Multiple complementary transcripts of pCMa1, a novel gene located at chromosome 11p15.1-2, and melanocytic cell transformation

• Published in: The Journal of pathology Vol. 197; no. 5; pp. 668 - 676
• Main Authors: Meije, Clifton B., Das, Pranab K., Jans, Miranda M. E., Hau, Chi, van der Wal, Allard C., Alders, Marielle, Hakvoort, Theodorus B. M., Weidle, Ulrich H., Lamers, Wouter H., Swart, Guido W. M.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.08.2002; Wiley
• Subjects: Biological and medical sciences; Cell Transformation, Neoplastic - genetics; Chromosomes, Human, Pair 11 - genetics; Dermatology; Disease Progression; DNA, Complementary - genetics; DNA, Neoplasm - genetics; FISH; Gene Library; General aspects (metabolism, cell proliferation, established cell line...); human melanoma; Humans; in situ hybridization; Medical sciences; Melanocytes - pathology; Melanoma - genetics; neoplastic progression; Nevus, Pigmented - genetics; Polymerase Chain Reaction - methods; RNA, Neoplasm - genetics; Skin Neoplasms - genetics; Transcription, Genetic; Tumor cell; Tumors; Tumors of the skin and soft tissue. Premalignant lesions; Human; Cell hybridization; In situ; Etiopathogenesis; Melanocyte; Melanoma; Exploration; Cell transformation; Northern blotting; Polymerase chain reaction; Tumor; Molecular biology; Southern blotting; Tumor cell

The cDNA clone pCMa1 (0.45 kb) is one of the 12 novel cDNAs, previously identified when comparing RNA expression profiles of melanocytes, naevus cells, and non‐metastatic melanoma cells. This clone did not reveal a unique long open reading frame. The pCMa1 gene localized to the distal, telomere prox...