Synaptic Pruning by Microglia: Lessons from Genetic Studies in Mice

• Published in: Developmental neuroscience p. 1
• Main Authors: de Deus, Junia Lara, Faborode, Oluwaseun Samuel, Nandi, Sayan
• Format: Journal Article
• Language: English
• Published: Switzerland 12.09.2024
• Subjects: Synapse engulfment; Behavior; Excitatory and inhibitory synapses; Phagocytosis; Microglia

Neural circuits are subjected to refinement throughout life. The dynamic addition and elimination (pruning) of synapses are necessary for maturation of neural circuits and synaptic plasticity. Due to their phagocytic nature, microglia have been considered as the primary mediators of synaptic pruning...