Prenatal Buprenorphine Versus Methadone Exposure and Neonatal Outcomes: Systematic Review and Meta-Analysis

• Published in: American journal of epidemiology Vol. 180; no. 7; pp. 673 - 686
• Main Authors: Brogly, S. B., Saia, K. A., Walley, A. Y., Du, H. M., Sebastiani, P.
• Format: Journal Article
• Language: English
• Published: United States 01.10.2014
• Subjects: Buprenorphine - adverse effects; Buprenorphine - therapeutic use; Female; Humans; Infant, Newborn; Methadone - adverse effects; Methadone - therapeutic use; Models, Statistical; Neonatal Abstinence Syndrome - etiology; Neonatal Abstinence Syndrome - therapy; Opiate Substitution Treatment - adverse effects; Opioid-Related Disorders - drug therapy; Pregnancy; Pregnancy Complications - drug therapy; Treatment Outcome; buprenorphine; newborn; infant; methadone; neonatal abstinence syndrome; pregnancy

Increasing rates of maternal opioid use during pregnancy and neonatal withdrawal, termed neonatal abstinence syndrome (NAS), are public health concerns. Prenatal buprenorphine maintenance treatment (BMT) versus methadone maintenance treatment (MMT) may improve neonatal outcomes, but associations var...