A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men
A homozygous mutant ( ALDH2 ⁎ 2/ ⁎ 2) of the gene for mitochondrial aldehyde dehydrogenase 2 ( ALDH2) at codon 487 was reported to be associated with myocardial infarction (MI) among Japanese men. However, such an association has never been studied in a Korean population. The subjects consisted of 1...
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| Published in | Clinica chimica acta Vol. 382; no. 1; pp. 43 - 47 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.07.2007
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| Subjects | |
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| Abstract | A homozygous mutant (
ALDH2
⁎
2/
⁎
2) of the gene for mitochondrial aldehyde dehydrogenase 2 (
ALDH2) at codon 487 was reported to be associated with myocardial infarction (MI) among Japanese men. However, such an association has never been studied in a Korean population.
The subjects consisted of 122 men (60–81 y) with MI recruited randomly from Yonsei University Medical Center, Korea. A total of 439 men (60–84 y) without MI were selected as controls from the Ansan Geriatric Study.
ALDH2 genotypes were determined using the TaqMan fluorogenic 5′ nuclease polymerase chain reaction assay.
Genotypes carrying the mutant
ALDH2 allele (
ALDH2
⁎
1/
⁎
2 plus
ALDH2
⁎
2/
⁎
2) were significantly more frequent in patients with MI than in the controls (42.6%
vs. 30.5%,
P
=
0.0163). Multiple logistic regression analysis revealed that
ALDH2
⁎
1/
⁎
2 plus
ALDH2
⁎
2/
⁎
2, together with abnormal high density lipoprotein cholesterol and elevated body mass index, was an independent risk factor for MI in elderly Korean men (odds ratio
=
1.976, 95% CI: 1.202–3.248).
ALDH2 polymorphisms may play an important role in the pathogenesis of MI in elderly Korean men. |
|---|---|
| AbstractList | A homozygous mutant (ALDH2*2/*2) of the gene for mitochondrial aldehyde dehydrogenase 2 (ALDH2) at codon 487 was reported to be associated with myocardial infarction (MI) among Japanese men. However, such an association has never been studied in a Korean population.
The subjects consisted of 122 men (60-81 y) with MI recruited randomly from Yonsei University Medical Center, Korea. A total of 439 men (60-84 y) without MI were selected as controls from the Ansan Geriatric Study. ALDH2 genotypes were determined using the TaqMan fluorogenic 5' nuclease polymerase chain reaction assay.
Genotypes carrying the mutant ALDH2 allele (ALDH2*1/*2 plus ALDH2*2/*2) were significantly more frequent in patients with MI than in the controls (42.6% vs. 30.5%, P=0.0163). Multiple logistic regression analysis revealed that ALDH2*1/*2 plus ALDH2*2/*2, together with abnormal high density lipoprotein cholesterol and elevated body mass index, was an independent risk factor for MI in elderly Korean men (odds ratio=1.976, 95% CI: 1.202-3.248).
