Antiretroviral therapy in HIV‐1‐infected individuals with CD4 count below 100 cells/mm3 results in differential recovery of monocyte activation

• Published in: Journal of leukocyte biology Vol. 100; no. 1; pp. 223 - 231
• Main Authors: Patro, Sean C., Azzoni, Livio, Joseph, Jocelin, Fair, Matthew G., Sierra‐Madero, Juan G., Rassool, Mohammed S., Sanne, Ian, Montaner, Luis J.
• Format: Journal Article
• Language: English
• Published: United States Society for Leukocyte Biology 01.07.2016
• Subjects: activation resolution; Adult; AIDS; Antiretroviral Therapy, Highly Active; Biomarkers - metabolism; CCR5 Receptor Antagonists - pharmacology; CD4 Lymphocyte Count; Cyclohexanes - pharmacology; Female; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - metabolism; HIV Infections - virology; HIV-1 - immunology; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Leukocytes, Mononuclear - virology; Lymphocyte Activation; macrophage; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Macrophages - virology; Male; Middle Aged; Monocytes - drug effects; Monocytes - immunology; Monocytes - metabolism; Monocytes - virology; pathogenesis; Translational & Clinical Immunology; Triazoles - pharmacology; Viral Load - drug effects; Viral Load - immunology; activation resolution; pathogenesis; AIDS; macrophage

In advanced HIV‐1 disease, 24 weeks of ART‐mediated recovery results in reversal of activated cell‐specific monocyte subsets, with minimal recovery of soluble makers of tissue‐associated myeloid activation. Reversal of monocyte and macrophage activation and the relationship to viral suppression and...