A new method providing complementary explanation of the blood‐enriching function and mechanism of unprocessed Angelica sinensis and its four kinds of processed products based on tissue‐integrated metabolomics and confirmatory analysis

Angelica sinensis (AS) is a common Traditional Chinese Medicine used for tonifying blood in China. Unprocessed AS and its four kinds of processed products (ASs) are used to treat blood deficiency syndrome in the country. The different blood‐tonifying mechanisms of ASs remain unclear. In this work, a...

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Published in	Biomedical chromatography Vol. 36; no. 2; pp. e5252 - n/a
Main Authors	Ji, Peng, Li, Chen‐chen, Wei, Yan‐ming, Hua, Yong‐li, Yao, Wan‐ling, Wu, Fan‐lin, Zhang, Xiao‐song, Yuan, Zi‐wen, Zhao, Nian‐shou, Zhang, Ya‐hui, Wen, Yan‐qiao
Format	Journal Article
Language	English
Published	England 01.02.2022
Subjects	Amino Acids - metabolism Angelica sinensis (AS) Angelica sinensis - chemistry Animals blood deficiency syndrome (BDS) Drugs, Chinese Herbal - pharmacology Gas Chromatography-Mass Spectrometry Linoleic Acid - metabolism liver Liver - drug effects Liver - metabolism Male Medicine, Chinese Traditional Metabolome - drug effects metabolomics Metabolomics - methods Mice process spleen Spleen - drug effects Spleen - metabolism Angelica sinensis (AS) process blood deficiency syndrome (BDS) liver metabolomics spleen
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Abstract	Angelica sinensis (AS) is a common Traditional Chinese Medicine used for tonifying blood in China. Unprocessed AS and its four kinds of processed products (ASs) are used to treat blood deficiency syndrome in the country. The different blood‐tonifying mechanisms of ASs remain unclear. In this work, a novel method integrating metabolomics and hematological and biochemical parameters was established to provide a complementary explanation of blood supplementation mechanism of ASs. Our results revealed that different ASs exhibited various blood supplementation effect, and that AS parched with alcohol demonstrated the best blood supplementation effect. Eight metabolites from liver tissue and 12 metabolites from spleen tissue were considered to be potential biomarkers. These biomarkers were involved in four metabolic pathways. Correlation analysis results showed that l‐aspartic acid and l‐alanine (spleen tissue), linoleic acid, and l‐cystathionine (liver tissue) exhibited a high positive or negative correlation with the aforesaid biochemical indicators. The blood‐supplementation effect mechanism of ASs were related to four metabolic pathways. l‐Aspartic acid and l‐alanine (spleen tissue), linoleic acid, and l‐cystathionine (liver tissue) were the four key metabolites associated with the blood supplementation effect of ASs. This study gives a complementary explanation of the blood supplementation effect and mechanism of action of ASs.
AbstractList	Angelica sinensis (AS) is a common Traditional Chinese Medicine used for tonifying blood in China. Unprocessed AS and its four kinds of processed products (ASs) are used to treat blood deficiency syndrome in the country. The different blood‐tonifying mechanisms of ASs remain unclear. In this work, a novel method integrating metabolomics and hematological and biochemical parameters was established to provide a complementary explanation of blood supplementation mechanism of ASs. Our results revealed that different ASs exhibited various blood supplementation effect, and that AS parched with alcohol demonstrated the best blood supplementation effect. Eight metabolites from liver tissue and 12 metabolites from spleen tissue were considered to be potential biomarkers. These biomarkers were involved in four metabolic pathways. Correlation analysis results showed that l ‐aspartic acid and l ‐alanine (spleen tissue), linoleic acid, and l ‐cystathionine (liver tissue) exhibited a high positive or negative correlation with the aforesaid biochemical indicators. The blood‐supplementation effect mechanism of ASs were related to four metabolic pathways. l ‐Aspartic acid and l ‐alanine (spleen tissue), linoleic acid, and l ‐cystathionine (liver tissue) were the four key metabolites associated with the blood supplementation effect of ASs. This study gives a complementary explanation of the blood supplementation effect and mechanism of action of ASs. Angelica sinensis (AS) is a common Traditional Chinese Medicine used for tonifying blood in China. Unprocessed AS and its four kinds of processed products (ASs) are used to treat blood deficiency syndrome in the country. The different blood-tonifying mechanisms of ASs remain unclear. In this work, a novel method integrating metabolomics and hematological and biochemical parameters was established to provide a complementary explanation of blood supplementation mechanism of ASs. Our results revealed that different ASs exhibited various blood supplementation effect, and that AS parched with alcohol demonstrated the best blood supplementation effect. Eight metabolites from liver tissue and 12 metabolites from spleen tissue were considered to be potential biomarkers. These biomarkers were involved in four metabolic pathways. Correlation analysis results showed that l-aspartic acid and l-alanine (spleen tissue), linoleic acid, and l-cystathionine (liver tissue) exhibited a high positive or negative correlation with the aforesaid biochemical indicators. The blood-supplementation effect mechanism of ASs were related to four