ALDH2 polymorphisms may play an important role in the pathogenesis of MI in elderly Korean men. A homozygous mutant ( ALDH2 ⁎ 2/ ⁎ 2) of the gene for mitochondrial aldehyde dehydrogenase 2 ( ALDH2) at codon 487 was reported to be associated with myocardial infarction (MI) among Japanese men. However, such an association has never been studied in a Korean population. The subjects consisted of 122 men (60–81 y) with MI recruited randomly from Yonsei University Medical Center, Korea. A total of 439 men (60–84 y) without MI were selected as controls from the Ansan Geriatric Study. ALDH2 genotypes were determined using the TaqMan fluorogenic 5′ nuclease polymerase chain reaction assay. Genotypes carrying the mutant ALDH2 allele ( ALDH2 ⁎ 1/ ⁎ 2 plus ALDH2 ⁎ 2/ ⁎ 2) were significantly more frequent in patients with MI than in the controls (42.6% vs. 30.5%, P = 0.0163). Multiple logistic regression analysis revealed that ALDH2 ⁎ 1/ ⁎ 2 plus ALDH2 ⁎ 2/ ⁎ 2, together with abnormal high density lipoprotein cholesterol and elevated body mass index, was an independent risk factor for MI in elderly Korean men (odds ratio = 1.976, 95% CI: 1.202–3.248). ALDH2 polymorphisms may play an important role in the pathogenesis of MI in elderly Korean men. |
| Author | Jo, Inho Park, Moon Ho Jang, Yangsoo Han, Changsu Park, Hyun-Young Kim, Eun-Kyung Jo, Sangmee Ahn Song, Byung Joon |
| Author_xml | – sequence: 1 givenname: Sangmee Ahn surname: Jo fullname: Jo, Sangmee Ahn organization: Center for Biomedical Sciences, National Institute of Health, 194 Tongil-ro, Eunpyeong-gu, Seoul 122-701, South Korea – sequence: 2 givenname: Eun-Kyung surname: Kim fullname: Kim, Eun-Kyung organization: Center for Biomedical Sciences, National Institute of Health, 194 Tongil-ro, Eunpyeong-gu, Seoul 122-701, South Korea – sequence: 3 givenname: Moon Ho surname: Park fullname: Park, Moon Ho organization: The Geriatric Health Clinic and Research Institute, Korea University Hospital, 516 Gojan-dong, Ansan-city, Kyeonggi-do 425-707, South Korea – sequence: 4 givenname: Changsu surname: Han fullname: Han, Changsu organization: The Geriatric Health Clinic and Research Institute, Korea University Hospital, 516 Gojan-dong, Ansan-city, Kyeonggi-do 425-707, South Korea – sequence: 5 givenname: Hyun-Young surname: Park fullname: Park, Hyun-Young organization: Center for Biomedical Sciences, National Institute of Health, 194 Tongil-ro, Eunpyeong-gu, Seoul 122-701, South Korea – sequence: 6 givenname: Yangsoo surname: Jang fullname: Jang, Yangsoo organization: Cardiovascular Research Institute, Yonsei University Medical Center, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea – sequence: 7 givenname: Byung Joon surname: Song fullname: Song, Byung Joon organization: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA – sequence: 8 givenname: Inho surname: Jo fullname: Jo, Inho email: inhojo@nih.go.kr organization: Center for Biomedical Sciences, National Institute of Health, 194 Tongil-ro, Eunpyeong-gu, Seoul 122-701, South Korea |
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| Cites_doi | 10.1002/(SICI)1097-0142(19960515)77:10<1986::AID-CNCR4>3.0.CO;2-F 10.1016/S0021-9150(97)00156-1 10.1002/gps.1401 10.1016/S0009-8981(02)00235-8 10.1073/pnas.82.11.3771 10.1097/00004872-200109000-00002 10.1006/bbrc.2000.2923 10.1111/j.1530-0277.1999.tb04217.x 10.1016/S0891-5849(00)00497-4 10.1002/gps.1664 10.1016/S0895-7061(99)00238-1 10.1016/0741-8329(85)90024-2 10.1093/ije/30.4.724 10.1186/1471-2458-7-10 10.1136/bmj.308.6939.1263 10.1016/S0021-9258(17)36725-X 10.1016/S0140-6736(82)92722-2 10.1161/01.HYP.9.2.111 10.1056/NEJMoa022095 10.1186/1471-2458-6-153 10.1016/S0197-4580(03)00114-3 10.1001/jama.285.19.2486 10.1093/jn/131.5.1401 10.1291/hypres.25.677 10.1046/j.1365-2796.2001.00885.x 10.1291/hypres.24.365 10.1038/oby.2005.183 10.1016/j.archger.2004.09.003 10.1016/S0369-8114(01)00242-5 10.1161/01.CIR.90.1.583 10.1016/S0753-3322(99)80121-8 |
