Post-transcriptional regulation of insulin-like growth factor binding protein-2 mRNA in diabetic rat liver
IGFBP-1 and IGFBP-2 mRNAs are increased in the livers of streptozotocin-diabetic rats. A corresponding increase is observed in transcription of the IGFBP-1 but not the IGFBP-2 gene, indicating that the increase in steady-state levels of IGFBP-2 mRNA is a post-transcriptional effect. IGFBP-1 and IGFB...
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| Published in | Biochemical and biophysical research communications Vol. 189; no. 2; pp. 1031 - 1037 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
San Diego, CA
Elsevier Inc
15.12.1992
Elsevier |
| Subjects | |
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| Abstract | IGFBP-1 and IGFBP-2 mRNAs are increased in the livers of streptozotocin-diabetic rats. A corresponding increase is observed in transcription of the IGFBP-1 but not the IGFBP-2 gene, indicating that the increase in steady-state levels of IGFBP-2 mRNA is a post-transcriptional effect. IGFBP-1 and IGFBP-2 mRNAs also differ in the rapidity of their response to insulin treatment: hepatic IGFBP-1 mRNA is normalized within 1 h, IGFBP-2 mRNA decreases more slowly. These differences suggest that IGFBP-2 may provide more chronic adaptation to metabolic change than IGFBP-1. |
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| AbstractList | IGFBP-1 and IGFBP-2 mRNAs are increased in the livers of streptozotocin-diabetic rats. A corresponding increase is observed in transcription of the IGFBP-1 but not the IGFBP-2 gene, indicating that the increase in steady-state levels of IGFBP-2 mRNA is a post-transcriptional effect. IGFBP-1 and IGFBP-2 mRNAs also differ in the rapidity of their response to insulin treatment: hepatic IGFBP-1 mRNA is normalized within 1 h, IGFBP-2 mRNA decreases more slowly. These differences suggest that IGFBP-2 may provide more chronic adaptation to metabolic change than IGFBP-1 IGFBP-1 and IGFBP-2 mRNAs are increased in the livers of streptozotocin-diabetic rats. A corresponding increase is observed in transcription of the IGFBP-1 but not the IGFBP-2 gene, indicating that the increase in steady-state levels of IGFBP-2 mRNA is a post-transcriptional effect. IGFBP-1 and IGFBP-2 mRNAs also differ in the rapidity of their response to insulin treatment: hepatic IGFBP-1 mRNA is normalized within 1 h, IGFBP-2 mRNA decreases more slowly. These differences suggest that IGFBP-2 may provide more chronic adaptation to metabolic change than IGFBP-1. |
| Author | Ooi, Guck T. Y.-H. Tseng, Lucy Rechler, Matthew M. |
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| Cites_doi | 10.1016/S0021-9258(18)42289-2 10.1172/JCI114797 10.1016/S0021-9258(18)55228-5 10.1016/0014-5793(89)81465-6 10.1210/endo-128-2-689 10.1016/0303-7207(89)90096-8 10.1210/mend-4-8-1199 10.1016/S0021-9258(18)69282-8 10.1016/S0021-9258(18)83711-5 10.2337/diab.41.4.499 10.1016/0003-2697(87)90021-2 10.1016/0003-9861(91)90173-G 10.1210/endo-126-1-644 10.1210/mend-3-7-1053 10.1016/S0021-9258(18)61603-5 10.1007/BF00229592 10.1210/mend-4-2-321 10.1210/jcem-73-4-727 |
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| Keywords | Endocrinopathy Rat Diabetes mellitus Liver Rodentia Insulin like growth factor 2 Insulin Posttranscriptional modification Protein hormone Binding protein Vertebrata Chronic Mammalia Polypeptide Kinetics Growth factor |
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| SubjectTerms | Analytical, structural and metabolic biochemistry Animals ARN MENSAJERO ARN MESSAGER Binding and carrier proteins Biological and medical sciences Blotting, Northern Carrier Proteins - biosynthesis Carrier Proteins - genetics Cell Nucleus - physiology DIABETE DIABETES Diabetes Mellitus, Experimental - metabolism EXPERIMENTATION EXPERIMENTOS FOIE Fundamental and applied biological sciences. Psychology GENE GENES HIGADO Insulin - pharmacology Insulin, Isophane - pharmacology Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Protein 2 INSULINA INSULINE Kinetics Liver - drug effects Liver - metabolism Male PROTEINAS PROTEINE Proteins RAT RATA Rats Rats, Sprague-Dawley RNA Processing, Post-Transcriptional RNA, Messenger - genetics RNA, Messenger - metabolism Somatomedins - metabolism Transcription, Genetic - drug effects |
| Title | Post-transcriptional regulation of insulin-like growth factor binding protein-2 mRNA in diabetic rat liver |
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