Biology of telomeres: lessons from budding yeast

• Published in: FEMS microbiology reviews Vol. 38; no. 2; pp. 144 - 171
• Main Author: Kupiec, Martin
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2014; Oxford University Press
• Subjects: aging; Animals; Biology; cancer; Chromosomes; DNA damage response; DNA Replication; Genetics; genome stability; Genomes; Mammals; Molecular biology; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - enzymology; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - physiology; Telomerase; Telomere - genetics; Telomere - metabolism; Telomere - physiology; Telomere Homeostasis - physiology; Telomere-Binding Proteins - genetics; Telomere-Binding Proteins - metabolism; Yeast; Yeasts; genome stability; DNA replication; cancer; aging; DNA damage response

Abstract Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic chromosomes and thereby protect their stability and integrity. Telomeres play central roles in maintaining the genome's integrity, distinguishing between the natural chromosomal ends and unwanted double-s...