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| Keywords | Myocardial infarction Aldehyde dehydrogenase 2 ALDH Koreans Glu487Lys Polymorphism |
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| References | Jo, Ahn, Lee, Shin, Lee, Shin (bib26) 2001; 19 Spengler, Singer (bib19) 1988; 48 Higuchi (bib21) 1994; 2 Tsuruta, Adachi, Hirai, Fujuira, Imaizumi (bib3) 2000; 13 Lieber (bib13) 1999; 23 World Health Organization/International Association for the Study of Obesity/International Obesity Task Force (bib27) 2000 Kim, Stewart, Shin, Jung, Yoon (bib33) 2004; 25 Harada, Agarwal, Goedde, Tagaki, Ishigawa (bib20) 1982; 2 Park, Jo, Jo (bib23) 2006; 6 Marmot (bib7) 2001; 30 Marmot, Elliot, Shipley (bib2) 1994; 308 MacMahon (bib1) 1987; 9 Kim, Hwang, Woo, Kim, Jo, Jo (bib28) 2005; 13 Kerry, Abbey (bib10) 1997; 135 Yoshida, Ikawa, Hsu, Tani (bib16) 1985; 2 Cleophas (bib6) 1999; 53 Park, Jo, Park, Kim, Jo, Shin (bib30) 2005; 40 Jo, Park, Jo, Ryu, Han (bib24) 2007; 22 Shin, Stewart, Kim (bib34) 2005; 20 Mukamal, Conigrave, Mittleman (bib5) 2003; 348 Yokoyama, Muramatsu, Ohmori (bib17) 1996; 77 Gronbaek (bib9) 2001; 250 Gemma, Vichi, Testai (bib14) 2006; 42 Kamino, Nagasaka, Imagawa (bib35) 2000; 273 Takagi, Iwai, Yamauchi (bib32) 2002; 25 Woo, Han, Jo (bib25) 2007; 7 Wollin, Jones (bib8) 2001; 131 Farres, Wang, Takahashi, Cunningham, Wang, Weiner (bib18) 1994; 269 Tunstall-Pedoe, Kuulasmaa, Amouyel, Arveiler, Rajakangas, Pajak (bib22) 1994; 90 Hsu, Tani, Fujiyoshi, Kurachi, Yoshida (bib15) 1985; 82 (bib31) 2001; 285 Takagi, Baba, Iwai (bib4) 2001; 24 Yoon, Moon, Shin, Kim, Jo, Jo (bib29) 2002; 324 Abu-Amsha, Burke, Mori, Beilin, Puddey, Croft (bib11) 2001; 30 Agarwal (bib12) 2001; 49 Tsuruta (10.1016/j.cca.2007.03.016_bib3) 2000; 13 Gemma (10.1016/j.cca.2007.03.016_bib14) 2006; 42 Gronbaek (10.1016/j.cca.2007.03.016_bib9) 2001; 250 Lieber (10.1016/j.cca.2007.03.016_bib13) 1999; 23 Yoon (10.1016/j.cca.2007.03.016_bib29) 2002; 324 Jo (10.1016/j.cca.2007.03.016_bib26) 2001; 19 Mukamal (10.1016/j.cca.2007.03.016_bib5) 2003; 348 Wollin (10.1016/j.cca.2007.03.016_bib8) 2001; 131 Agarwal (10.1016/j.cca.2007.03.016_bib12) 2001; 49 Farres (10.1016/j.cca.2007.03.016_bib18) 1994; 269 Kim (10.1016/j.cca.2007.03.016_bib33) 2004; 25 Spengler (10.1016/j.cca.2007.03.016_bib19) 1988; 48 World Health Organization/International Association for the Study of Obesity/International Obesity Task Force (10.1016/j.cca.2007.03.016_bib27) 2000 Takagi (10.1016/j.cca.2007.03.016_bib4) 2001; 24 Higuchi (10.1016/j.cca.2007.03.016_bib21) 1994; 2 Shin (10.1016/j.cca.2007.03.016_bib34) 2005; 20 Marmot (10.1016/j.cca.2007.03.016_bib2) 1994; 308 Abu-Amsha (10.1016/j.cca.2007.03.016_bib11) 2001; 30 Takagi (10.1016/j.cca.2007.03.016_bib32) 2002; 25 (10.1016/j.cca.2007.03.016_bib31) 2001; 285 Kim (10.1016/j.cca.2007.03.016_bib28) 2005; 13 Kerry (10.1016/j.cca.2007.03.016_bib10) 1997; 135 Marmot (10.1016/j.cca.2007.03.016_bib7) 2001; 30 Kamino (10.1016/j.cca.2007.03.016_bib35) 2000; 273 Yoshida (10.1016/j.cca.2007.03.016_bib16) 1985; 2 Harada (10.1016/j.cca.2007.03.016_bib20) 1982; 2 Tunstall-Pedoe (10.1016/j.cca.2007.03.016_bib22) 1994; 90 Jo (10.1016/j.cca.2007.03.016_bib24) 2007; 22 Yokoyama (10.1016/j.cca.2007.03.016_bib17) 1996; 77 Cleophas (10.1016/j.cca.2007.03.016_bib6) 1999; 53 Park (10.1016/j.cca.2007.03.016_bib30) 2005; 40 Woo (10.1016/j.cca.2007.03.016_bib25) 2007; 7 Hsu (10.1016/j.cca.2007.03.016_bib15) 1985; 82 MacMahon (10.1016/j.cca.2007.03.016_bib1) 1987; 9 Park (10.1016/j.cca.2007.03.016_bib23) 2006; 6 |
