The Relationship Between Myocardial Infarction and Estrogen Use: A Literature Review

• Published in: Curēus (Palo Alto, CA) Vol. 15; no. 9; p. e46134
• Main Authors: Javed, Ayesha, Ravi, Phanish C, Bilal Delvi, Sarah, Faraz Hussain, Iqra, Acosta G., Arnaldo J, Iqbal, Warda, Krishnamaneni, Vamsi, Alasaadi, Saya, Pradhan, Swetapadma, Vashisht, Rishabh, Modi, Shivani
• Format: Journal Article
• Language: English
• Published: Palo Alto Cureus Inc 28.09.2023; Cureus
• Subjects: Cardiovascular disease; Estrogens; Health risks; Heart attacks; Hormone replacement therapy; Internal Medicine; Menopause; Mortality; Obstetrics/Gynecology; Older people; Other; Womens health
• DOI: 10.7759/cureus.46134
• ISSN: 2168-8184

This thorough literature evaluation was prompted by significant research into the complex interactions between estrogen use and myocardial infarction (MI). Estrogen has fascinated researchers because of its possible cardioprotective benefits and its impact on cardiovascular health. In order to clarify the connection between estrogen use and the risk of MI, this review critically examines the body of prior evidence.This review focuses on estrogen and its pivotal role in cardiovascular health, concentrating on lipid metabolism, vasodilation, inflammation, and endothelial function. It examines contentious data about estrogen therapy's heart-protective effects, taking into account age, initiation timing, dosage, and dosage of administration. Genetic and epigenetic influences on MI risk among estrogen users highlight intricate, personalized estrogen effects.The conclusion summarizes the main findings and emphasizes the need for an all-encompassing strategy for initiating and managing estrogen medication. It is crucial to consider patient-specific traits and risk factors to successfully customize treatment regimens. This review sheds vital light on the potential directions for better cardiovascular treatment for postmenopausal women by shedding light on the complex link between estrogen use and myocardial infarction. The review also identifies research gaps and future objectives in this area, highlighting the demand for novel medicines and individualized strategies to improve cardiovascular outcomes.