Epigenetic underpinnings of the autistic mind: Histone modifications and prefrontal excitation/inhibition imbalance

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 195; no. 8; pp. e32986 - n/a
• Main Authors: Fard, Yasaman Arman, Sadeghi, Elham Najjar, Pajoohesh, Zohreh, Gharehdaghi, Zahra, Khatibi, Dorsa Mousavi, Khosravifar, Shaghayegh, Pishkari, Yasamin, Nozari, Shadi, Hijazi, Ahmed, Pakmehr, SeyedAbbas, Shayan, Sepideh Karkon
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.12.2024; Wiley Subscription Services, Inc
• Subjects: Autism; autism spectrum disorder; Autism Spectrum Disorder - genetics; Autism Spectrum Disorder - metabolism; Autistic Disorder - genetics; Autistic Disorder - metabolism; Autistic Disorder - physiopathology; EGR-1 protein; Epigenesis, Genetic; Epigenetics; excitation/inhibition imbalance; Executive function; Gene expression; Histone Code - genetics; Histone H3; histone modifications; Histones; Histones - genetics; Histones - metabolism; Humans; Molecular modelling; Prefrontal cortex; Prefrontal Cortex - metabolism; Regulatory sequences; Synaptic transmission; Synaptic Transmission - genetics; Synaptogenesis; excitation/inhibition imbalance; histone modifications; autism spectrum disorder; prefrontal cortex; epigenetics

Autism spectrum disorder (ASD) is complex neurobehavioral condition influenced by several cellular and molecular mechanisms that are often concerned with synaptogenesis and synaptic activity. Based on the excitation/inhibition (E/I) imbalance theory, ASD could be the result of disruption in excitato...