| References_xml | – volume: 135 start-page: 93 year: 1997 end-page: 102 ident: bib10 article-title: Red wine and fractionated phenolic compounds prepared from red wine inhibit low density lipoprotein oxidation in vitro publication-title: Atherosclerosis contributor: fullname: Abbey – volume: 24 start-page: 365 year: 2001 end-page: 370 ident: bib4 article-title: The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study publication-title: Hypertens Res contributor: fullname: Iwai – volume: 90 start-page: 583 year: 1994 end-page: 612 ident: bib22 article-title: Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents publication-title: Circulation contributor: fullname: Pajak – volume: 25 start-page: 677 year: 2002 end-page: 681 ident: bib32 article-title: Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men publication-title: Hypertens Res contributor: fullname: Yamauchi – volume: 2 start-page: 29 year: 1994 end-page: 34 ident: bib21 article-title: Polymorphisms of ethanol metabolizing enzyme genes and alcoholism publication-title: Alcohol Alcohol Suppl contributor: fullname: Higuchi – volume: 9 start-page: 111 year: 1987 end-page: 121 ident: bib1 article-title: Alcohol consumption and hypertension publication-title: Hypertension contributor: fullname: MacMahon – volume: 131 start-page: 1401 year: 2001 end-page: 1404 ident: bib8 article-title: Alcohol, red wine and cardiovascular disease publication-title: J Nutr contributor: fullname: Jones – volume: 25 start-page: 295 year: 2004 end-page: 301 ident: bib33 article-title: Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population publication-title: Neurobiol Aging contributor: fullname: Yoon – volume: 6 start-page: 153 year: 2006 ident: bib23 article-title: No difference in stroke knowledge between Korean adherents to traditional and western medicine—the AGE study: an epidemiological study publication-title: BMC Public Health contributor: fullname: Jo – volume: 250 start-page: 291 year: 2001 end-page: 308 ident: bib9 article-title: Factors influencing the relation between alcohol and mortality—with focus on wine publication-title: J Intern Med contributor: fullname: Gronbaek – volume: 7 start-page: 10 year: 2007 ident: bib25 article-title: Morbidity and related factors among elderly people in South Korea: results from the Ansan Geriatric (AGE) cohort study publication-title: BMC Public Health contributor: fullname: Jo – volume: 269 start-page: 13854 year: 1994 end-page: 13860 ident: bib18 article-title: Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase publication-title: J Biol Chem contributor: fullname: Weiner – volume: 285 start-page: 2486 year: 2001 end-page: 2497 ident: bib31 article-title: Expert panel on detection, evaluation and treatment of high blood cholesterol in adults. Executive summary of the third report of the National Cholesterol education Program (NCEP) Expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III) publication-title: JAMA – volume: 2 start-page: 827 year: 1982 ident: bib20 article-title: Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan publication-title: Lancet contributor: fullname: Ishigawa – volume: 13 start-page: 1510 year: 2005 end-page: 1514 ident: bib28 article-title: Body mass index cut-offs for underweight, overweight and obesity in South Korean schoolgirls publication-title: Obes Res contributor: