Metastatic Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patient: A Systematic Review
Patients who are immunosuppressed, such as solid organ transplant recipients (SOTRs), are at a higher risk of developing cutaneous squamous cell carcinoma (cSCC). This population is at a higher risk of metastasis and worse disease-specific survival. The objective of this review is to better characte...
Saved in:
| Published in | JID innovations Vol. 4; no. 5; p. 100294 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
01.09.2024
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Patients who are immunosuppressed, such as solid organ transplant recipients (SOTRs), are at a higher risk of developing cutaneous squamous cell carcinoma (cSCC). This population is at a higher risk of metastasis and worse disease-specific survival. The objective of this review is to better characterize the immunosuppressed population with metastatic cSCC. A literature search was conducted to identify reports of lymphatic metastases in immunosuppressed patients with cSCC. Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed during creation of a cohort with desired inclusion and exclusion criteria. One hundred and thirty-five articles met the inclusion/exclusion criteria, yielding 1020 total cases. We discovered that the most common forms of immunosuppression within the cohort were solid organ transplantation and hematologic malignancy. White males and cSCC tumors involving the head and neck comprised most cases. Using Brigham and Women’s Hospital and Eighth edition of American Joint Committee on Cancer tumor staging criteria, we observed a trend toward higher stage tumors in SOTR than in patients with hematologic malignancy. This review confirms that known clinical risk factors for metastatic cSCC appear to be similar among the immunosuppressed population and the cSCC population at large. Interestingly, our data suggest that current staging systems may not accurately reflect metastatic risk among patients with hematologic malignancy. |
|---|---|
| AbstractList | Patients who are immunosuppressed, such as solid organ transplant recipients (SOTRs), are at a higher risk of developing cutaneous squamous cell carcinoma (cSCC). This population is at a higher risk of metastasis and worse disease-specific survival. The objective of this review is to better characterize the immunosuppressed population with metastatic cSCC. A literature search was conducted to identify reports of lymphatic metastases in immunosuppressed patients with cSCC. Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed during creation of a cohort with desired inclusion and exclusion criteria. One hundred and thirty-five articles met the inclusion/exclusion criteria, yielding 1020 total cases. We discovered that the most common forms of immunosuppression within the cohort were solid organ transplantation and hematologic malignancy. White males and cSCC tumors involving the head and neck comprised most cases. Using Brigham and Women's Hospital and Eighth edition of American Joint Committee on Cancer tumor staging criteria, we observed a trend toward higher stage tumors in SOTR than in patients with hematologic malignancy. This review confirms that known clinical risk factors for metastatic cSCC appear to be similar among the immunosuppressed population and the cSCC population at large. Interestingly, our data