Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-β/RUNX axis

• Published in: Science advances Vol. 1; no. 8; p. e1500296
• Main Authors: Anderson, Brett D, Harris, Reuben S
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 01.09.2015
• Subjects: Immunology; SciAdv r-articles; HIV-1; Vif; CBF-β; innate immunity; Host-Pathogen interaction; APOBEC3 restriction factors; HIV-1 pathogenesis; RUNX; antiviral state; lentivirus

A diverse set of innate immune mechanisms protects cells from viral infections. The APOBEC3 family of DNA cytosine deaminases is an integral part of these defenses. For instance, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H would have the potential to destroy HIV-1 complementary DNA replication interm...