9‐Ethynyl noscapine induces G2/M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer

• Published in: Drug development research Vol. 83; no. 3; pp. 605 - 614
• Main Authors: Nagireddy, Praveen Kumar Reddy, Kumar, Dinesh, Kommalapati, Vamsi Krishna, Pedapati, Ravi Kumar, Kojja, Venkateswarlu, Tangutur, Anjana Devi, Kantevari, Srinivas
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2022
• Subjects: Analogs; Anticancer properties; Antitumor activity; Apoptosis; Biological activity; Breast cancer; Caspase-3; Cell cycle; Cell viability; Cervical cancer; Cervix; Cytochrome; Cytochrome c; Cytochromes; Disruption; Functional groups; Latex; noscapine; Polymerization; Prostate cancer; Tubulin; Tumor cell lines; Western blotting; noscapine; apoptosis; cervical cancer

Noscapine is a phthalide isoquinoline alkaloid present in the latex of Papaver somniferum and has demonstrated potent antitumor activity in various cancer models. Structural changes in the core molecule of noscapine architecture have produced a number of potent analogs. We have recently synthesized...