suggest that current staging systems may not accurately reflect metastatic risk among patients with hematologic malignancy. Patients who are immunosuppressed, such as solid organ transplant recipients (SOTRs), are at a higher risk of developing cutaneous squamous cell carcinoma (cSCC). This population is at a higher risk of metastasis and worse disease-specific survival. The objective of this review is to better characterize the immunosuppressed population with metastatic cSCC. A literature search was conducted to identify reports of lymphatic metastases in immunosuppressed patients with cSCC. Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed during creation of a cohort with desired inclusion and exclusion criteria. One hundred and thirty-five articles met the inclusion/exclusion criteria, yielding 1020 total cases. We discovered that the most common forms of immunosuppression within the cohort were solid organ transplantation and hematologic malignancy. White males and cSCC tumors involving the head and neck comprised most cases. Using Brigham and Women's Hospital and Eighth edition of American Joint Committee on Cancer tumor staging criteria, we observed a trend toward higher stage tumors in SOTR than in patients with hematologic malignancy. This review confirms that known clinical risk factors for metastatic cSCC appear to be similar among the immunosuppressed population and the cSCC population at large. Interestingly, our data suggest that current staging systems may not accurately reflect metastatic risk among patients with hematologic malignancy.Patients who are immunosuppressed, such as solid organ transplant recipients (SOTRs), are at a higher risk of developing cutaneous squamous cell carcinoma (cSCC). This population is at a higher risk of metastasis and worse disease-specific survival. The objective of this review is to better characterize the immunosuppressed population with metastatic cSCC. A literature search was conducted to identify reports of lymphatic metastases in immunosuppressed patients with cSCC. Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed during creation of a cohort with desired inclusion and exclusion criteria. One hundred and thirty-five articles met the inclusion/exclusion criteria, yielding 1020 total cases. We discovered that the most common forms of immunosuppression within the cohort were solid organ transplantation and hematologic malignancy. White males and cSCC tumors involving the head and neck comprised most cases. Using Brigham and Women's Hospital and Eighth edition of American Joint Committee on Cancer tumor staging criteria, we observed a trend toward higher stage tumors in SOTR than in patients with hematologic malignancy. This review confirms that known clinical risk factors for metastatic cSCC appear to be similar among the immunosuppressed population and the cSCC population at large. Interestingly, our data suggest that current staging systems may not accurately reflect metastatic risk among patients with hematologic malignancy. |
| ArticleNumber | 100294 |
| Author | Zheng, Cheng Whitley, Melodi J. Wysong, Ashley Schmidt, Cynthia M. Wackel, Megan Thomas, Sierra |
