Melatonin, a potentially effective drug for the treatment of infected bone nonunion

• Published in: Journal of pineal research Vol. 76; no. 1; pp. e12914 - n/a
• Main Authors: Qin, Han‐jun, He, Si‐ying, Shen, Ke, Lin, Qing‐rong, Hu, Yan‐jun, Chen, Zi‐lin, Yu, Bin, Jiang, Nan
• Format: Journal Article
• Language: English
• Published: England 01.01.2024
• Subjects: bone nonunion; ferroptosis; Humans; melatonin; Melatonin - pharmacology; Melatonin - therapeutic use; Nox4; Osteoblasts; Osteogenesis; osteomyelitis; Osteomyelitis - drug therapy; Staphylococcus aureus; osteomyelitis; Nox4; ferroptosis; melatonin; bone nonunion

Osteomyelitis (OM), characterized by heterogeneity and complexity in treatment, has a high risk of infection recurrence which may cause limb disability. Management of chronic inactive osteomyelitis (CIOM) without typical inflammatory symptoms is a great challenge for orthopedic surgeons. On the basi...