A 3D Cell Culture Platform for Evaluating Macrophage‐Liposome Conjugates in Combination Chemotherapy

• Published in: Journal of biomedical materials research. Part A Vol. 113; no. 6; pp. e37939 - n/a
• Main Authors: Kuo, Chia‐Chen, Liao, Wei‐Yu, Lin, Yu‐Jung, Lee, Chau‐Hwang
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.06.2025; Wiley Subscription Services, Inc
• Subjects: 3D cell culture; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Cell culture; Cell Culture Techniques, Three Dimensional - methods; Cell Line, Tumor; Cell migration; Chemotherapy; Cisplatin; Cisplatin - administration & dosage; Cisplatin - pharmacology; combination chemotherapy; Conjugates; Design optimization; Dosage; Drug delivery; Drug Delivery Systems; Drug dosages; Homing behavior; Humans; liposome; Liposomes; Liposomes - chemistry; macrophage; Macrophages; Macrophages - cytology; Macrophages - metabolism; Mice; Paclitaxel; Paclitaxel - administration & dosage; Paclitaxel - pharmacology; Solid tumors; Tumors; 3D cell culture; macrophage; liposome; combination chemotherapy

ABSTRACT Macrophage‐based drug delivery systems, such as macrophage‐liposome conjugates (Mϕ‐Lip), leverage the natural tumor‐homing ability of macrophages and offer a potential solution for overcoming biological barriers and delivering chemotherapy drugs to challenging tumor regions. However, reliab...