miR‐124 affects dendritic cells function in CRSwNP by regulating exosomes secretion in nasal mucosal epithelial cells

• Published in: Flavour and fragrance journal Vol. 39; no. 6; pp. 396 - 411
• Main Authors: Zhang, Jie, Chen, Luqiu, Dong, Yuhan, Bing, Xin, Yuan, Fanyu, Gao, Xiaochen, Cao, Xue, Li, Chengzhilin, Liu, Chengcheng, Qi, Wenwen, Xia, Ming, Li, Xiuguo, Du, Hongjie
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01.11.2024
• Subjects: Apoptosis; Assaying; CD80 antigen; CD86 antigen; Cell culture; Cell cycle; Cells (biology); chronic rhinosinusitis with nasal polyps; coculture; Culture; Dendritic cells; enzyme-linked immunosorbent assay; Epithelial cells; Epithelium; Exosomes; flavor; Flow cytometry; Gene flow; genes; humans; Immunomodulation; interleukin-10; interleukin-12; interleukin-23; Internet; luciferase; Major histocompatibility complex; microRNA; MicroRNAs; miRNA; miR‐124; Mucosa; nasal mucosa; odors; Phenotypes; Polyps; Progenitor cells; Rab27a; Regulatory mechanisms (biology); Rhinitis; Rhinosinusitis; secretion; Signal transduction; Sinusitis; Therapeutic targets; therapeutics; TLR4 protein; TLR4/NF‐κB; Toll-like receptors; Western blotting
• ISSN: 0882-5734; 1099-1026
• DOI: 10.1002/ffj.3801

The intricate immunomodulatory mechanism underlying the onset and progression of chronic rhinosinusitis with nasal polyps (CRSwNP) in chronic sinusitis with nasal polyps remains poorly understood, particularly regarding the regulatory role of dendritic cells (DCs). MicroRNA has been identified as a...