Poly(N-isopropyl acrylamide)-coated surfaces: Investigation of the mechanism of cell detachment

• Published in: Biointerphases Vol. 12; no. 2; p. 02C401
• Main Authors: Cooperstein, Marta A, Nguyen, Phuong A H, Canavan, Heather E
• Format: Journal Article
• Language: English
• Published: United States 01.06.2017
• Subjects: Acrylic Resins - pharmacology; Animals; Aorta - cytology; Cattle; Cell Adhesion - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Cells, Cultured; Coated Materials, Biocompatible - pharmacology; Endothelial Cells - cytology; Endothelial Cells - drug effects; Microscopy, Fluorescence; Sodium Azide - pharmacology; Surface Properties; Temperature

Although there is a great deal of research focused on cell sheet engineering from polymers such as poly(N-isopropyl acrylamide) (pNIPAM), the biocompatibility of pNIPAM surfaces and the nature of cellular detachment from this polymer is still unclear. The most extensive study of the mechanism of det...