Assessment of endocrine disruptor impacts on lipid metabolism in a fatty acid-supplemented HepaRG human hepatic cell line

• Published in: Chemosphere (Oxford) Vol. 349; p. 140883
• Main Authors: Bernal, Kévin, Touma, Charbel, Le-Grand, Béatrice, Rose, Sophie, Degerli, Selenay, Genêt, Valentine, Lagadic-Gossmann, Dominique, Coumoul, Xavier, Martin-Chouly, Corinne, Langouët, Sophie, Blanc, Etienne B
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2024; Elsevier
• Series: Chemosphere
• Subjects: Ecology, environment; Endocrine disruptors; Endocrinology and metabolism; Health; HepaRG; Human health and pathology; Life Sciences; Lipid metabolism; MASLD; Mechanistic toxicology; Risk assessment; Toxicology; Endocrine disruptors; HepaRG; Lipid metabolism; MASLD; Risk assessment; Mechanistic toxicology

The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing worldwide. This disease encompasses several stages, from steatosis to steatohepatitis and, eventually, to fibrosis and cirrhosis. Exposure to environmental contaminants is one of the risk factors and an i...