Macrolides mediate transcriptional activation of the msr(E)-mph(E) operon through histone-like nucleoid-structuring protein (HNS) and cAMP receptor protein (CRP)

• Published in: Journal of antimicrobial chemotherapy Vol. 77; no. 2; pp. 391 - 399
• Main Authors: Duan, Yitao, Liu, Shuangqing, Gao, Yuting, Zhang, Peng, Mao, Daqing, Luo, Yi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 02.02.2022
• Subjects: Anti-Bacterial Agents - pharmacology; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Cyclic AMP Receptor Protein - genetics; Cyclic AMP Receptor Protein - metabolism; DNA-Binding Proteins; Drug Resistance, Bacterial - genetics; Escherichia coli - genetics; Escherichia coli Proteins; Histones - genetics; Histones - metabolism; Humans; Klebsiella pneumoniae - genetics; Macrolides - pharmacology; Operon; Transcriptional Activation

Abstract Objectives The msr(E)-mph(E) operon exists widely in diverse species of bacteria and msr(E) and mph(E) genes confer high resistance to macrolides. We aimed to explore whether macrolides regulate the transcription of the operon. Methods Antibiotic resistance genes in clinical isolates of Kle...