Early and delayed onset of response to antidepressants in individual trajectories of change during treatment of major depression: a secondary analysis of data from the Genome-Based Therapeutic Drugs for Depression (GENDEP) study

• Published in: The journal of clinical psychiatry Vol. 72; no. 11; p. 1478
• Main Authors: Uher, Rudolf, Mors, Ole, Rietschel, Marcella, Rajewska-Rager, Aleksandra, Petrovic, Ana, Zobel, Astrid, Henigsberg, Neven, Mendlewicz, Julien, Aitchison, Katherine J, Farmer, Anne, McGuffin, Peter
• Format: Journal Article
• Language: English
• Published: United States 01.11.2011
• Subjects: Adult; Antidepressive Agents, Second-Generation - administration & dosage; Antidepressive Agents, Second-Generation - therapeutic use; Antidepressive Agents, Tricyclic - administration & dosage; Antidepressive Agents, Tricyclic - therapeutic use; Citalopram - administration & dosage; Citalopram - therapeutic use; Depressive Disorder, Major - drug therapy; Drug Administration Schedule; Female; Humans; Longitudinal Studies; Male; Middle Aged; Multicenter Studies as Topic; Nortriptyline - administration & dosage; Nortriptyline - therapeutic use; Prognosis; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome

The timing and rate of improvement after the initiation of an antidepressant has implications for establishing the mechanism of antidepressant action and for answering the clinically relevant question of how long an appropriate trial of antidepressant medication should be. We explore the individual...