Computational analysis of drug like candidates against Neuraminidase of Human Influenza A virus subtypes

Influenza virus is an enveloped virus having segmented genome, coded by eight (negative-sense) RNA segments. The RNA segments are packed in a nucleocapsid protein. Neuraminidase (NA), an exosialidase, is the major antigen as well as vital virulence factor of the virus and is coded by the 6th segment...

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Published inInformatics in medicine unlocked Vol. 18; p. 100284
Main Authors Selvaraj, Gracy Fathima, Piramanayagam, Shanmugavel, Devadasan, Velmurugan, Hassan, Sameer, Krishnasamy, Kaveri, Srinivasan, Sivasubramanian
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2020
Elsevier
Subjects
Antivirals
Computational analysis
Docking
Drugs
Influenza A virus
Neuraminidase
Drugs
Docking
Computational analysis
Influenza A virus
Neuraminidase
Antivirals
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Abstract Influenza virus is an enveloped virus having segmented genome, coded by eight (negative-sense) RNA segments. The RNA segments are packed in a nucleocapsid protein. Neuraminidase (NA), an exosialidase, is the major antigen as well as vital virulence factor of the virus and is coded by the 6th segment of RNA. Eleven subtypes of NA are characterized for influenza A and the N1–N9 are divided into two phylogenic groups. NA is an active target for development of potent antivirals or Neuraminidase inhibitors (NAIs), which are reported to interact with multiple conserved residues in the active site of NA resulting in inhibition of virion release and prevention of viral spread to nearby cells. The current computational study focuses on docking of eleven different drug-like molecules including the known NAIs such as oseltamivir and zanamivir against crystal structures of NA of human Influenza A virus subtypes of both phylogenic groups. The docking results of this study indicated that zanamivir was the most active drug candidate against various NA subtypes followed by laninamivir. The study provides insights on interactions as well as cross-reactivity between lead compounds and NA proteins of various influenza subtypes. Observations on the efficacy of these NAIs assessed by the computational study have to be validated through in vitro and in vivo studies for successfully translating them as potential therapeutic agents to treat infection by various subtypes of influenza.
AbstractList Influenza virus is an enveloped virus having segmented genome, coded by eight (negative-sense) RNA segments. The RNA segments are packed in a nucleocapsid protein. Neuraminidase (NA), an exosialidase, is the major antigen as well as vital virulence factor of the virus and is coded by the 6th segment of RNA. Eleven subtypes of NA are characterized for influenza A and the N1–N9 are divided into two phylogenic groups. NA is an active target for development of potent antivirals or Neuraminidase inhibitors (NAIs), which are reported to interact with multiple conserved residues in the active site of NA resulting in inhibition of virion release and prevention of viral spread to nearby cells. The current computational study focuses on docking of eleven different drug-like molecules including the known NAIs such as oseltamivir and zanamivir against crystal structures of NA of human Influenza A virus subtypes of both phylogenic groups. The docking results of this study indicated that zanamivir was the most active drug candidate against various NA subtypes followed by laninamivir. The study provides insights on interactions as well as cross-reactivity between lead compounds and NA proteins of various influenza subtypes. Observations on the efficacy of these NAIs assessed by the computational study have to be validated through in vitro and in vivo studies for successfully translating them as potential therapeutic agents to treat infection by various subtypes of influenza.