fullname: Jo – volume: 273 start-page: 192 year: 2000 end-page: 196 ident: bib35 article-title: Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population publication-title: Biochem Biophys Res Commun contributor: fullname: Imagawa – volume: 82 start-page: 3771 year: 1985 end-page: 3775 ident: bib15 article-title: Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2 publication-title: Proc Natl Acad Sci U S A contributor: fullname: Yoshida – volume: 77 start-page: 1986 year: 1996 end-page: 1990 ident: bib17 article-title: Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics publication-title: Cancer contributor: fullname: Ohmori – volume: 48 start-page: 4804 year: 1988 end-page: 4806 ident: bib19 article-title: Formation of interstrand cross-links in chloroacetaldehyde-treated DNA demonstrated by ethidium bromide fluorescence publication-title: Cancer Res contributor: fullname: Singer – volume: 2 start-page: 103 year: 1985 end-page: 106 ident: bib16 article-title: Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases publication-title: Alcohol contributor: fullname: Tani – year: 2000 ident: bib27 article-title: The Asia-Pacific perspective: redefining obesity and its treatment contributor: fullname: World Health Organization/International Association for the Study of Obesity/International Obesity Task Force – volume: 30 start-page: 636 year: 2001 end-page: 642 ident: bib11 article-title: Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects publication-title: Free Radic Biol Med contributor: fullname: Croft – volume: 324 start-page: 113 year: 2002 end-page: 120 ident: bib29 article-title: Smoking status-dependent association of the 27-bp repeat polymorphism in intron 4 of endothelial nitric oxide synthase gene with plasma nitric oxide concentrations publication-title: Clin Chim Acta contributor: fullname: Jo – volume: 19 start-page: 1523 year: 2001 end-page: 1532 ident: bib26 article-title: Prevalence, awareness, treatment, control and risk factors of hypertension in Korea: the Ansan study publication-title: J Hypertens contributor: fullname: Shin – volume: 30 start-page: 724 year: 2001 end-page: 729 ident: bib7 article-title: Alcohol and coronary heart disease publication-title: Int J Epidemiol contributor: fullname: Marmot – volume: 348 start-page: 109 year: 2003 end-page: 118 ident: bib5 article-title: Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men publication-title: N Engl J Med contributor: fullname: Mittleman – volume: 23 start-page: 991 year: 1999 end-page: 1007 ident: bib13 article-title: Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968–1998)—a review publication-title: Alcohol Clin Exp Res contributor: fullname: Lieber – volume: 22 start-page: 218 year: 2007 end-page: 223 ident: bib24 article-title: Usefulness of Beck Depression Inventory (BDI) in the Korean elderly population publication-title: Int J Geriatr Psychiatry contributor: fullname: Han – volume: 40 start-page: 265 year: 2005 end-page: 273 ident: bib30 article-title: Cerebral white matter lesions and hypertension status in the elderly Korean: the Ansan Study publication-title: Arch Gerontol Geriatr contributor: fullname: Shin – volume: 13 start-page: 482 year: 2000 end-page: 487 ident: bib3 article-title: Association between alcohol intake and development of hypertension in Japanese normotensive men: 12-year follow-up study publication-title: Am J Hypertens contributor: fullname: Imaizumi – volume: 20 start-page: 1075 year: 2005 end-page: 1080 ident: bib34 article-title: Mitochondrial aldehyde dehydrogenase polymorphism is not associated with incidence