| Author_xml | – sequence: 1 givenname: Megan orcidid: 0000-0002-9107-0981 surname: Wackel fullname: Wackel, Megan organization: Department of Dermatology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA – sequence: 2 givenname: Sierra orcidid: 0009-0009-9229-343X surname: Thomas fullname: Thomas, Sierra organization: Department of Dermatology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA – sequence: 3 givenname: Cynthia M. orcidid: 0000-0003-1657-2671 surname: Schmidt fullname: Schmidt, Cynthia M. organization: Leon S. McGoogan Heath Sciences Library, University of Nebraska Medical Center, Omaha, Nebraska, USA – sequence: 4 givenname: Cheng orcidid: 0000-0002-6562-870X surname: Zheng fullname: Zheng, Cheng organization: Department of Biostatistics, College of Public health, University of Nebraska Medical Center, Omaha, Nebraska, USA – sequence: 5 givenname: Ashley orcidid: 0000-0001-5131-1149 surname: Wysong fullname: Wysong, Ashley organization: Department of Dermatology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA – sequence: 6 givenname: Melodi J. orcidid: 0000-0002-8163-6881 surname: Whitley fullname: Whitley, Melodi J. email: melodi.whitley@duke.edu organization: Department of Dermatology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39258287$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kVtv1DAQhS1UREvpL0BCeeRlF9_iCxJCVVTKSkUgCo_IcpxJcZTEWzsp9N_XuylV-8KTrfGZb8bnvEQHYxgBodcErwkm4l23_tv5xq8ppjxXMNX8GTqiQsgVpkIePLofopOUOpw1JWGU6xfokGlaKqrkEfr1BSabJjt5V1TzZEcIcyour2c77C4V9H1R2ej8GAZb-LHYDMM8hjRvtxFSgqb4lnthnN4Xp8XlbZpg2LO-w42HP6_Q89b2CU7uz2P089PZj-rz6uLr-aY6vVg5RglftVwoQrlUVlPBNLS4drXmlgoQtaCC5CLnmrC2xI222CnllJay5LUChwk7RpuF2wTbmW30g423Jlhv9oUQr4yNea0ejFKKO2sldy3j3NFa8rJV2lnKG6mdyqyPC2s71wM0Lv8t2v4J9OnL6H-bq3BjCGGqlCXNhLf3hBiuZ0iTGXxy2cnFXcMIpkpRrcssZYvUxZBShPZhDsFmF7TpzD5oswvaLEHnrjePV3zo-RdrFnxYBJBNz0FEk1wOyUHjI7gpu-L_O-AO1-u8OA |
| Cites_doi | 10.1016/j.jaad.2012.11.037 10.1097/DSS.0000000000001828 10.1001/jamadermatol.2019.0032 10.1016/j.jaad.2017.08.059 10.1016/S1470-2045(08)70178-5 10.1001/archderm.142.6.755 10.1056/NEJMra2206348 10.1001/jamadermatol.2013.6249 10.1016/j.jaut.2018.11.001 10.1002/cncr.21898 10.1016/j.hoc.2018.08.001 10.1001/jamaoto.2019.3751 |
| ContentType | Journal Article |
| Copyright | 2024 The Authors 2024 The Authors. 2024 The Authors 2024 |
| Copyright_xml | – notice: 2024 The Authors – notice: 2024 The Authors. – notice: 2024 The Authors 2024 |
| DBID | 6I. AAFTH NPM AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.1016/j.xjidi.2024.100294 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2667-0267 |
| ExternalDocumentID | oai_doaj_org_article_8884caa74cf344c2b745f89ca24d79c8 10_1016_j_xjidi_2024_100294 39258287 S2667026724000419 |
| Genre | Journal Article Review |
| GroupedDBID | .1- .FO 0R~ 0SF 6I. AAEDW AAFTH AALRI AAXUO ADVLN AFRHN AITUG AJUYK ALMA_UNASSIGNED_HOLDINGS AMRAJ EBS FDB GROUPED_DOAJ M~E ROL RPM Z5R AFJKZ NPM AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c3214-f46812478a92639ef0bcb94a26e6b626163944913f50d9a0c88c897754b8ec013 |
| IEDL.DBID | RPM |
| ISSN | 2667-0267 |
| IngestDate | Tue Oct 22 15:09:05 EDT 2024 Wed Sep 11 06:04:34 EDT 2024 Sat Sep 14 18:09:19 EDT 2024 Thu Sep 26 20:25:53 EDT 2024 Wed Oct 23 09:46:19 EDT 2024 Sat Sep 14 18:13:08 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Squamous cell carcinoma BWH DSD AJCC8 GRADE PNI Metastasis SOTR Immunodeficiencies cSCC PET |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. 2024 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3214-f46812478a92639ef0bcb94a26e6b626163944913f50d9a0c88c897754b8ec013 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0001-5131-1149 0009-0009-9229-343X 0000-0003-1657-2671 0000-0002-9107-0981 0000-0002-6562-870X 0000-0002-8163-6881 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11385752/ |
