Development, Validation and Application of RP-HPLC Method: Simultaneous Determination of Antihistamine and Preservatives with Paracetamol in Liquid Formulations and Human Serum

• Published in: The open medicinal chemistry journal Vol. 10; no. 1; pp. 33 - 43
• Main Authors: Hasan, Najmul, Chaiharn, Mathurot, Toor, Umair Ali, Mirani, Zulfiqar Ali, Sajjad, Ghulam, Sher, Nawab, Aziz, Mubashir, Siddiqui, Farhan Ahmed
• Format: Journal Article
• Language: English
• Published: United Arab Emirates Bentham Open 31.08.2016
• Subjects: RP-HPLC; Oral solution; Paracetamol; Preservatives; Cetirizine HCl; Paraben

In this article we describe development and validation of stability indicating, accurate, specific, precise and simple Ion-pairing RP-HPLC method for simultaneous determination of paracetamol and cetirizine HCl along with preservatives i.e. propylparaben, and methylparaben in pharmaceutical dosage f...