Histologic, immunohistochemical, microbiological, molecular biological and ultrastructural characterization of pulmonary tularemia
Tularemia is a rare zoonotic disease caused by Francisella tularensis, a Gram-negative bacteria. The clinical manifestations of pulmonary tularemia resemble those of other airways infections. Recently, a case of pulmonary tularemia was diagnosed at Tufts Medical Center. The purpose of the current re...
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Published in | Pathology, research and practice Vol. 207; no. 1; pp. 63 - 66 |
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Abstract | Tularemia is a rare zoonotic disease caused by
Francisella tularensis, a Gram-negative bacteria. The clinical manifestations of pulmonary tularemia resemble those of other airways infections. Recently, a case of pulmonary tularemia was diagnosed at Tufts Medical Center. The purpose of the current report is to document the utility of applying several diagnostic tools, including immunohistochemistry, electron microscopy, microbiology and molecular biology in confirming the diagnosis of pulmonary tularemia, particularly in convalescing cases (up to 3 weeks postpresentation) and after antibiotic therapy. Our study demonstrates the usefulness of microbiological studies followed by morphological evaluation and the limitation of the molecular biology analysis of posttherapy samples. |
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AbstractList | Tularemia is a rare zoonotic disease caused by
Francisella tularensis, a Gram-negative bacteria. The clinical manifestations of pulmonary tularemia resemble those of other airways infections. Recently, a case of pulmonary tularemia was diagnosed at Tufts Medical Center. The purpose of the current report is to document the utility of applying several diagnostic tools, including immunohistochemistry, electron microscopy, microbiology and molecular biology in confirming the diagnosis of pulmonary tularemia, particularly in convalescing cases (up to 3 weeks postpresentation) and after antibiotic therapy. Our study demonstrates the usefulness of microbiological studies followed by morphological evaluation and the limitation of the molecular biology analysis of posttherapy samples. Tularemia is a rare zoonotic disease caused by Francisella tularensis, a Gram-negative bacteria. The clinical manifestations of pulmonary tularemia resemble those of other airways infections. Recently, a case of pulmonary tularemia was diagnosed at Tufts Medical Center. The purpose of the current report is to document the utility of applying several diagnostic tools, including immunohistochemistry, electron microscopy, microbiology and molecular biology in confirming the diagnosis of pulmonary tularemia, particularly in convalescing cases (up to 3 weeks postpresentation) and after antibiotic therapy. Our study demonstrates the usefulness of microbiological studies followed by morphological evaluation and the limitation of the molecular biology analysis of posttherapy samples. |
Author | Zoukhri, Driss Navarro, Paula Telford, Sam R. Alroy, Joseph McMahon, James H. Garcia-Moliner, Maria L. |
Author_xml | – sequence: 1 givenname: Paula surname: Navarro fullname: Navarro, Paula organization: Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA – sequence: 2 givenname: Maria L. surname: Garcia-Moliner fullname: Garcia-Moliner, Maria L. organization: Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA – sequence: 3 givenname: James H. surname: McMahon fullname: McMahon, James H. organization: Department of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA – sequence: 4 givenname: Sam R. surname: Telford fullname: Telford, Sam R. organization: Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, Grafton, MA, USA – sequence: 5 givenname: Driss surname: Zoukhri fullname: Zoukhri, Driss organization: Department of General Dentistry, Tufts University School of Dental Medicine, Boston, MA, USA – sequence: 6 givenname: Joseph surname: Alroy fullname: Alroy, Joseph email: joseph.alroy@tufts.edu organization: Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA |
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Sci. doi: 10.1196/annals.1409.013 contributor: fullname: Matyas |
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Snippet | Tularemia is a rare zoonotic disease caused by
Francisella tularensis, a Gram-negative bacteria. The clinical manifestations of pulmonary tularemia resemble... Tularemia is a rare zoonotic disease caused by Francisella tularensis, a Gram-negative bacteria. The clinical manifestations of pulmonary tularemia resemble... |
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SubjectTerms | Anti-Bacterial Agents - therapeutic use Antigens, Bacterial - analysis Drainage Francisella tularensis - genetics Francisella tularensis - immunology Francisella tularensis - pathogenicity Humans Immunohistochemistry Lung - diagnostic imaging Lung - microbiology Lung - pathology Lung - ultrastructure Lung Diseases - diagnosis Lung Diseases - drug therapy Lung Diseases - microbiology Lung Diseases - surgery Male Microbiology Microscopy, Electron Molecular biology Morphology Pleural Effusion - complications Pleural Effusion - therapy Polymerase Chain Reaction Tomography, X-Ray Computed Treatment Outcome Tularemia Tularemia - diagnosis Tularemia - drug therapy Tularemia - surgery Young Adult |
Title | Histologic, immunohistochemical, microbiological, molecular biological and ultrastructural characterization of pulmonary tularemia |
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