Endothelial Nitric Oxide Synthase Genotype and Ischemic Heart Disease Meta-Analysis of 26 Studies Involving 23028 Subjects

• Published in: Circulation (New York, N.Y.) Vol. 109; no. 11; pp. 1359 - 1365
• Main Authors: Casas, Juan P., Bautista, Leonelo E., Humphries, Steve E., Hingorani, Aroon D.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 23.03.2004
• Subjects: Adult; Aged; Alleles; Amino Acid Substitution; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Case-Control Studies; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Genetic Predisposition to Disease; Genotype; Humans; Introns - genetics; Male; Medical sciences; Middle Aged; Myocardial Infarction - enzymology; Myocardial Infarction - epidemiology; Myocardial Infarction - genetics; Myocardial Ischemia - enzymology; Myocardial Ischemia - epidemiology; Myocardial Ischemia - genetics; Nitric Oxide Synthase - genetics; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Risk; Risk Factors; Human; Myocardial infarction; Nervous system diseases; Enzyme; Cardiovascular disease; Genotype; Myocardial disease; Nitric-oxide synthase; Vascular disease; Ischemia; Heart disease; Oxidoreductases; Polymorphism

Background— Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of ischemic heart disease (IHD), but data from published studies with individually low statistical power are conflicting. To evaluate the role of polymorphisms in the eNOS gene in IHD, we considered...