Associations between paraoxonase-1 activity and therapeutic drug monitoring indicators in schizophrenia patients treated with olanzapine: A cross-sectional study

• Published in: Journal of psychopharmacology (Oxford) Vol. 39; no. 2; p. 141
• Main Authors: Wu, Tzu-Hua, Hu, Shu-Chin, Sylfa, Nailis, Liao, Jiahn-Haur, Raza, Ahmad, Chen, Bi-Li, Chen, Chun-Hsin, Lu, Mong-Liang
• Format: Journal Article
• Language: English
• Published: United States 01.02.2025
• Subjects: Adult; Aged; Antipsychotic Agents - administration & dosage; Antipsychotic Agents - pharmacokinetics; Antipsychotic Agents - therapeutic use; Aryldialkylphosphatase - blood; Aryldialkylphosphatase - metabolism; Cross-Sectional Studies; Drug Monitoring - methods; Female; Humans; Male; Middle Aged; Olanzapine - administration & dosage; Olanzapine - pharmacokinetics; Olanzapine - therapeutic use; Schizophrenia - blood; Schizophrenia - drug therapy; Young Adult; olanzapine; Therapeutic drug monitoring indicator; cardiometabolic risk; PON-1 activity; outcome responses

Therapeutic drug monitoring (TDM) indicators have been suggested to predict overall outcome responses to olanzapine (OLZ) treatments in terms of efficacy and metabolic syndrome. This study aimed to investigate whether paraoxonase-1 (PON-1) activity can be used to predict schizophrenia patient outcom...