metabolic pathways. l-Aspartic acid and l-alanine (spleen tissue), linoleic acid, and l-cystathionine (liver tissue) were the four key metabolites associated with the blood supplementation effect of ASs. This study gives a complementary explanation of the blood supplementation effect and mechanism of action of ASs. Angelica sinensis (AS) is a common Traditional Chinese Medicine used for tonifying blood in China. Unprocessed AS and its four kinds of processed products (ASs) are used to treat blood deficiency syndrome in the country. The different blood-tonifying mechanisms of ASs remain unclear. In this work, a novel method integrating metabolomics and hematological and biochemical parameters was established to provide a complementary explanation of blood supplementation mechanism of ASs. Our results revealed that different ASs exhibited various blood supplementation effect, and that AS parched with alcohol demonstrated the best blood supplementation effect. Eight metabolites from liver tissue and 12 metabolites from spleen tissue were considered to be potential biomarkers. These biomarkers were involved in four metabolic pathways. Correlation analysis results showed that l-aspartic acid and l-alanine (spleen tissue), linoleic acid, and l-cystathionine (liver tissue) exhibited a high positive or negative correlation with the aforesaid biochemical indicators. The blood-supplementation effect mechanism of ASs were related to four metabolic pathways. l-Aspartic acid and l-alanine (spleen tissue), linoleic acid, and l-cystathionine (liver tissue) were the four key metabolites associated with the blood supplementation effect of ASs. This study gives a complementary explanation of the blood supplementation effect and mechanism of action of ASs.Angelica sinensis (AS) is a common Traditional Chinese Medicine used for tonifying blood in China. Unprocessed AS and its four kinds of processed products (ASs) are used to treat blood deficiency syndrome in the country. The different blood-tonifying mechanisms of ASs remain unclear. In this work, a novel method integrating metabolomics and hematological and biochemical parameters was established to provide a complementary explanation of blood supplementation mechanism of ASs. Our results revealed that different ASs exhibited various blood supplementation effect, and that AS parched with alcohol demonstrated the best blood supplementation effect. Eight metabolites from liver tissue and 12 metabolites from spleen tissue were considered to be potential biomarkers. These biomarkers were involved in four metabolic pathways. Correlation analysis results showed that l-aspartic acid and l-alanine (spleen tissue), linoleic acid, and l-cystathionine (liver tissue) exhibited a high positive or negative correlation with the aforesaid biochemical indicators. The blood-supplementation effect mechanism of ASs were related to four metabolic pathways. l-Aspartic acid and l-alanine (spleen tissue), linoleic acid, and l-cystathionine (liver tissue) were the four key metabolites associated with the blood supplementation effect of ASs. This study gives a complementary explanation of the blood supplementation effect and mechanism of action of ASs.
Author	Zhang, Xiao‐song Ji, Peng Li, Chen‐chen Yao, Wan‐ling Yuan, Zi‐wen Hua, Yong‐li Zhang, Ya‐hui Wen, Yan‐qiao Zhao, Nian‐shou Wei, Yan‐ming Wu, Fan‐lin
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Cites_doi	10.1080/13880209.2017.1281969 10.1016/j.jep.2011.11.049 10.1016/j.jep.2015.03.010 10.1016/j.ijbiomac.2014.03.025 10.3390/ijms13033583 10.1016/j.jep.2016.08.010 10.1016/j.jpba.2018.05.045 10.1055/s-2008-1034322 10.1021/jf200728e 10.1016/j.freeradbiomed.2017.02.019 10.1016/j.exphem.2010.03.012 10.1002/hep.1840170117 10.1016/j.procbio.2019.02.020 10.1016/0304-4165(84)90013-8 10.1016/S1875-5364(19)30031-7 10.1007/s10722-012-9795-9 10.1002/jat.1591 10.1038/srep46551 10.1016/j.tibs.2005.04.004 10.1039/C2AN36382H 10.1016/j.jep.2019.01.027 10.1016/j.jchromb.2018.02.035 10.1055/s-0035-1546081 10.1016/j.chroma.2014.04.042 10.1016/j.jnutbio.2014.01.010 10.1016/j.jchromb.2015.12.026 10.1186/1472-6882-10-79 10.1016/j.jep.2013.12.011 10.3748/wjg.v3.i3.180 10.1016/j.jep.2017.09.028
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Snippet	Angelica sinensis (AS) is a common Traditional Chinese Medicine used for tonifying blood in China. Unprocessed AS and its four kinds of processed products... Angelica sinensis (AS) is a common Traditional Chinese Medicine used for tonifying blood in China. Unprocessed AS and its four kinds of processed products...
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StartPage	e5252
SubjectTerms	Amino Acids - metabolism Angelica sinensis (AS) Angelica sinensis - chemistry Animals blood deficiency syndrome (BDS) Drugs, Chinese Herbal - pharmacology Gas Chromatography-Mass Spectrometry Linoleic Acid - metabolism liver Liver - drug effects Liver - metabolism Male Medicine, Chinese Traditional Metabolome - drug effects metabolomics Metabolomics - methods Mice process spleen Spleen - drug effects Spleen - metabolism
Title	A new method providing complementary explanation of the blood‐enriching function and mechanism of unprocessed Angelica sinensis and its four kinds of processed products based on tissue‐integrated metabolomics and confirmatory analysis
URI	https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fbmc.5252 https://www.ncbi.nlm.nih.gov/pubmed/34591996 https://www.proquest.com/docview/2578759356
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