| PMID | 39258287 |
| PQID | 3102882995 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_8884caa74cf344c2b745f89ca24d79c8 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11385752 proquest_miscellaneous_3102882995 crossref_primary_10_1016_j_xjidi_2024_100294 pubmed_primary_39258287 elsevier_sciencedirect_doi_10_1016_j_xjidi_2024_100294 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-Sep |
| PublicationDateYYYYMMDD | 2024-09-01 |
| PublicationDate_xml | – month: 09 year: 2024 text: 2024-Sep |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | JID innovations |
| PublicationTitleAlternate | JID Innov |
| PublicationYear | 2024 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Cooper, Brown (bib2) 2006; 142 Brantsch, Meisner, Schönfisch, Trilling, Wehner-Caroli, Röcken (bib1) 2008; 9 Tam, Yao, Amit, Gajera, Luo, Treistman (bib9) 2020; 146 Ruiz, Karia, Besaw, Schmults (bib7) 2019; 155 Veness (bib11) 2007; 2007 Wysong (bib14) 2023; 388 Que, Zwald, Schmults (bib6) 2018; 78 Veness, Palme, Morgan (bib12) 2006; 106 Velez, Karia, Vartanov, Davids, Brown, Schmults (bib10) 2014; 150 Waldman, Schmults (bib13) 2019; 33 Karia, Han, Schmults (bib5) 2013; 68 Feinstein, Higgins, Ahadiat, Wysong (bib4) 2019; 45 Fava, Petri (bib3) 2019; 96 Ryan, Hill (bib8) 2016 Tam (10.1016/j.xjidi.2024.100294_bib9) 2020; 146 Ruiz (10.1016/j.xjidi.2024.100294_bib7) 2019; 155 Veness (10.1016/j.xjidi.2024.100294_bib11) 2007; 2007 Cooper (10.1016/j.xjidi.2024.100294_bib2) 2006; 142 Ryan (10.1016/j.xjidi.2024.100294_bib8) Wysong (10.1016/j.xjidi.2024.100294_bib14) 2023; 388 Velez (10.1016/j.xjidi.2024.100294_bib10) 2014; 150 Waldman (10.1016/j.xjidi.2024.100294_bib13) 2019; 33 Veness (10.1016/j.xjidi.2024.100294_bib12) 2006; 106 Fava (10.1016/j.xjidi.2024.100294_bib3) 2019; 96 Feinstein (10.1016/j.xjidi.2024.100294_bib4) 2019; 45 Karia (10.1016/j.xjidi.2024.100294_bib5) 2013; 68 Que (10.1016/j.xjidi.2024.100294_bib6) 2018; 78 Brantsch (10.1016/j.xjidi.2024.100294_bib1) 2008; 9 |
| References_xml | – volume: 142 start-page: 755 year: 2006 end-page: 758 ident: bib2 article-title: Special concern about squamous cell carcinoma of the scalp in organ transplant recipients publication-title: Arch Dermatol contributor: fullname: Brown – volume: 146 start-page: 128 year: 2020 end-page: 135 ident: bib9 article-title: Association of immunosuppression with outcomes of patients with cutaneous squamous cell carcinoma of the head and neck publication-title: JAMA Otolaryngol Head Neck Surg contributor: fullname: Treistman – volume: 9 start-page: 713 year: 2008 end-page: 720 ident: bib1 article-title: Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study publication-title: Lancet Oncol contributor: fullname: Röcken – volume: 106 start-page: 2389 year: 2006 end-page: 2396 ident: bib12 article-title: High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease publication-title: Cancer contributor: fullname: Morgan – volume: 388 start-page: 2262 year: 2023 end-page: 2273 ident: bib14 article-title: Squamous-cell carcinoma of the skin publication-title: N Engl J Med contributor: fullname: Wysong – volume: 45 start-page: 772 year: 2019 end-page: 781 ident: bib4 