Towards New Delivery Agents for Boron Neutron Capture Therapy: Synthesis and In Vitro Evaluation of a Set of Fluorinated Carbohydrate Derivatives

Boron Neutron Capture Therapy (BNCT) is a cancer treatment which combines tumor-selective boron delivery agents with thermal neutrons in order to selectively eradicate cancer cells. In this work, we focus on the early-stage development of carbohydrate delivery agents for BNCT. In more detail, we exp...

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Published inMolecules (Basel, Switzerland) Vol. 29; no. 17; p. 4263
Main Authors Matović, Jelena, Järvinen, Juulia, Sokka, Iris K, Imlimthan, Surachet, Aitio, Olli, Sarparanta, Mirkka, Rautio, Jarkko, Ekholm, Filip S
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 09.09.2024
Subjects
Acids
Boron
Boron - chemistry
boron neutron capture therapy
Boron Neutron Capture Therapy - methods
cancer therapeutics
Cancer therapies
Carbohydrates
Carbohydrates - chemistry
Cell Line, Tumor
Chemical synthesis
Drug Delivery Systems
Glucose
Halogenation
Head & neck cancer
Humans
Libraries
Neoplasms - drug therapy
Neoplasms - radiotherapy
Neutrons
preclinical profiling
structural elucidation
carbohydrates
chemical synthesis
cancer therapeutics
preclinical profiling
structural elucidation
boron neutron capture therapy
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Abstract Boron Neutron Capture Therapy (BNCT) is a cancer treatment which combines tumor-selective boron delivery agents with thermal neutrons in order to selectively eradicate cancer cells. In this work, we focus on the early-stage development of carbohydrate delivery agents for BNCT. In more detail, we expand upon our previous GLUT-targeting approach by synthesizing and evaluating the potential embedded in a representative set of fluorinated carbohydrates bearing a boron cluster. Our findings indicate that these species may have advantages over the boron delivery agents in current clinical use, e.g., significantly improved boron delivery capacity at the cellular level. Simultaneously, the carbohydrate delivery agents were found to bind strongly to plasma proteins, which may be a concern requiring further action before progression to in vivo studies. Altogether, this work brings new insights into factors which need to be accounted for if attempting to develop theranostic agents for BNCT based on carbohydrates in the future.
AbstractList Boron Neutron Capture Therapy (BNCT) is a cancer treatment which combines tumor-selective boron delivery agents with thermal neutrons in order to selectively eradicate cancer cells. In this work, we focus on the early-stage development of carbohydrate delivery agents for BNCT. In more detail, we expand upon our previous GLUT-targeting approach by synthesizing and evaluating the potential embedded in a representative set of fluorinated carbohydrates bearing a boron cluster. Our findings indicate that these species may have advantages over the boron delivery agents in current clinical use, e.g., significantly improved boron delivery capacity at the cellular level. Simultaneously, the carbohydrate delivery agents were found to bind strongly to plasma proteins, which may be a concern requiring further action before progression to in vivo studies. Altogether, this work brings new insights into factors which need to be accounted for if attempting to develop theranostic agents for BNCT based on carbohydrates in the future.
Boron Neutron Capture Therapy (BNCT) is a cancer treatment which combines tumor-selective boron delivery agents with thermal neutrons in order to selectively eradicate cancer cells. In this work, we focus on the early-stage development of carbohydrate delivery agents for BNCT. In more detail, we expand upon our previous GLUT-targeting approach by synthesizing and evaluating the potential embedded in a representative set of fluorinated carbohydrates bearing a boron cluster. Our findings indicate that these species may have advantages over the boron delivery agents in current clinical use, e.g., significantly improved boron delivery capacity at the cellular level. Simultaneously, the carbohydrate delivery agents were found to bind strongly to plasma proteins, which may be a concern requiring further action before progression to in vivo studies. Altogether, this work brings new insights into factors which need to be accounted for if attempting to develop theranostic agents for BNCT based on carbohydrates in the future.Boron Neutron Capture Therapy (BNCT) is a cancer treatment which combines tumor-selective boron delivery agents with thermal neutrons in order to selectively eradicate cancer cells. In this work, we focus on the early-stage development of carbohydrate delivery agents for BNCT. In more detail, we expand upon our previous GLUT-targeting approach by synthesizing and evaluating the potential embedded in a representative set of fluorinated carbohydrates bearing a boron cluster. Our findings indicate that these species may have advantages over the boron delivery agents in current clinical use, e.g., significantly improved boron delivery capacity at the cellular level. Simultaneously, the carbohydrate delivery agents were found to bind strongly to plasma proteins, which may be a concern requiring further action before progression to in vivo studies. Altogether, this work brings new insights into factors which need to be accounted for if attempting to develop theranostic agents for BNCT based on carbohydrates in the future.
Author Sarparanta, Mirkka
Järvinen, Juulia
Ekholm, Filip S
Imlimthan, Surachet
Rautio, Jarkko
Matović, Jelena
Sokka, Iris K
Aitio, Olli
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Snippet Boron Neutron Capture Therapy (BNCT) is a cancer treatment which combines tumor-selective boron delivery agents with thermal neutrons in order to selectively...
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StartPage 4263
SubjectTerms Acids
Boron
Boron - chemistry
boron neutron capture therapy
Boron Neutron Capture Therapy - methods
cancer therapeutics
Cancer therapies
Carbohydrates
Carbohydrates - chemistry
Cell Line, Tumor
Chemical synthesis
Drug Delivery Systems
Glucose
Halogenation
Head & neck cancer
Humans
Libraries
Neoplasms - drug therapy
Neoplasms - radiotherapy
Neutrons
preclinical profiling
structural elucidation
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Title Towards New Delivery Agents for Boron Neutron Capture Therapy: Synthesis and In Vitro Evaluation of a Set of Fluorinated Carbohydrate Derivatives
URI https://www.ncbi.nlm.nih.gov/pubmed/39275111
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Volume 29
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