Influenza virus is an enveloped virus having segmented genome, coded by eight (negative-sense) RNA segments. The RNA segments are packed in a nucleocapsid protein. Neuraminidase (NA), an exosialidase, is the major antigen as well as vital virulence factor of the virus and is coded by the 6th segment of RNA. Eleven subtypes of NA are characterized for influenza A and the N1–N9 are divided into two phylogenic groups. NA is an active target for development of potent antivirals or Neuraminidase inhibitors (NAIs), which are reported to interact with multiple conserved residues in the active site of NA resulting in inhibition of virion release and prevention of viral spread to nearby cells. The current computational study focuses on docking of eleven different drug-like molecules including the known NAIs such as oseltamivir and zanamivir against crystal structures of NA of human Influenza A virus subtypes of both phylogenic groups. The docking results of this study indicated that zanamivir was the most active drug candidate against various NA subtypes followed by laninamivir. The study provides insights on interactions as well as cross-reactivity between lead compounds and NA proteins of various influenza subtypes. Observations on the efficacy of these NAIs assessed by the computational study have to be validated through in vitro and in vivo studies for successfully translating them as potential therapeutic agents to treat infection by various subtypes of influenza. Keywords: Influenza A virus, Computational analysis, Docking, Neuraminidase, Antivirals, Drugs
ArticleNumber 100284
Author Devadasan, Velmurugan
Srinivasan, Sivasubramanian
Krishnasamy, Kaveri
Selvaraj, Gracy Fathima
Piramanayagam, Shanmugavel
Hassan, Sameer
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  givenname: Shanmugavel
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  fullname: Devadasan, Velmurugan
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Cites_doi 10.1021/jm800455g
10.1016/S1473-3099(11)70008-1
10.1007/s11434-011-4517-9
10.1038/303035a0
10.1038/nature05114
10.1371/journal.ppat.1002249
10.1371/journal.ppat.1003657
10.1128/JVI.03122-15
10.1073/pnas.1116200109
10.1107/S0108767307035623
10.1038/303041a0
10.1110/ps.41801
10.1177/0091270012440280
10.17221/6746-VETMED
10.1096/fj.08-119131
10.1002/rmv.352
10.3389/fmicb.2016.00450
10.1006/jmbi.1996.0897
10.1126/science.1222213
10.1107/S0907444904026460
10.1016/0022-2836(91)80068-6
10.3851/IMP1194
10.3389/fmicb.2019.00039
10.1093/infdis/jiq010
10.1128/AAC.49.11.4515-4520.2005
10.1111/j.1750-2659.2011.00304.x
10.1038/mi.2017.16
10.1371/journal.ppat.1000786
10.1093/nar/29.1.221
10.1128/AAC.00731-09
10.1086/514178
10.1007/s11427-010-4010-8
10.1002/cmdc.201200155
10.1002/prot.340140302
10.1016/S0021-9258(18)68802-7
10.1002/pro.5560040606
10.1111/irv.12047
10.1093/protein/8.2.127
10.1146/annurev.biochem.78.082207.084029
10.1093/bioinformatics/btl158
10.1038/msb.2011.75
10.1093/molbev/msy096
10.1016/j.virol.2010.04.030
10.1016/j.chom.2015.02.012
10.1021/jm00017a005
10.2147/DDDT.S176220
10.1186/1758-2946-1-12
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Keywords Drugs
Docking
Computational analysis
Influenza A virus
Neuraminidase
Antivirals
Language English
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References Vavricka, Li, Wu, Qi, Wang (bib30) 2011; 7
WHO (bib2) 2018
Mishin, Hayden, Gubareva (bib43) 2005; 49
Krissinel, Henrick (bib36) 2004; 60
Vavricka, Liu, Li, Shi, Wu, Sun (bib6) 2011; 56
Smith, Colman, Von Itzstein, Danylec, Varghese (bib31) 2001; 10
Luo, Air, Brouillette (bib26) 1997; 176
Colman (bib21) 2009; 78
Cole, Nissink, Taylor (bib41) 2005
Sun, Shi, Zhang, Li, Liu, Vavricka (bib7) 2010; 53
Pizzorno, Bouhy, Abed, Boivin (bib42) 2011; 203
Houser, Subbarao (bib13) 2015; 17
Alame, Massaad, Zaraket (bib29) 2016; 7
Varghese, McKimm-Breschkin, Caldwell, Kortt, Colman (bib23) 1992; 14
Bossart, Babu, Cook, Air, Laver (bib17) 1988; 263
Eyer, Hruska (bib47) 2013; 58
Tong, Zhu, Li, Shi, Zhang, Bourgeois (bib15) 2013; 9
Sievers, Wilm, Dineen, Gibson, Karplus, Li (bib33) 2011; 7
Li, Godzik, Cd-hit (bib34) 2006; 22
Jones, Willett, Glen, Leach, Taylor (bib40) 1997
McAuley, Gilbertson, Trifkovic, Brown, McKimm-Breschkin (bib19) 2019; 10
Singh, Jedrzejas, Air, Luo, Laver, Brouillette (bib25) 1995; 38
Berman (bib27) 2008; 64
Kamali, Holodniy (bib50) 2013; 6
McKimm-Breschkin (bib28) 2012; 7
Gessner, Shindo, Briand (bib1) 2011; 11
Varghese, Colman (bib22) 1991; 221
Wagner, Matrosovich, Klenk (bib4) 2002; 12
Ferguson, Olivier, Genova, Epperson, Smith, Schneider (bib3) 2016; 90
An, Lee, Law, Yang, Poon, Lau (bib20) 2009; 52
Moules, Ferraris, Terrier, Giudice, Yver, Rolland (bib12) 2010; 404
Chairat, Tarning, White, Lindegardh (bib48) 2013; 53
Feng, Ye, Li, Zhang, Wang, Zhao (bib49) 2012; 7
Air (bib8) 2012; 6
Kumar, Stecher, Li, Knyaz, Tamura, MEGA (bib35) 2018; 35
Varghese, Laver, Colman (bib11) 1983; 303
Kesimer, Scull, Brighton, Demaria, Burns, O'Neal (bib9) 2009; 23
Laskowski (bib38) 2001; 29
