Anti-inflammatory action of Athyrium multidentatum extract suppresses the LPS-induced TLR4 signaling pathway

• Published in: Journal of ethnopharmacology Vol. 217; pp. 220 - 227
• Main Authors: Han, Xiong-Zhe, Ma, Rui, Chen, Qi, Jin, Xin, Jin, Yuan-Zhe, An, Ren-Bo, Piao, Xuan-Mei, Lian, Mei-Lan, Quan, Lin-Hu, Jiang, Jun
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.05.2018
• Subjects: Acute lung injury; Athyrium multidentatum; Inflammation; Macrophage; MyD88; TRIF; NO; PGE2; Acute lung injury; IκB-α; Athyrium multidentatum; IL; COX-2; BALF; Inflammation; MAPK; MyD88; LPS; IFN; NF-κB; TNF-α; DEX; iNOS; qPCR; TRIF; TLR4; ALI; HPLC; ELISA; Macrophage

The aerial part of Athyrium multidentatum (Doll.) Ching (AM) is widely used in the northeastern region of China as an edible wild herb, but its medicinal value, especially its anti-inflammatory effect, has not been fully explored. To investigate the anti-inflammatory activity of AM and clarify the a...