Comprehensive Long-Term Outcomes Following Mandibular Distraction Osteogenesis

• Published in: The Cleft palate-craniofacial journal Vol. 62; no. 1; p. 108
• Main Authors: Kosyk, Mychajlo S, Salinero, Lauren K, Morales, Carrie Z, Shakir, Sameer, Cielo, Christopher M, Scott, Michelle, Nah, Hyun-Duck, Bartlett, Scott P, Taylor, Jesse A, Swanson, Jordan W
• Format: Journal Article
• Language: English
• Published: United States 01.01.2025
• Subjects: Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Infant; Male; Mandible - surgery; Osteogenesis, Distraction - methods; Postoperative Complications; Treatment Outcome; tooth abnormalities; scarring; mandibular micrognathia; nerve injuries; distraction osteogenesis
• ISSN: 1545-1569
• DOI: 10.1177/10556656231206884

To describe long-term outcomes and complications following mandibular distraction osteogenesis (MDO) in a diverse patient cohort. Cross-sectional study. Single tertiary-care pediatric center. Forty-eight patients previously undergoing MDO with minimum 4-year follow-up. Respiratory outcomes, feeding patterns, dental development, motor/sensory nerve function, temporo-mandibular joint function, and postsurgical scarring. Forty-six patients with a median age of 7 years were evaluated. Of 20 nonsyndromic patients, none required additional airway procedures, none required continuous positive airway pressure (CPAP) during sleep, and 19 (95%) fed exclusively by mouth. Among 26 syndromic patients, 7 (27%) required CPAP and 8 (31%) were tube fed. Permanent first molar differences were seen in the majority of subjects; patterns of damage interfering with function were more common in syndromic (13/28, 46%) compared to nonsyndromic (5/24, 21%;  = .014) subjects. MDO prior to age two was associated with more frequent and worse dental damage ( = .001). Inferior alveolar nerve and marginal mandibular nerve function were fully intact in 37 (80%) and 39 (85%) of patients, respectively. Three patients (6%), all with associated genetic syndromes, demonstrated severe nerve impairment. By the Vancouver scar scale, ≥ 80% of surgical scars were rated in the most favorable category for each quality assessed. Temporomandibular joint dysfunction was rare. MDO shows highly favorable long-term respiratory, feeding, nerve, and scar outcomes in nonsyndromic patients, although permanent molar changes not precluding tooth viability are commonly seen. Patients with associated syndromes demonstrate respiratory and feeding benefits, but higher rates of dental and nerve abnormalities.