Tong, Li, Rivailler, Conrardy, Castillo, Chen (bib14) 2012; 109
Wallace, Laskowski, Thornton (bib37) 1995; 8
Jagger, Wise, Kash, Walters, Wills, Xiao (bib5) 2012; 337
Tashiro, McKimm-Breschkin, Saito, Klimov, Macken, Zambon (bib46) 2009; 14
Koyama, Takahashi, Oitate, Nakai, Takakusa, Miura (bib44) 2009; 53
McAuley, Corcilius, Tan, Payne, McGuckin, Brown (bib10) 2017; 10
Colman, Varghese, Laver (bib18) 1983; 303
Russell, Haire, Stevens, Collins, Lin, Blackburn (bib16) 2006; 443
Varghese, Epa, Colman (bib24) 1995; 4
Kiso, Kubo, Ozawa, Le, Nidom, Yamashita (bib45) 2010; 6
Rahman, Bashton, Holliday, Schrader, Thornton (bib39) 2009; 1
Glanz, Myasoedova, Grechko, Orekhov (bib32) 2018
Ferguson (10.1016/j.imu.2019.100284_bib3) 2016; 90
Alame (10.1016/j.imu.2019.100284_bib29) 2016; 7
Chairat (10.1016/j.imu.2019.100284_bib48) 2013; 53
Kamali (10.1016/j.imu.2019.100284_bib50) 2013; 6
Koyama (10.1016/j.imu.2019.100284_bib44) 2009; 53
McKimm-Breschkin (10.1016/j.imu.2019.100284_bib28) 2012; 7
Russell (10.1016/j.imu.2019.100284_bib16) 2006; 443
Colman (10.1016/j.imu.2019.100284_bib18) 1983; 303
Jones (10.1016/j.imu.2019.100284_bib40) 1997
Vavricka (10.1016/j.imu.2019.100284_bib30) 2011; 7
Wallace (10.1016/j.imu.2019.100284_bib37) 1995; 8
Mishin (10.1016/j.imu.2019.100284_bib43) 2005; 49
Laskowski (10.1016/j.imu.2019.100284_bib38) 2001; 29
WHO (10.1016/j.imu.2019.100284_bib2) 2018
Kumar (10.1016/j.imu.2019.100284_bib35) 2018; 35
Eyer (10.1016/j.imu.2019.100284_bib47) 2013; 58
Li (10.1016/j.imu.2019.100284_bib34) 2006; 22
Bossart (10.1016/j.imu.2019.100284_bib17) 1988; 263
Varghese (10.1016/j.imu.2019.100284_bib11) 1983; 303
Vavricka (10.1016/j.imu.2019.100284_bib6) 2011; 56
Moules (10.1016/j.imu.2019.100284_bib12) 2010; 404
McAuley (10.1016/j.imu.2019.100284_bib19) 2019; 10
Houser (10.1016/j.imu.2019.100284_bib13) 2015; 17
Tashiro (10.1016/j.imu.2019.100284_bib46) 2009; 14
Gessner (10.1016/j.imu.2019.100284_bib1) 2011; 11
Smith (10.1016/j.imu.2019.100284_bib31) 2001; 10
An (10.1016/j.imu.2019.100284_bib20) 2009; 52
Varghese (10.1016/j.imu.2019.100284_bib24) 1995; 4
Kesimer (10.1016/j.imu.2019.100284_bib9) 2009; 23
Tong (10.1016/j.imu.2019.100284_bib15) 2013; 9
McAuley (10.1016/j.imu.2019.100284_bib10) 2017; 10
Glanz (10.1016/j.imu.2019.100284_bib32) 2018
Kiso (10.1016/j.imu.2019.100284_bib45) 2010; 6
Varghese (10.1016/j.imu.2019.100284_bib23) 1992; 14
Tong (10.1016/j.imu.2019.100284_bib14) 2012; 109
Singh (10.1016/j.imu.2019.100284_bib25) 1995; 38
Air (10.1016/j.imu.2019.100284_bib8) 2012; 6
Varghese (10.1016/j.imu.2019.100284_bib22) 1991; 221
Luo (10.1016/j.imu.2019.100284_bib26) 1997; 176
Colman (10.1016/j.imu.2019.100284_bib21) 2009; 78
Sun (10.1016/j.imu.2019.100284_bib7) 2010; 53
Berman (10.1016/j.imu.2019.100284_bib27) 2008; 64
Rahman (10.1016/j.imu.2019.100284_bib39) 2009; 1
Jagger (10.1016/j.imu.2019.100284_bib5) 2012; 337
Cole (10.1016/j.imu.2019.100284_bib41) 2005
Pizzorno (10.1016/j.imu.2019.100284_bib42) 2011; 203
Feng (10.1016/j.imu.2019.100284_bib49) 2012; 7
Krissinel (10.1016/j.imu.2019.100284_bib36) 2004; 60
Sievers (10.1016/j.imu.2019.100284_bib33) 2011; 7
Wagner (10.1016/j.imu.2019.100284_bib4) 2002; 12
References_xml – volume: 263
  start-page: 6421
  year: 1988
  end-page: 6423
  ident: bib17
  article-title: Crystallization and preliminary X-ray analyses of two neuraminidases from influenza B virus strains B/Hong Kong/8/73 and B/Lee/40
  publication-title: J Biol Chem
  contributor:
    fullname: Laver
– volume: 53
  start-page: 4845
  year: 2009
  end-page: 4851
  ident: bib44
  article-title: CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favourable long-retention profile in the mouse respiratory tract
  publication-title: Antimicrob Agents Chemother
  contributor:
    fullname: Miura
– year: 2018
  ident: bib2
  article-title: Influenza (seasonal) fact sheet
  contributor:
    fullname: WHO
– volume: 10
  start-page: 1581
  year: 2017
  end-page: 1593
  ident: bib10
  article-title: The cell surface mucin MUC1 limits the severity of influenza A virus infection
  publication-title: Mucosal Immunol
  contributor:
    fullname: Brown
– volume: 4
  start-page: 1081
  year: 1995
  end-page: 1087
  ident: bib24
  article-title: Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase
  publication-title: Protein Sci
  contributor:
    fullname: Colman
– volume: 49
  start-page: 4515
  year: 2005
  end-page: 4520
  ident: bib43
  article-title: Susceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors
  publication-title: Antimicrob Agents Chemother
