LL-Z1272 alpha epoxide, a precursor of ascochlorin produced by a mutant of Ascochyta viciae

• Published in: Journal of antibiotics Vol. 62; no. 10; pp. 571 - 574
• Main Authors: Hosono, Kuniaki, Ogihara, Jun, Ohdake, Takamichi, Masuda, Setsuko
• Format: Journal Article
• Language: English
• Published: TOKYO Japan Antibiotics Research Assoc 01.10.2009
• Subjects: Biotechnology & Applied Microbiology; Immunology; Life Sciences & Biomedicine; Microbiology; Pharmacology & Pharmacy; Science & Technology; fungal metabolite; ANTIBIOTICS; METABOLITES; prenylphenol antibiotic; ASCOFURANONE; PROPERTY; RATS; MICE; CYLINDROCLADIUM; ascochlorin precursor; LL-Z1272 alpha epoxide; ANTITUMOR

A novel metabolite, LL-Z1272 alpha epoxide, structurally related to ascochlorin, was isolated from the cultured mycelium of Ascochyta viciae J-29, a mutant derived from A. viciae Libert. The structure was elucidated on the basis of spectroscopic data. The epoxide is proposed to be enzymatically form...