In vivo anti-tumor effect of hybrid vaccine of dendritic cells and esophageal carcinoma cells on esophageal carcinoma cell line 109 in mice with severe combined immune deficiency

• Published in: World journal of gastroenterology : WJG Vol. 14; no. 8; pp. 1167 - 1174
• Main Authors: Guo, Guang-Hua, Chen, Su-Zuan, Yu, Jing, Zhang, Juan, Luo, Li-Li, Xie, Li-Hua, Su, Zhong-Jing, Dong, Hong-Mei, Xu, Hong, Wu, Li-Biao
• Format: Journal Article
• Language: English
• Published: United States Department of Gastroenterology,The First Affiliated Hospital of Shantou University Medical College,Shantou 515041,Guangdong Province,China 28.02.2008; The WJG Press and Baishideng
• Subjects: Animals; Antigens, CD34 - biosynthesis; Antigens, Neoplasm - chemistry; Cancer Vaccines - chemistry; Carcinoma - therapy; Cell Line, Tumor; Dendritic Cells - cytology; Esophageal Cancer; Esophageal Neoplasms - therapy; Humans; Immunoglobulin G - chemistry; Immunotherapy - methods; Mice; Mice, SCID; Models, Biological; Neoplasm Transplantation - methods; 免疫保护; 免疫疗法; 细胞融合; 食管癌; Esophageal carcinoma cells; Dendritic cells; Cell fusion; Immunotherapy; Immune protection

AIM： To develop a fusion vaccine of esophageal carcinoma cells and dendritic cells （DC） and observe its protective and therapeutic effect against esophageal carcinoma cell line 109 （EC109）. METHODS： The fusion vaccine was produced by fusing traditional polyethyleneglycol （PEG）, inducing cytokine, so...