  contributor:
    fullname: Gubareva
– volume: 38
  start-page: 3217
  year: 1995
  end-page: 3225
  ident: bib25
  article-title: Structure based inhibitors of Influenza virus sialidase. A benzoic acid lead with novel interaction
  publication-title: J Med Chem
  contributor:
    fullname: Brouillette
– volume: 7
  start-page: 450
  year: 2016
  ident: bib29
  article-title: Peramivir: a novel intravenous neuraminidase inhibitor for treatment of acute influenza infections
  publication-title: Front Microbiol
  contributor:
    fullname: Zaraket
– year: 2005
  ident: bib41
  publication-title: Protein-ligand docking and virtual screening with GOLD in virtual screening in drug discovery
  contributor:
    fullname: Taylor
– volume: 22
  start-page: 1658
  year: 2006
  end-page: 1659
  ident: bib34
  article-title: A fast program for clustering and comparing large sets of protein or nucleotide sequences
  publication-title: Bioinformatics
  contributor:
    fullname: Cd-hit
– volume: 23
  start-page: 1858
  year: 2009
  end-page: 1868
  ident: bib9
  article-title: Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense
  publication-title: FASEB J
  contributor:
    fullname: O'Neal
– volume: 303
  start-page: 41
  year: 1983
  end-page: 44
  ident: bib18
  article-title: Structure of the catalytic and antigenic sites in influenza virus neuraminidase
  publication-title: Nature
  contributor:
    fullname: Laver
– volume: 7
  start-page: 539
  year: 2011
  ident: bib33
  article-title: Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
  publication-title: Mol Syst Biol
  contributor:
    fullname: Li
– volume: 9
  year: 2013
  ident: bib15
  article-title: New world bats harbor diverse influenza A viruses
  publication-title: PLoS Pathog
  contributor:
    fullname: Bourgeois
– volume: 56
  start-page: 1747
  year: 2011
  end-page: 1752
  ident: bib6
  article-title: Special features of the 2009 pandemic swine-origin influenza AH1N1 hemagglutinin and neuraminidase
  publication-title: Chin Sci Bull
  contributor:
    fullname: Sun
– volume: 109
  start-page: 4269
  year: 2012
  end-page: 4274
  ident: bib14
  article-title: A distinct lineage of influenza a virus from bats
  publication-title: Proc Natl Acad Sci U S A
  contributor:
    fullname: Chen
– volume: 7
  year: 2011
  ident: bib30
  article-title: Structural and functional analysis of Laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA Inhibition
  publication-title: PLoS Pathog
  contributor:
    fullname: Wang
– volume: 35
  start-page: 1547
  year: 2018
  end-page: 1549
  ident: bib35
  article-title: Molecular evolutionary genetics analysis across computing platforms
  publication-title: Mol Biol Evol
  contributor:
    fullname: MEGA
– start-page: 3431
  year: 2018
  end-page: 3437
  ident: bib32
  article-title: Inhibition of sialidase activity as a therapeutic approach
  publication-title: Drug Des Dev Ther
  contributor:
    fullname: Orekhov
– volume: 78
  start-page: 95
  year: 2009
  end-page: 118
  ident: bib21
  article-title: New antivirals and drug resistance
  publication-title: Annu Rev Biochem
  contributor:
    fullname: Colman
– volume: 53
  start-page: 119
  year: 2013
  end-page: 139
  ident: bib48
  article-title: Pharmacokinetic properties of anti- influenza neuraminidase inhibitors
  publication-title: J Clin Pharmacol
  contributor:
    fullname: Lindegardh
– volume: 52
  start-page: 2667
  year: 2009
  end-page: 2672
  ident: bib20
  article-title: A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase
  publication-title: J Med Chem
  contributor:
    fullname: Lau
– volume: 17
  start-page: 295
  year: 2015
  end-page: 300
  ident: bib13
  article-title: Influenza vaccines: challenges and solutions
  publication-title: Cell Host Microbe
  contributor:
    fullname: Subbarao
– volume: 6
  start-page: 245
  year: 2012
  end-page: 256
  ident: bib8
  article-title: Influenza neuraminidase
  publication-title: Influenza Other Respir Viruses
  contributor:
    fullname: Air
– volume: 303
  start-page: 35
  year: 1983
  end-page: 40
  ident: bib11
  article-title: Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A
  publication-title: Nature
  contributor:
    fullname: Colman
– volume: 404
  start-page: 215
  year: 2010
  end-page: 224
  ident: bib12
  article-title: In vitro characterization of naturally occurring influenza H3NA-viruses lacking the NA gene segment: toward a new mechanism of viral resistance?
