Post-transcriptional regulation of insulin-like growth factor binding protein-2 mRNA in diabetic rat liver

IGFBP-1 and IGFBP-2 mRNAs are increased in the livers of streptozotocin-diabetic rats. A corresponding increase is observed in transcription of the IGFBP-1 but not the IGFBP-2 gene, indicating that the increase in steady-state levels of IGFBP-2 mRNA is a post-transcriptional effect. IGFBP-1 and IGFB...

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Published inBiochemical and biophysical research communications Vol. 189; no. 2; pp. 1031 - 1037
Main Authors Ooi, Guck T., Y.-H. Tseng, Lucy, Rechler, Matthew M.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 15.12.1992
Elsevier
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Summary:IGFBP-1 and IGFBP-2 mRNAs are increased in the livers of streptozotocin-diabetic rats. A corresponding increase is observed in transcription of the IGFBP-1 but not the IGFBP-2 gene, indicating that the increase in steady-state levels of IGFBP-2 mRNA is a post-transcriptional effect. IGFBP-1 and IGFBP-2 mRNAs also differ in the rapidity of their response to insulin treatment: hepatic IGFBP-1 mRNA is normalized within 1 h, IGFBP-2 mRNA decreases more slowly. These differences suggest that IGFBP-2 may provide more chronic adaptation to metabolic change than IGFBP-1.
Bibliography:9324546
S30
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(92)92307-J