Metabolomics and correlation network analysis of follicular fluid reveals associations between l‐tryptophan, l‐tyrosine and polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in women of reproductive age. Some studies have investigated metabolic alterations in plasma and follicular fluid from PCOS patients, but they did not control for obesity or insulin resistance (IR); additionally, correlation ana...
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| Published in | Biomedical chromatography Vol. 35; no. 3; pp. e4993 - n/a |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.03.2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0269-3879 1099-0801 1099-0801 |
| DOI | 10.1002/bmc.4993 |
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| Abstract | Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in women of reproductive age. Some studies have investigated metabolic alterations in plasma and follicular fluid from PCOS patients, but they did not control for obesity or insulin resistance (IR); additionally, correlation analysis of metabolites is sparse. Accordingly, in this study, we aimed to examine metabolic differences owing to the pathogenesis of PCOS, identify the hub metabolites and investigate its associations with androgens. We applied GC–MS platform coupled with a correlation network approach to analyze follicular fluid samples from 32 PCOS patients without obesity and IR and 31 healthy women. Thirty significantly altered metabolites in PCOS patients were enriched in amino acid metabolism. l‐Phenylalanine, l‐tryptophan, pyroglutamic acid, l‐tyrosine, l‐leucine and l‐valine were screened as hub metabolites in metabolic correlation network. Among them, increased l‐tryptophan and l‐tyrosine were altered hub metabolites, and they had a more significant impact on the metabolic change of PCOS. In addition, l‐tryptophan and l‐tyrosine were significantly positively associated with serum androgens levels in the PCOS. Our results suggest that disorders of amino acid metabolism, especially tryptophan and tyrosine metabolism, might play an important role in the development of PCOS in predisposed women without obesity and IR. |
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| AbstractList | Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in women of reproductive age. Some studies have investigated metabolic alterations in plasma and follicular fluid from PCOS patients, but they did not control for obesity or insulin resistance (IR); additionally, correlation analysis of metabolites is sparse. Accordingly, in this study, we aimed to examine metabolic differences owing to the pathogenesis of PCOS, identify the hub metabolites and investigate its associations with androgens. We applied GC-MS platform coupled with a correlation network approach to analyze follicular fluid samples from 32 PCOS patients without obesity and IR and 31 healthy women. Thirty significantly altered metabolites in PCOS patients were enriched in amino acid metabolism. l-Phenylalanine, l-tryptophan, pyroglutamic acid, l-tyrosine, l-leucine and l-valine were screened as hub metabolites in metabolic correlation network. Among them, increased l-tryptophan and l-tyrosine were altered hub metabolites, and they had a more significant impact on the metabolic change of PCOS. In addition, l-tryptophan and l-tyrosine were significantly positively associated with serum androgens levels in the PCOS. Our results suggest that disorders of amino acid metabolism, especially tryptophan and tyrosine metabolism, might play an important role in the development of PCOS in predisposed women without obesity and IR.Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in women of reproductive age. Some studies have investigated metabolic alterations in plasma and follicular fluid from PCOS patients, but they did not control for obesity or insulin resistance (IR); additionally, correlation analysis of metabolites is sparse. Accordingly, in this study, we aimed to examine metabolic differences owing to the pathogenesis of PCOS, identify the hub metabolites and investigate its associations with androgens. We applied GC-MS platform coupled with a correlation network approach to analyze follicular fluid samples from 32 PCOS patients without obesity and IR and 31 healthy women. Thirty significantly altered metabolites in PCOS patients were enriched in amino acid metabolism. l-Phenylalanine, l-tryptophan, pyroglutamic acid, l-tyrosine, l-leucine and l-valine were screened as hub metabolites in metabolic correlation network. Among them, increased l-tryptophan and l-tyrosine were altered hub metabolites, and they had a more significant impact on the metabolic change of PCOS. In addition, l-tryptophan and l-tyrosine were significantly positively associated with serum androgens levels in the PCOS. Our results suggest that disorders of amino acid metabolism, especially tryptophan and tyrosine metabolism, might play an important role in the development of PCOS in predisposed women without obesity and IR. Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in women of reproductive age. Some studies have investigated metabolic alterations in plasma and follicular fluid from PCOS patients, but they did not control for obesity or insulin resistance (IR); additionally, correlation analysis of metabolites is sparse. Accordingly, in this study, we aimed to examine metabolic differences owing to the pathogenesis of PCOS, identify the hub metabolites and investigate its associations with androgens. We applied GC–MS platform coupled with a correlation network approach to analyze follicular fluid samples from 32 PCOS patients without obesity and IR and 31 healthy women. Thirty significantly altered metabolites in PCOS patients were enriched in amino acid metabolism. l‐Phenylalanine, l‐tryptophan, pyroglutamic acid, l‐tyrosine, l‐leucine and l‐valine were screened as hub metabolites in metabolic correlation network. Among them, increased l‐tryptophan and l‐tyrosine were altered hub metabolites, and they had a more significant impact on the metabolic change of PCOS. In addition, l‐tryptophan and l‐tyrosine were significantly positively associated with serum androgens levels in the PCOS. Our results suggest that disorders of amino acid metabolism, especially tryptophan and tyrosine metabolism, might play an important role in the development of PCOS in predisposed women without obesity and IR. Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in women of reproductive age. Some studies have investigated metabolic alterations in plasma and follicular fluid from PCOS patients, but they did not control for obesity or insulin resistance (IR); additionally, correlation analysis of metabolites is sparse. Accordingly, in this study, we aimed to examine metabolic differences owing to the pathogenesis of PCOS, identify the hub metabolites and investigate its associations with androgens. We applied GC–MS platform coupled with a correlation network approach to analyze follicular fluid samples from 32 PCOS patients without obesity and IR and 31 healthy women. Thirty significantly altered metabolites in PCOS patients were enriched in amino acid metabolism. l ‐Phenylalanine, l ‐tryptophan, pyroglutamic acid, l ‐tyrosine, l ‐leucine and l ‐valine were screened as hub metabolites in metabolic correlation network. Among them, increased l ‐tryptophan and l ‐tyrosine were altered hub metabolites, and they had a more significant impact on the metabolic change of PCOS. In addition, l ‐tryptophan and l ‐tyrosine were significantly positively associated with serum androgens levels in the PCOS. Our results suggest that disorders of amino acid metabolism, especially tryptophan and tyrosine metabolism, might play an important role in the development of PCOS in predisposed women without obesity and IR. |
| Author | Qiao, Jie Zhao, Yue Hang, Jing Hou, Entai |
| Author_xml | – sequence: 1 givenname: Entai orcidid: 0000-0002-0596-7195 surname: Hou fullname: Hou, Entai organization: Key Laboratory of Assisted Reproduction (Peking University) – sequence: 2 givenname: Yue surname: Zhao fullname: Zhao, Yue organization: Key Laboratory of Assisted Reproduction (Peking University) – sequence: 3 givenname: Jing surname: Hang fullname: Hang, Jing email: hang1124jing@163.com organization: Key Laboratory of Assisted Reproduction (Peking University) – sequence: 4 givenname: Jie orcidid: 0000-0003-2126-1376 surname: Qiao fullname: Qiao, Jie email: jie.qiao@263.net organization: Key Laboratory of Assisted Reproduction (Peking University) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32986877$$D View this record in MEDLINE/PubMed |
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| Keywords | l-tyrosine PCOS network analysis l-tryptophan amino acid metabolism |
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| Title | Metabolomics and correlation network analysis of follicular fluid reveals associations between l‐tryptophan, l‐tyrosine and polycystic ovary syndrome |
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