article-title: A retrospective cohort study of cutaneous squamous cell carcinoma with lymph node metastasis: risk factors and clinical course publication-title: Dermatol Surg contributor: fullname: Wysong – volume: 155 start-page: 819 year: 2019 end-page: 825 ident: bib7 article-title: Performance of the American Joint Committee on cancer staging manual, 8th edition vs the Brigham and Women’s Hospital tumor classification system for cutaneous squamous cell carcinoma publication-title: JAMA Dermatol contributor: fullname: Schmults – volume: 150 start-page: 280 year: 2014 end-page: 287 ident: bib10 article-title: Association of advanced leukemic stage and skin cancer tumor stage with poor skin cancer outcomes in patients with chronic lymphocytic leukemia publication-title: JAMA Dermatol contributor: fullname: Schmults – year: 2016 ident: bib8 article-title: How to GRADE the quality of evidence. Cochrane Consumers and Comminication Group contributor: fullname: Hill – volume: 96 start-page: 1 year: 2019 end-page: 13 ident: bib3 article-title: Systemic lupus erythematosus: diagnosis and clinical management publication-title: J Autoimmun contributor: fullname: Petri – volume: 2007 year: 2007 ident: bib11 article-title: High-risk cutaneous squamous cell carcinoma of the head and neck publication-title: J Biomed Biotechnol contributor: fullname: Veness – volume: 78 start-page: 237 year: 2018 end-page: 247 ident: bib6 article-title: Cutaneous squamous cell carcinoma: incidence, risk factors, diagnosis, and staging publication-title: J Am Acad Dermatol contributor: fullname: Schmults – volume: 33 start-page: 1 year: 2019 end-page: 12 ident: bib13 article-title: Cutaneous squamous cell carcinoma publication-title: Hematol Oncol Clin North Am contributor: fullname: Schmults – volume: 68 start-page: 957 year: 2013 end-page: 966 ident: bib5 article-title: Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012 publication-title: J Am Acad Dermatol contributor: fullname: Schmults – volume: 68 start-page: 957 year: 2013 ident: 10.1016/j.xjidi.2024.100294_bib5 article-title: Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012 publication-title: J Am Acad Dermatol doi: 10.1016/j.jaad.2012.11.037 contributor: fullname: Karia – volume: 45 start-page: 772 year: 2019 ident: 10.1016/j.xjidi.2024.100294_bib4 article-title: A retrospective cohort study of cutaneous squamous cell carcinoma with lymph node metastasis: risk factors and clinical course publication-title: Dermatol Surg doi: 10.1097/DSS.0000000000001828 contributor: fullname: Feinstein – volume: 155 start-page: 819 year: 2019 ident: 10.1016/j.xjidi.2024.100294_bib7 article-title: Performance of the American Joint Committee on cancer staging manual, 8th edition vs the Brigham and Women’s Hospital tumor classification system for cutaneous squamous cell carcinoma publication-title: JAMA Dermatol doi: 10.1001/jamadermatol.2019.0032 contributor: fullname: Ruiz – volume: 78 start-page: 237 year: 2018 ident: 10.1016/j.xjidi.2024.100294_bib6 article-title: Cutaneous squamous cell carcinoma: incidence, risk factors, diagnosis, and staging publication-title: J Am Acad Dermatol doi: 10.1016/j.jaad.2017.08.059 contributor: fullname: Que – volume: 9 start-page: 713 year: 2008 ident: 10.1016/j.xjidi.2024.100294_bib1 article-title: Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study publication-title: Lancet Oncol doi: 