  publication-title: Virology
  contributor:
    fullname: Rolland
– volume: 203
  start-page: 25
  year: 2011
  end-page: 31
  ident: bib42
  article-title: Generation and characterization of recombinant pandemic influenza A (H1N1) viruses resistant to neuraminidase inhibitors
  publication-title: J Infect Dis
  contributor:
    fullname: Boivin
– volume: 176
  start-page: S62
  year: 1997
  end-page: S65
  ident: bib26
  article-title: Design of aromatic inhibitors of influenza virus neuraminidase
  publication-title: J Infect Dis
  contributor:
    fullname: Brouillette
– volume: 53
  start-page: 633
  year: 2010
  end-page: 642
  ident: bib7
  article-title: silico characterization of the functional and structural modules of the hemagglutinin protein from the swine-origin influenza virus A (H1N1)-2009
  publication-title: Sci China Life Sci
  contributor:
    fullname: Vavricka
– volume: 64
  start-page: 88
  year: 2008
  end-page: 95
  ident: bib27
  article-title: The protein Data Bank: a historical perspective
  publication-title: Acta Crystallogr A Found Crystallogr
  contributor:
    fullname: Berman
– start-page: 727
  year: 1997
  end-page: 748
  ident: bib40
  article-title: Development and validation of a genetic algorithm for flexible docking
  publication-title: J Mol Biol
  contributor:
    fullname: Taylor
– volume: 443
  start-page: 45
  year: 2006
  end-page: 49
  ident: bib16
  article-title: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design
  publication-title: Nature
  contributor:
    fullname: Blackburn
– volume: 7
  start-page: 25
  year: 2012
  end-page: 36
  ident: bib28
  article-title: Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance
  publication-title: Influenza Other Respir Viruses
  contributor:
    fullname: McKimm-Breschkin
– volume: 6
  year: 2010
  ident: bib45
  article-title: Efficacy of the new neuraminidase inhibitor CS-8958 against H5N1 influenza viruses
  publication-title: PLoS Pathog
  contributor:
    fullname: Yamashita
– volume: 12
  start-page: 159
  year: 2002
  end-page: 166
  ident: bib4
  article-title: Functional balance between haemagglutinin and neuraminidase in influenza virus infections
  publication-title: Rev Med Virol
  contributor:
    fullname: Klenk
– volume: 337
  start-page: 199
  year: 2012
  end-page: 204
  ident: bib5
  article-title: An overlapping protein-coding region in influenza A virus segment 3 modulates the host response
  publication-title: Science
  contributor:
    fullname: Xiao
– volume: 60
  start-page: 2256
  year: 2004
  end-page: 2268
  ident: bib36
  article-title: Secondary-structure matching (SSM), a new tool for fast Protein structure alignment in three dimensions
  publication-title: Acta Crystallogr D Biol Crystallogr
  contributor:
    fullname: Henrick
– volume: 1
  start-page: 12
  year: 2009
  ident: bib39
  article-title: Software: small molecule Subgraph detector (SMSD) toolkit
  publication-title: J Cheminf
  contributor:
    fullname: Thornton
– volume: 29
  start-page: 221
  year: 2001
  end-page: 222
  ident: bib38
  article-title: PDBsum: summaries and analyses of PDB structures
  publication-title: Nucleic Acids Res
  contributor:
    fullname: Laskowski
– volume: 90
  start-page: 5636
  year: 2016
  end-page: 5642
  ident: bib3
  article-title: Pathogenesis of influenza D virus in cattle
  publication-title: J Virol
  contributor:
    fullname: Schneider
– volume: 7
  start-page: 1527
  year: 2012
  end-page: 1536
  ident: bib49
  article-title: Recent advances in neuraminidase inhibitor development as anti-influenza drugs
  publication-title: ChemMedChem
  contributor:
    fullname: Zhao
– volume: 221
  start-page: 473
  year: 1991
  end-page: 486
  ident: bib22
  article-title: Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution
  publication-title: J Mol Biol
  contributor:
    fullname: Colman
– volume: 11
  start-page: 223
  year: 2011
  end-page: 235
  ident: bib1
  article-title: Seasonal influenza epidemiology in sub-Saharan Africa: a systematic review
  publication-title: Lancet Infect Dis
  contributor:
    fullname: Briand
– volume: 8
  start-page: 127
  year: 1995
  end-page: 134
  ident: bib37
  article-title: LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions
  publication-title: Protein Eng
  contributor:
    fullname: Thornton
– volume: 58
  start-page: 113
  year: 2013
  end-page: 185
  ident: bib47
  article-title: Antiviral agents targeting the influenza virus: a review and publication analysis
  publication-title: Vet Med
  contributor:
    fullname: Hruska
– volume: 10
  start-page: 39
  year: 2019
  ident: bib19
  article-title: Influenza virus neuraminidase structure and functions
  publication-title: Front Microbiol
  contributor:
    fullname: McKimm-Breschkin
– volume: 14
  start-page: 327
  year: 1992
  end-page: 332
  ident: bib23
  article-title: The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor
