Comparative Intra‐Subject Analysis of Gene Expression and Protein Abundance of Major and Minor Drug Metabolizing Enzymes in Healthy Human Jejunum and Liver

• Published in: Clinical pharmacology and therapeutics Vol. 115; no. 2; pp. 221 - 230
• Main Authors: Wenzel, Christoph, Lapczuk‐Romanska, Joanna, Malinowski, Damian, Ostrowski, Marek, Drozdzik, Marek, Oswald, Stefan
• Format: Journal Article
• Language: English
• Published: United States 01.02.2024
• Subjects: Cytochrome P-450 CYP3A - genetics; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; Female; Gene Expression; Humans; Imidazoles; Jejunum - metabolism; Liver - metabolism; Male; Organosilicon Compounds

First pass metabolism by phase I and phase II enzymes in the intestines and liver is a major determinant of the oral bioavailability of many drugs. Several studies analyzed expressions of major drug‐metabolizing enzymes (DMEs), such as CYP3A4 and UGT1A1 in the human gut and liver. However, there is...