of Alzheimer' s disease publication-title: Int J Geriatr Psychiatry contributor: fullname: Kim – volume: 308 start-page: 1263 year: 1994 end-page: 1267 ident: bib2 article-title: Alcohol and blood pressure: the INTERSALT study publication-title: BMJ contributor: fullname: Shipley – volume: 49 start-page: 703 year: 2001 end-page: 709 ident: bib12 article-title: Genetic polymorphisms of alcohol metabolizing enzymes publication-title: Pathol Biol contributor: fullname: Agarwal – volume: 53 start-page: 417 year: 1999 end-page: 423 ident: bib6 article-title: Wine, beer and spirits and the risk of myocardial infarction: a systematic review publication-title: Biomed Pharmacother contributor: fullname: Cleophas – volume: 42 start-page: 8 year: 2006 end-page: 16 ident: bib14 article-title: Individual susceptibility and alcohol effects: biochemical and genetic aspects publication-title: Ann Ist Super Sanita contributor: fullname: Testai – volume: 77 start-page: 1986 year: 1996 ident: 10.1016/j.cca.2007.03.016_bib17 article-title: Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics publication-title: Cancer doi: 10.1002/(SICI)1097-0142(19960515)77:10<1986::AID-CNCR4>3.0.CO;2-F contributor: fullname: Yokoyama – volume: 135 start-page: 93 year: 1997 ident: 10.1016/j.cca.2007.03.016_bib10 article-title: Red wine and fractionated phenolic compounds prepared from red wine inhibit low density lipoprotein oxidation in vitro publication-title: Atherosclerosis doi: 10.1016/S0021-9150(97)00156-1 contributor: fullname: Kerry – volume: 20 start-page: 1075 year: 2005 ident: 10.1016/j.cca.2007.03.016_bib34 article-title: Mitochondrial aldehyde dehydrogenase polymorphism is not associated with incidence of Alzheimer' s disease publication-title: Int J Geriatr Psychiatry doi: 10.1002/gps.1401 contributor: fullname: Shin – volume: 324 start-page: 113 year: 2002 ident: 10.1016/j.cca.2007.03.016_bib29 article-title: Smoking status-dependent association of the 27-bp repeat polymorphism in intron 4 of endothelial nitric oxide synthase gene with plasma nitric oxide concentrations publication-title: Clin Chim Acta doi: 10.1016/S0009-8981(02)00235-8 contributor: fullname: Yoon – volume: 82 start-page: 3771 year: 1985 ident: 10.1016/j.cca.2007.03.016_bib15 article-title: Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.82.11.3771 contributor: fullname: Hsu – volume: 2 start-page: 29 year: 1994 ident: 10.1016/j.cca.2007.03.016_bib21 article-title: Polymorphisms of ethanol metabolizing enzyme genes and alcoholism publication-title: Alcohol Alcohol Suppl contributor: fullname: Higuchi – volume: 19 start-page: 1523 year: 2001 ident: 10.1016/j.cca.2007.03.016_bib26 article-title: Prevalence, awareness, treatment, control and risk factors of hypertension in Korea: the Ansan study publication-title: J Hypertens doi: 10.1097/00004872-200109000-00002 contributor: fullname: Jo – volume: 273 start-page: 192 year: 2000 ident: 10.1016/j.cca.2007.03.016_bib35 article-title: Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.2000.2923 contributor: fullname: Kamino – volume: 23 start-page: 991 year: 1999 ident: 10.1016/j.cca.2007.03.016_bib13 article-title: Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968–1998)—a review publication-title: Alcohol Clin Exp Res doi: 10.1111/j.1530-0277.1999.tb04217.x contributor: fullname: Lieber – volume: 30 start-page: 636 year: 2001 ident: 10.1016/j.cca.2007.03.016_bib11 article-title: Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(00)00497-4 contributor: fullname: Abu-Amsha – volume: 22 start-page: 218 year: 2007 ident: 10.1016/j.cca.2007.03.016_bib24 