  publication-title: Proteins
  contributor:
    fullname: Colman
– volume: 6
  start-page: 187
  year: 2013
  end-page: 198
  ident: bib50
  article-title: Influenza treatment and prophylaxis with neuraminidase inhibitors: a review
  publication-title: Infect Drug Resist
  contributor:
    fullname: Holodniy
– volume: 10
  start-page: 689
  year: 2001
  end-page: 696
  ident: bib31
  article-title: Analysis of inhibitor binding in influenza virus neuraminidase
  publication-title: Protein Sci
  contributor:
    fullname: Varghese
– volume: 14
  start-page: 751
  year: 2009
  end-page: 761
  ident: bib46
  article-title: Surveillance for neuraminidase-inhibitor-resistant influenza viruses in Japan, 1996–2007
  publication-title: Antivir Ther
  contributor:
    fullname: Zambon
– volume: 52
  start-page: 2667
  year: 2009
  ident: 10.1016/j.imu.2019.100284_bib20
  article-title: A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase
  publication-title: J Med Chem
  doi: 10.1021/jm800455g
  contributor:
    fullname: An
– volume: 11
  start-page: 223
  year: 2011
  ident: 10.1016/j.imu.2019.100284_bib1
  article-title: Seasonal influenza epidemiology in sub-Saharan Africa: a systematic review
  publication-title: Lancet Infect Dis
  doi: 10.1016/S1473-3099(11)70008-1
  contributor:
    fullname: Gessner
– volume: 56
  start-page: 1747
  year: 2011
  ident: 10.1016/j.imu.2019.100284_bib6
  article-title: Special features of the 2009 pandemic swine-origin influenza AH1N1 hemagglutinin and neuraminidase
  publication-title: Chin Sci Bull
  doi: 10.1007/s11434-011-4517-9
  contributor:
    fullname: Vavricka
– volume: 303
  start-page: 35
  year: 1983
  ident: 10.1016/j.imu.2019.100284_bib11
  article-title: Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A0 resolution
  publication-title: Nature
  doi: 10.1038/303035a0
  contributor:
    fullname: Varghese
– volume: 443
  start-page: 45
  year: 2006
  ident: 10.1016/j.imu.2019.100284_bib16
  article-title: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design
  publication-title: Nature
  doi: 10.1038/nature05114
  contributor:
    fullname: Russell
– volume: 7
  year: 2011
  ident: 10.1016/j.imu.2019.100284_bib30
  article-title: Structural and functional analysis of Laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA Inhibition
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1002249
  contributor:
    fullname: Vavricka
– year: 2018
  ident: 10.1016/j.imu.2019.100284_bib2
  contributor:
    fullname: WHO
– volume: 9
  year: 2013
  ident: 10.1016/j.imu.2019.100284_bib15
  article-title: New world bats harbor diverse influenza A viruses
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1003657
  contributor:
    fullname: Tong
– volume: 90
  start-page: 5636
  year: 2016
  ident: 10.1016/j.imu.2019.100284_bib3
  article-title: Pathogenesis of influenza D virus in cattle
  publication-title: J Virol
  doi: 10.1128/JVI.03122-15
  contributor:
    fullname: Ferguson
– volume: 109
  start-page: 4269
  year: 2012
  ident: 10.1016/j.imu.2019.100284_bib14
  article-title: A distinct lineage of influenza a virus from bats
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1116200109
  contributor:
    fullname: Tong
– volume: 64
  start-page: 88
  year: 2008
  ident: 10.1016/j.imu.2019.100284_bib27
  article-title: The protein Data Bank: a historical perspective
  publication-title: Acta Crystallogr A Found Crystallogr
  doi: 10.1107/S0108767307035623
  contributor:
    fullname: Berman
– volume: 303
  start-page: 41
  year: 1983
  ident: 10.1016/j.imu.2019.100284_bib18
  article-title: Structure of the catalytic and antigenic sites in influenza virus neuraminidase
  publication-title: Nature
  doi: 10.1038/303041a0
  contributor:
    fullname: Colman
– year: 2005
  ident: 10.1016/j.imu.2019.100284_bib41
  contributor:
    fullname: Cole
– volume: 10
  start-page: 689
  year: 2001
  ident: 10.1016/j.imu.2019.100284_bib31
  article-title: Analysis of inhibitor binding in influenza virus neuraminidase
  publication-title: Protein Sci
  doi: 10.1110/ps.41801
  contributor:
    fullname: Smith
– volume: 53
  start-page: 119
  year: 2013
  ident: 10.1016/j.imu.2019.100284_bib48
  article-title: Pharmacokinetic properties of anti- influenza neuraminidase inhibitors
  publication-title: J Clin Pharmacol
  doi: 10.1177/0091270012440280
  contributor:
    fullname: Chairat
– volume: 6
  start-page: 187
  year: 2013
  ident: 10.1016/j.imu.2019.100284_bib50
  article-title: Influenza treatment and prophylaxis with neuraminidase inhibitors: a review
  publication-title: Infect Drug Resist
  contributor:
    fullname: Kamali
– volume: 58
  start-page: 113
  year: 2013
  ident: 10.1016/j.imu.2019.100284_bib47
  article-title: Antiviral agents targeting the influenza virus: a review and publication analysis
  publication-title: Vet Med
  doi: 10.17221/6746-VETMED
