Autoreactive T cells in mercury-induced autoimmune disease: in vitro demonstration

• Published in: The Journal of immunology (1950) Vol. 137; no. 8; pp. 2548 - 2554
• Main Authors: Pelletier, L, Pasquier, R, Hirsch, F, Sapin, C, Druet, P
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Assoc Immnol 15.10.1986; American Association of Immunologists
• Subjects: Animals; Antibodies, Monoclonal; Autoimmune Diseases - chemically induced; Autoimmune Diseases - immunology; B-Lymphocytes - immunology; Biological and medical sciences; Fluorescent Antibody Technique; Glomerulonephritis; In Vitro Techniques; Lymph Nodes - immunology; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Medical sciences; Mercuric Chloride - toxicity; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Rats; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Glomerulonephritis; Immunopathology; Urinary system disease; Rat; Pathogenesis; Rodentia; Autoimmune disease; Autologous system; Vertebrata; Mixed cell culture; Experimental disease; Mammalia; Immunological investigation; Mercury II Chlorides; Animal; T»-Lymphocyte

Mercuric chloride induces in Brown-Norway rats an autoimmune disease due to a T dependent polyclonal activation of B cells. Various autoantibodies and a striking increase in total serum IgE level are observed as consequences of this polyclonal activation. The aim of this study was to investigate the...