic kidney disease; PGC-1α; mitochondrial reactive oxygen species; sirtuin 3; vascular calcification

Vascular calcification is associated with cardiovascular death in patients with chronic kidney disease (CKD). Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) plays an important role in various cardiovascular diseases. However, its role in vascular calcification remains unknown....