  contributor:
    fullname: Eyer
– volume: 23
  start-page: 1858
  year: 2009
  ident: 10.1016/j.imu.2019.100284_bib9
  article-title: Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense
  publication-title: FASEB J
  doi: 10.1096/fj.08-119131
  contributor:
    fullname: Kesimer
– volume: 12
  start-page: 159
  year: 2002
  ident: 10.1016/j.imu.2019.100284_bib4
  article-title: Functional balance between haemagglutinin and neuraminidase in influenza virus infections
  publication-title: Rev Med Virol
  doi: 10.1002/rmv.352
  contributor:
    fullname: Wagner
– volume: 7
  start-page: 450
  year: 2016
  ident: 10.1016/j.imu.2019.100284_bib29
  article-title: Peramivir: a novel intravenous neuraminidase inhibitor for treatment of acute influenza infections
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2016.00450
  contributor:
    fullname: Alame
– start-page: 727
  year: 1997
  ident: 10.1016/j.imu.2019.100284_bib40
  article-title: Development and validation of a genetic algorithm for flexible docking
  publication-title: J Mol Biol
  doi: 10.1006/jmbi.1996.0897
  contributor:
    fullname: Jones
– volume: 337
  start-page: 199
  year: 2012
  ident: 10.1016/j.imu.2019.100284_bib5
  article-title: An overlapping protein-coding region in influenza A virus segment 3 modulates the host response
  publication-title: Science
  doi: 10.1126/science.1222213
  contributor:
    fullname: Jagger
– volume: 60
  start-page: 2256
  year: 2004
  ident: 10.1016/j.imu.2019.100284_bib36
  article-title: Secondary-structure matching (SSM), a new tool for fast Protein structure alignment in three dimensions
  publication-title: Acta Crystallogr D Biol Crystallogr
  doi: 10.1107/S0907444904026460
  contributor:
    fullname: Krissinel
– volume: 221
  start-page: 473
  year: 1991
  ident: 10.1016/j.imu.2019.100284_bib22
  article-title: Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution
  publication-title: J Mol Biol
  doi: 10.1016/0022-2836(91)80068-6
  contributor:
    fullname: Varghese
– volume: 14
  start-page: 751
  year: 2009
  ident: 10.1016/j.imu.2019.100284_bib46
  article-title: Surveillance for neuraminidase-inhibitor-resistant influenza viruses in Japan, 1996–2007
  publication-title: Antivir Ther
  doi: 10.3851/IMP1194
  contributor:
    fullname: Tashiro
– volume: 10
  start-page: 39
  year: 2019
  ident: 10.1016/j.imu.2019.100284_bib19
  article-title: Influenza virus neuraminidase structure and functions
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2019.00039
  contributor:
    fullname: McAuley
– volume: 203
  start-page: 25
  year: 2011
  ident: 10.1016/j.imu.2019.100284_bib42
  article-title: Generation and characterization of recombinant pandemic influenza A (H1N1) viruses resistant to neuraminidase inhibitors
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiq010
  contributor:
    fullname: Pizzorno
– volume: 49
  start-page: 4515
  year: 2005
  ident: 10.1016/j.imu.2019.100284_bib43
  article-title: Susceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.49.11.4515-4520.2005
  contributor:
    fullname: Mishin
– volume: 6
  start-page: 245
  year: 2012
  ident: 10.1016/j.imu.2019.100284_bib8
  article-title: Influenza neuraminidase
  publication-title: Influenza Other Respir Viruses
  doi: 10.1111/j.1750-2659.2011.00304.x
  contributor:
    fullname: Air
– volume: 10
  start-page: 1581
  year: 2017
  ident: 10.1016/j.imu.2019.100284_bib10
  article-title: The cell surface mucin MUC1 limits the severity of influenza A virus infection
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2017.16
  contributor:
    fullname: McAuley
– volume: 6
  year: 2010
  ident: 10.1016/j.imu.2019.100284_bib45
  article-title: Efficacy of the new neuraminidase inhibitor CS-8958 against H5N1 influenza viruses
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1000786
  contributor:
    fullname: Kiso
– volume: 29
  start-page: 221
  year: 2001
  ident: 10.1016/j.imu.2019.100284_bib38
  article-title: PDBsum: summaries and analyses of PDB structures
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/29.1.221
  contributor:
    fullname: Laskowski
– volume: 53
  start-page: 4845
  year: 2009
  ident: 10.1016/j.imu.2019.100284_bib44
  article-title: CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favourable long-retention profile in the mouse respiratory tract
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.00731-09
  contributor:
    fullname: Koyama
– volume: 176
  start-page: S62
  year: 1997
  ident: 10.1016/j.imu.2019.100284_bib26
  article-title: Design of aromatic inhibitors of influenza virus neuraminidase
  publication-title: J Infect Dis
  doi: 10.1086/514178
  contributor:
    fullname: Luo
– volume: 53
  start-page: 633
  year: 2010
  ident: 10.1016/j.imu.2019.100284_bib7
  article-title: In silico characterization of the functional and structural modules of the hemagglutinin protein from the swine-origin influenza virus A (H1N1)-2009