article-title: Usefulness of Beck Depression Inventory (BDI) in the Korean elderly population publication-title: Int J Geriatr Psychiatry doi: 10.1002/gps.1664 contributor: fullname: Jo – volume: 13 start-page: 482 year: 2000 ident: 10.1016/j.cca.2007.03.016_bib3 article-title: Association between alcohol intake and development of hypertension in Japanese normotensive men: 12-year follow-up study publication-title: Am J Hypertens doi: 10.1016/S0895-7061(99)00238-1 contributor: fullname: Tsuruta – volume: 2 start-page: 103 year: 1985 ident: 10.1016/j.cca.2007.03.016_bib16 article-title: Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases publication-title: Alcohol doi: 10.1016/0741-8329(85)90024-2 contributor: fullname: Yoshida – volume: 30 start-page: 724 year: 2001 ident: 10.1016/j.cca.2007.03.016_bib7 article-title: Alcohol and coronary heart disease publication-title: Int J Epidemiol doi: 10.1093/ije/30.4.724 contributor: fullname: Marmot – year: 2000 ident: 10.1016/j.cca.2007.03.016_bib27 contributor: fullname: World Health Organization/International Association for the Study of Obesity/International Obesity Task Force – volume: 7 start-page: 10 year: 2007 ident: 10.1016/j.cca.2007.03.016_bib25 article-title: Morbidity and related factors among elderly people in South Korea: results from the Ansan Geriatric (AGE) cohort study publication-title: BMC Public Health doi: 10.1186/1471-2458-7-10 contributor: fullname: Woo – volume: 308 start-page: 1263 year: 1994 ident: 10.1016/j.cca.2007.03.016_bib2 article-title: Alcohol and blood pressure: the INTERSALT study publication-title: BMJ doi: 10.1136/bmj.308.6939.1263 contributor: fullname: Marmot – volume: 269 start-page: 13854 year: 1994 ident: 10.1016/j.cca.2007.03.016_bib18 article-title: Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase publication-title: J Biol Chem doi: 10.1016/S0021-9258(17)36725-X contributor: fullname: Farres – volume: 48 start-page: 4804 year: 1988 ident: 10.1016/j.cca.2007.03.016_bib19 article-title: Formation of interstrand cross-links in chloroacetaldehyde-treated DNA demonstrated by ethidium bromide fluorescence publication-title: Cancer Res contributor: fullname: Spengler – volume: 2 start-page: 827 year: 1982 ident: 10.1016/j.cca.2007.03.016_bib20 article-title: Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan publication-title: Lancet doi: 10.1016/S0140-6736(82)92722-2 contributor: fullname: Harada – volume: 9 start-page: 111 year: 1987 ident: 10.1016/j.cca.2007.03.016_bib1 article-title: Alcohol consumption and hypertension publication-title: Hypertension doi: 10.1161/01.HYP.9.2.111 contributor: fullname: MacMahon – volume: 348 start-page: 109 year: 2003 ident: 10.1016/j.cca.2007.03.016_bib5 article-title: Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men publication-title: N Engl J Med doi: 10.1056/NEJMoa022095 contributor: fullname: Mukamal – volume: 6 start-page: 153 year: 2006 ident: 10.1016/j.cca.2007.03.016_bib23 article-title: No difference in stroke knowledge between Korean adherents to traditional and western medicine—the AGE study: an epidemiological study publication-title: BMC Public Health doi: 10.1186/1471-2458-6-153 contributor: fullname: Park – volume: 25 start-page: 295 year: 2004 ident: 10.1016/j.cca.2007.03.016_bib33 article-title: Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population publication-title: Neurobiol Aging doi: 10.1016/S0197-4580(03)00114-3 contributor: fullname: Kim – volume: 285 start-page: 2486 year: 2001 ident: 10.1016/j.cca.2007.03.016_bib31 publication-title: JAMA doi: 10.1001/jama.285.19.2486 – volume: 131 