The test-negative design: validity, accuracy and precision of vaccine efficacy estimates compared to the gold standard of randomised placebo-controlled clinical trials

• Published in: Euro surveillance : bulletin européen sur les maladies transmissibles Vol. 18; no. 37; p. 1
• Main Authors: De Serres, G, Skowronski, D M, Wu, X W, Ambrose, C S
• Format: Journal Article
• Language: English
• Published: Sweden Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) 12.09.2013
• Subjects: Case-Control Studies; Child, Preschool; Clinical trials; Comparative analysis; Disease prevention; Female; Humans; Infant; Influenza Vaccines - administration & dosage; Influenza, Human - prevention & control; Influenza, Human - virology; Intervention; Male; Monoclonal antibodies; Randomized Controlled Trials as Topic; Reproducibility of Results; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - prevention & control; Respiratory Syncytial Virus Infections - virology; Respiratory Syncytial Viruses; Vaccines; Vaccines, Attenuated - administration & dosage

The test-negative design (TND) is an efficient form of case-control study commonly applied to influenza vaccine effectiveness (VE) estimation. TND validity is predicated on the core assumption that the intervention (vaccine) has no effect on other non-targeted aetiologies resulting in similar illnes...