  publication-title: Sci China Life Sci
  doi: 10.1007/s11427-010-4010-8
  contributor:
    fullname: Sun
– volume: 7
  start-page: 1527
  year: 2012
  ident: 10.1016/j.imu.2019.100284_bib49
  article-title: Recent advances in neuraminidase inhibitor development as anti-influenza drugs
  publication-title: ChemMedChem
  doi: 10.1002/cmdc.201200155
  contributor:
    fullname: Feng
– volume: 14
  start-page: 327
  year: 1992
  ident: 10.1016/j.imu.2019.100284_bib23
  article-title: The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor
  publication-title: Proteins
  doi: 10.1002/prot.340140302
  contributor:
    fullname: Varghese
– volume: 263
  start-page: 6421
  year: 1988
  ident: 10.1016/j.imu.2019.100284_bib17
  article-title: Crystallization and preliminary X-ray analyses of two neuraminidases from influenza B virus strains B/Hong Kong/8/73 and B/Lee/40
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)68802-7
  contributor:
    fullname: Bossart
– volume: 4
  start-page: 1081
  year: 1995
  ident: 10.1016/j.imu.2019.100284_bib24
  article-title: Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase
  publication-title: Protein Sci
  doi: 10.1002/pro.5560040606
  contributor:
    fullname: Varghese
– volume: 7
  start-page: 25
  year: 2012
  ident: 10.1016/j.imu.2019.100284_bib28
  article-title: Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance
  publication-title: Influenza Other Respir Viruses
  doi: 10.1111/irv.12047
  contributor:
    fullname: McKimm-Breschkin
– volume: 8
  start-page: 127
  year: 1995
  ident: 10.1016/j.imu.2019.100284_bib37
  article-title: LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions
  publication-title: Protein Eng
  doi: 10.1093/protein/8.2.127
  contributor:
    fullname: Wallace
– volume: 78
  start-page: 95
  year: 2009
  ident: 10.1016/j.imu.2019.100284_bib21
  article-title: New antivirals and drug resistance
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev.biochem.78.082207.084029
  contributor:
    fullname: Colman
– volume: 22
  start-page: 1658
  year: 2006
  ident: 10.1016/j.imu.2019.100284_bib34
  article-title: A fast program for clustering and comparing large sets of protein or nucleotide sequences
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btl158
  contributor:
    fullname: Li
– volume: 7
  start-page: 539
  year: 2011
  ident: 10.1016/j.imu.2019.100284_bib33
  article-title: Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
  publication-title: Mol Syst Biol
  doi: 10.1038/msb.2011.75
  contributor:
    fullname: Sievers
– volume: 35
  start-page: 1547
  year: 2018
  ident: 10.1016/j.imu.2019.100284_bib35
  article-title: Molecular evolutionary genetics analysis across computing platforms
  publication-title: Mol Biol Evol
  doi: 10.1093/molbev/msy096
  contributor:
    fullname: Kumar
– volume: 404
  start-page: 215
  year: 2010
  ident: 10.1016/j.imu.2019.100284_bib12
  article-title: In vitro characterization of naturally occurring influenza H3NA-viruses lacking the NA gene segment: toward a new mechanism of viral resistance?
  publication-title: Virology
  doi: 10.1016/j.virol.2010.04.030
  contributor:
    fullname: Moules
– volume: 17
  start-page: 295
  year: 2015
  ident: 10.1016/j.imu.2019.100284_bib13
  article-title: Influenza vaccines: challenges and solutions
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2015.02.012
  contributor:
    fullname: Houser
– volume: 38
  start-page: 3217
  year: 1995
  ident: 10.1016/j.imu.2019.100284_bib25
  article-title: Structure based inhibitors of Influenza virus sialidase. A benzoic acid lead with novel interaction
  publication-title: J Med Chem
  doi: 10.1021/jm00017a005
  contributor:
    fullname: Singh
– start-page: 3431
  year: 2018
  ident: 10.1016/j.imu.2019.100284_bib32
  article-title: Inhibition of sialidase activity as a therapeutic approach
  publication-title: Drug Des Dev Ther
  doi: 10.2147/DDDT.S176220
  contributor:
    fullname: Glanz
– volume: 1
  start-page: 12
  year: 2009
  ident: 10.1016/j.imu.2019.100284_bib39
  article-title: Software: small molecule Subgraph detector (SMSD) toolkit
  publication-title: J Cheminf
  doi: 10.1186/1758-2946-1-12
  contributor:
    fullname: Rahman
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Snippet Influenza virus is an enveloped virus having segmented genome, coded by eight (negative-sense) RNA segments. The RNA segments are packed in a nucleocapsid...
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SubjectTerms Antivirals
Computational analysis
Docking
Drugs
Influenza A virus
Neuraminidase
Title Computational analysis of drug like candidates against Neuraminidase of Human Influenza A virus subtypes
URI https://dx.doi.org/10.1016/j.imu.2019.100284
https://doaj.org/article/21c935ec965843e7ac22a9bd5515799a
Volume 18
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