Metabolomics analysis of Pulsatilla decoction on treatment of wetness‐heat‐induced diarrhea in rats based on UPLC–Q/TOF–MS/MS

• Published in: Biomedical chromatography Vol. 33; no. 11; pp. e4629 - n/a
• Main Authors: Hua, Yong‐li, Ma, Qi, Li, Wei, Zhang, Xiao‐song, Cheng, Xiao‐hua, Jia, Ya‐qian, Peng, Xiao‐ting, Yao, Wan‐ling, Ji, Peng, Hu, Jun‐jie, Wei, Yan‐ming
• Format: Journal Article
• Language: English
• Published: England 01.11.2019
• Subjects: Animals; Chromatography, High Pressure Liquid; Cytokines - blood; Diarrhea - etiology; Diarrhea - metabolism; Drugs, Chinese Herbal - pharmacology; Female; Hot Temperature - adverse effects; Male; Metabolome - drug effects; Metabolomics; Pulsatilla; Pulsatilla decoction; Rats; Rats, Wistar; Reproducibility of Results; Tandem Mass Spectrometry; UPLC–Q/TOF–MS/MS; wetness‐heat induced diarrhea; Pulsatilla decoction; UPLC-Q/TOF-MS/MS; wetness-heat induced diarrhea; metabolomics

Pulsatilla decoction (PD) is a classical prescription in traditional Chinese medicine that has therapeutic effects on wetness‐heat‐induced diarrhea (WHD). To investigate the therapeutic effects of PD in the treatment of WHD and elucidate the potential mechanism, we used a metabolomics strategy on th...