Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity
Diabetes is a common chronic disease. Given the increasing incidence of diabetes, more individuals are affected by diabetic optic neuropathy (DON), which results in decreased vision. Whether DON leads to abnormalities of other visual systems, including the eye, the visual cortex, and other brain reg...
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| Published in | World journal of diabetes Vol. 12; no. 3; pp. 278 - 291 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Baishideng Publishing Group Inc
15.03.2021
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Diabetes is a common chronic disease. Given the increasing incidence of diabetes, more individuals are affected by diabetic optic neuropathy (DON), which results in decreased vision. Whether DON leads to abnormalities of other visual systems, including the eye, the visual cortex, and other brain regions, remains unknown.
To investigate the local characteristics of spontaneous brain activity using regional homogeneity (ReHo) in patients with DON.
We matched 22 patients with DON with 22 healthy controls (HCs). All subjects underwent resting-state functional magnetic resonance imaging. The ReHo technique was used to record spontaneous changes in brain activity. Receiver operating characteristic (ROC) curves were applied to differentiate between ReHo values for patients with DON and HCs. We also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation analysis.
ReHo values of the right middle frontal gyrus (RMFG), left anterior cingulate (LAC), and superior frontal gyrus (SFG)/left frontal superior orbital gyrus (LFSO) were significantly lower in DON patients compared to HCs. Among these, the greatest difference was observed in the RMFG. The result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON, and the RMFG and LAC ReHo values are more clinically relevant than SFG/LFSO. We also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values (
= -0.9336,
< 0.0001 and
= -0.8453,
< 0.0001, respectively).
Three different brain regions show ReHo changes in DON patients, and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Author contributions: Guo GY was involved in the data curation and writing of the original draft; Zhang LJ performed the data curation and formal analysis, and participated in the writing and editing of the manuscript; Li B was involved in the data curation, and writing, review, and editing of the manuscript; Liang RB took part in the data curation and supervision of the study; Ge QM was involved in the study conceptualization and methodology design; Shu HY was involved in data validation and visualization; Li QY participated in the methodology design and data visualization; Pan YC was involved in methodology design and data validation; Shao Y and Pei CG were involved in the study conceptualization, data curation, funding acquisition, and project administration; all authors have read and approved the final manuscript. Supported by National Natural Science Foundation of China, No. 81660158 and No. 81400372; Natural Science Research Foundation of Jiangxi Province, No. 20161ACB21017; and Medical Science Foundation of Jiangxi Province, No. 20181BBG70004 and No. 20164017. Corresponding author: Yi Shao, MD, Professor, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. freebee99@163.com |
| ISSN: | 1948-9358 1948-9358 |
| DOI: | 10.4239/wjd.v12.i3.278 |