10.1016/S1470-2045(08)70178-5 contributor: fullname: Brantsch – volume: 142 start-page: 755 year: 2006 ident: 10.1016/j.xjidi.2024.100294_bib2 article-title: Special concern about squamous cell carcinoma of the scalp in organ transplant recipients publication-title: Arch Dermatol doi: 10.1001/archderm.142.6.755 contributor: fullname: Cooper – volume: 388 start-page: 2262 year: 2023 ident: 10.1016/j.xjidi.2024.100294_bib14 article-title: Squamous-cell carcinoma of the skin publication-title: N Engl J Med doi: 10.1056/NEJMra2206348 contributor: fullname: Wysong – ident: 10.1016/j.xjidi.2024.100294_bib8 contributor: fullname: Ryan – volume: 150 start-page: 280 year: 2014 ident: 10.1016/j.xjidi.2024.100294_bib10 article-title: Association of advanced leukemic stage and skin cancer tumor stage with poor skin cancer outcomes in patients with chronic lymphocytic leukemia publication-title: JAMA Dermatol doi: 10.1001/jamadermatol.2013.6249 contributor: fullname: Velez – volume: 96 start-page: 1 year: 2019 ident: 10.1016/j.xjidi.2024.100294_bib3 article-title: Systemic lupus erythematosus: diagnosis and clinical management publication-title: J Autoimmun doi: 10.1016/j.jaut.2018.11.001 contributor: fullname: Fava – volume: 106 start-page: 2389 year: 2006 ident: 10.1016/j.xjidi.2024.100294_bib12 article-title: High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease publication-title: Cancer doi: 10.1002/cncr.21898 contributor: fullname: Veness – volume: 33 start-page: 1 year: 2019 ident: 10.1016/j.xjidi.2024.100294_bib13 article-title: Cutaneous squamous cell carcinoma publication-title: Hematol Oncol Clin North Am doi: 10.1016/j.hoc.2018.08.001 contributor: fullname: Waldman – volume: 2007 year: 2007 ident: 10.1016/j.xjidi.2024.100294_bib11 article-title: High-risk cutaneous squamous cell carcinoma of the head and neck publication-title: J Biomed Biotechnol contributor: fullname: Veness – volume: 146 start-page: 128 year: 2020 ident: 10.1016/j.xjidi.2024.100294_bib9 article-title: Association of immunosuppression with outcomes of patients with cutaneous squamous cell carcinoma of the head and neck publication-title: JAMA Otolaryngol Head Neck Surg doi: 10.1001/jamaoto.2019.3751 contributor: fullname: Tam |
| SSID | ssj0002513249 |
| Score | 2.32055 |
| SecondaryResourceType | review_article |
| Snippet | Patients who are immunosuppressed, such as solid organ transplant recipients (SOTRs), are at a higher risk of developing cutaneous squamous cell carcinoma... |
| SourceID | doaj pubmedcentral proquest crossref pubmed elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 100294 |
| SubjectTerms | Immunodeficiencies Metastasis Review Squamous cell carcinoma |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEBUlp1xKS9PWzQcK9FjTtSzZUm7pkpAWUgppIJciRh-mDol3k-xCf35nrPWyTiG59GobW5pned54Rm8Y-yiaALFUIYcqOgxQJrikoDY5uoJKBV-KwtF_yPPv1dml_HalrjZafVFNWJIHTob7jBGa9AC19E0ppReulqrRxoOQoTY-bfMt1EYwRd9g9NrIFMwgM9QXdP25bkOLEaGQve6okSNX1Cv2jzzSv4zzceHkhic6fcVerigkP05Df81exO4N-3UeF0C7g1rPp0tkfBFDen5xtwSK7fk03tzwKfUN6ma3wNuOf6WNIbOH5byvhI2B_0gKq0f8mF-s5Z15yh3ssMvTk5_Ts3zVOiEn88q8kaQrJmsNRiAHic3EeWckiCpWDmMYZGFGSlOUjZoEAxOvtdeG1PCcjh5p4Vu21c26-J5x53yITlUAGmQhgvENlFA1ytWR1Poy9mmwop0nhQw7lI5d297oloxuk9Ez9oUsvb6U5K37Awi6XYFunwM9Y9WAk10xhcQA8Fbt008_HFC1uI4oOZIAsSUxLY3OWWXsXUJ5PUbkkJRdrDOmR_iPJjE-07W_e63uoiipB6r48D-mvcu2aS6pxG2PbS3ul3EfOdHCHfSv_1_uSAui priority: 102 providerName: Directory of Open Access Journals |
