FTIR spectroscopy of biofluids revisited: an automated approach to spectral biomarker identification

• Published in: Analyst (London) Vol. 138; no. 14; pp. 4092 - 4102
• Main Authors: Ollesch, Julian, Drees, Steffen L., Heise, H. Michael, Behrens, Thomas, Brüning, Thomas, Gerwert, Klaus
• Format: Journal Article
• Language: English
• Published: England 21.07.2013
• Subjects: Aged; Biomarkers; Biomarkers, Tumor - blood; Bladder; Blood; Cancer; Carcinoma, Papillary - blood; Carcinoma, Papillary - diagnosis; Case-Control Studies; Discriminant Analysis; Droplets; Female; Humans; Male; Microscopy, Atomic Force; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local - blood; Neoplasm Recurrence, Local - diagnosis; Neoplasm Staging; Patients; Spectra; Spectroscopy, Fourier Transform Infrared - methods; Urinary Bladder - pathology; Urinary Bladder Neoplasms - blood; Urinary Bladder Neoplasms - diagnosis

The extraction of disease specific information from Fourier transform infrared (FTIR) spectra of human body fluids demands the highest standards of accuracy and reproducibility of measurements because the expected spectral differences between healthy and diseased subjects are very small in relation...