start-page: 1401 year: 2001 ident: 10.1016/j.cca.2007.03.016_bib8 article-title: Alcohol, red wine and cardiovascular disease publication-title: J Nutr doi: 10.1093/jn/131.5.1401 contributor: fullname: Wollin – volume: 25 start-page: 677 year: 2002 ident: 10.1016/j.cca.2007.03.016_bib32 article-title: Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men publication-title: Hypertens Res doi: 10.1291/hypres.25.677 contributor: fullname: Takagi – volume: 250 start-page: 291 year: 2001 ident: 10.1016/j.cca.2007.03.016_bib9 article-title: Factors influencing the relation between alcohol and mortality—with focus on wine publication-title: J Intern Med doi: 10.1046/j.1365-2796.2001.00885.x contributor: fullname: Gronbaek – volume: 24 start-page: 365 year: 2001 ident: 10.1016/j.cca.2007.03.016_bib4 article-title: The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study publication-title: Hypertens Res doi: 10.1291/hypres.24.365 contributor: fullname: Takagi – volume: 13 start-page: 1510 year: 2005 ident: 10.1016/j.cca.2007.03.016_bib28 article-title: Body mass index cut-offs for underweight, overweight and obesity in South Korean schoolgirls publication-title: Obes Res doi: 10.1038/oby.2005.183 contributor: fullname: Kim – volume: 40 start-page: 265 year: 2005 ident: 10.1016/j.cca.2007.03.016_bib30 article-title: Cerebral white matter lesions and hypertension status in the elderly Korean: the Ansan Study publication-title: Arch Gerontol Geriatr doi: 10.1016/j.archger.2004.09.003 contributor: fullname: Park – volume: 49 start-page: 703 year: 2001 ident: 10.1016/j.cca.2007.03.016_bib12 article-title: Genetic polymorphisms of alcohol metabolizing enzymes publication-title: Pathol Biol doi: 10.1016/S0369-8114(01)00242-5 contributor: fullname: Agarwal – volume: 90 start-page: 583 year: 1994 ident: 10.1016/j.cca.2007.03.016_bib22 article-title: Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents publication-title: Circulation doi: 10.1161/01.CIR.90.1.583 contributor: fullname: Tunstall-Pedoe – volume: 42 start-page: 8 year: 2006 ident: 10.1016/j.cca.2007.03.016_bib14 article-title: Individual susceptibility and alcohol effects: biochemical and genetic aspects publication-title: Ann Ist Super Sanita contributor: fullname: Gemma – volume: 53 start-page: 417 year: 1999 ident: 10.1016/j.cca.2007.03.016_bib6 article-title: Wine, beer and spirits and the risk of myocardial infarction: a systematic review publication-title: Biomed Pharmacother doi: 10.1016/S0753-3322(99)80121-8 contributor: fullname: Cleophas |
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| Snippet | A homozygous mutant (
ALDH2
⁎
2/
⁎
2) of the gene for mitochondrial aldehyde dehydrogenase 2 (
ALDH2) at codon 487 was reported to be associated with... A homozygous mutant (ALDH2*2/*2) of the gene for mitochondrial aldehyde dehydrogenase 2 (ALDH2) at codon 487 was reported to be associated with myocardial... |
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| StartPage | 43 |
| SubjectTerms | Age Factors Aged, 80 and over Aldehyde Dehydrogenase - blood Aldehyde Dehydrogenase - genetics Aldehyde dehydrogenase 2 Aldehyde Dehydrogenase, Mitochondrial Genetic Predisposition to Disease Homozygote Humans Korea Koreans Male Middle Aged Myocardial infarction Myocardial Infarction - ethnology Myocardial Infarction - genetics Polymorphism Polymorphism, Single Nucleotide - genetics |
| Title | A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men |
| URI | https://dx.doi.org/10.1016/j.cca.2007.03.016 https://www.ncbi.nlm.nih.gov/pubmed/17459359 |
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