| Title | Metastatic Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patient: A Systematic Review |
| URI | https://dx.doi.org/10.1016/j.xjidi.2024.100294 https://www.ncbi.nlm.nih.gov/pubmed/39258287 https://www.proquest.com/docview/3102882995/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC11385752 https://doaj.org/article/8884caa74cf344c2b745f89ca24d79c8 |
| Volume | 4 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELXanrggKr4CpXIljqS7iR3H5lYiqoK0qFKp1Auy_BVItZtdyq7Ez2fG3qwaKnHgmsSJPWNn3tjPz4S8LVtvAqt8bkSwkKBMYUiZWuUQCkTlHSsLi_OQsy_i4pp_vqlu9ogY9sJE0r6z3Wk_X5z23Y_IrVwt3GTgiU0uZ01RMDxYspzsk_2asXs5Ov5_IWIDSlCDxFAkc_2-7XwH2WDJo-ao4qMwFNX6R9HoIdr8mzR5LwqdPyGPt_CRnqVqHpK90D8l32ZhbXBnUOdoswG0FyCdp1c_NwbzetqE-Zw2eGZQv1wY2vX0E24KWf7arCILNnh6mdRV39MzerWTdqZp3eAZuT7_-LW5yLfHJuRoWp63HDXFeC2NKgF_hHZqnVXclCIIC_kLIDDFuSpYW029MlMnpZMKlfCsDA4g4XNy0C_78JJQa50PthLGSMOL0ivXGmZEW9k6oFJfRt4NVtSrpI6hB9rYrY5G12h0nYyekQ9o6d2jKG0dLyzvvuutgzWk5NwZU3PXMs5daWtetVI5U3JfKyczIgY_6S1KSNEfXtX9--sng1c1jCFcGEkO0QxRloTAXGXkRfLyro6AH3Flsc6IHPl_1IjxHei2Uad76Kav_r_oa_IIW5BIbUfkYH23CW8ABa3tcZw9OI5d_w_3EQt8 |
| link.rule.ids | 230,315,733,786,790,870,891,2115,27955,27956,53825,53827 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFH4q5QAXFrGlbEbiSGYmjpPY3EpENYVOVamt6AVZ3gJpZ5KhnUiIX4-XyagpEhJc42wv7znve_bnzwBvcaWFSTMdi9xIW6BMbJcSBYttKsgzrVKcSDcOOTvMp6fk01l2tgV5vxbGk_aVrEfNfDFq6u-eW7lcqHHPExsfzcokSd3Gknh8C27bDouza1W6-wPbnG1xAutFhjyd6-d5rWtbD2LiVUcZGSQir9c_yEd_4s2btMlreWjvPnzpLQj0k4tRt5Ij9euGuOO_m_gA7q2hKdoN7Q9hyzSP4OvMrIRbdVQrVHYWSZq2u0LHPzrhxgxQaeZzVLr9iJp2IVDdoH234KS96paeYWs0OgrKre_RLjreyEajMCfxGE73Pp6U03i9JUPs3Ebiiji9MlJQwbDFNqaaSCUZETg3ubS1kUV3jBCWpFU20UxMFKWKMqeyJ6lRFm4-ge2mbcwzQFIqbWSWC0EFSbBmqhKpyKtMFsapAEbwrvcPXwblDd5T0s65dyd37uTBnRF8cD7cnOpks_2B9vIbX39Zbst9ooQoiKpSQhSWBckqypTARBdM0QjyPgL4GoEEZGFvVf_96W_6eOG2f7pJl-AQnjoER23SzyJ4GuJn844Wm7pZyyICOoisgRHDFhsvXgO8j4-d_7_0NdyZnswO-MH-4efncNdZE8hzL2B7ddmZlxZtreQr37V-A8JDLK4 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgSIgXLuIW2MBIPJK2cZzE5m0LVBvQqdKYNAkhy7dARpuUtZEmfj3HcVItQ-Jhr4lzOTnHOd-xP39G6C0pjLRxYkKZWgUFygS6lMx4CKkgTYyOSaTcOOTsOD08pZ_OkrOOVbnuaJWVVuWoWixHVfmz5Vaulnrc88TG81keRbHbWJKMV6YY30Z3oNOS7Eql7v7CkLcBK_BeaKildF2el6aEmpDQVnmU00EyajX7BznpX8x5nTp5JRdNH6BvvRWegvJr1GzUSP-5JvB4MzMfovsdRMX7vs0jdMtWj9H3md1It_qo1DhvAFHaulnjk9-NdGMHOLeLBc7dvkRVvZS4rPCRW3hSr5tVy7S1Bs-9gut7vI9PtvLR2M9NPEGn049f88Ow25ohdO6jYUGdbhnNmOQEMI4tJkorTiVJbaqgRgKUxynlUVwkE8PlRDOmGXdqe4pZDbDzKdqp6so-R1gpbaxKUimZpBExXBcylmmRqMw6NcAAvet9JFZegUP01LRz0bpUOJcK79IAHTg_bps6-ez2QH3xQ3RfV0DZT7WUGdVFTKkmKqNJwbiWhJqMaxagtI8C0SERjzDgVuX_n_6mjxkB_dRNvniHiNghOQbJPwnQMx9D23cEjOpmL7MAsUF0DYwYnoGYabXA-xh5cfNLX6O78w9T8eXo-PNLdM8Z4zl0u2hnc9HYPQBdG_Wq7V1_ARCxLy4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Metastatic+Cutaneous+Squamous+Cell+Carcinoma+in+Immunosuppressed+Patient%3A+A+Systematic+Review&rft.jtitle=JID+innovations&rft.au=Wackel%2C+Megan&rft.au=Thomas%2C+Sierra&rft.au=Schmidt%2C+Cynthia+M.&rft.au=Zheng%2C+Cheng&rft.date=2024-09-01&rft.pub=Elsevier+Inc&rft.issn=2667-0267&rft.eissn=2667-0267&rft.volume=4&rft.issue=5&rft_id=info:doi/10.1016%2Fj.xjidi.2024.100294&rft.externalDocID=S2667026724000419 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2667-0267&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2667-0267&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2667-0267&client=summon |