Pharmacokinetic and pharmacodynamic interaction of DWP16001, a sodium–glucose cotransporter 2 inhibitor, with gemigliptin and metformin in healthy adults

• Published in: British journal of clinical pharmacology Vol. 89; no. 6; pp. 1780 - 1788
• Main Authors: Jeong, Sae Im, Kim, Yun, Nah, Jae Jin, Huh, Wan, Jang, In‐Jin, Hwang, Jun Gi, Lee, SeungHwan
• Format: Journal Article
• Language: English
• Published: England 01.06.2023
• Subjects: Adult; Area Under Curve; Benzofurans - pharmacokinetics; Benzofurans - pharmacology; Cross-Over Studies; diabetes; Diabetes Mellitus, Type 2 - drug therapy; Drug Interactions; Glucose; Healthy Volunteers; Humans; Hypoglycemic Agents; Male; Metformin; pharmacodynamics; pharmacokinetics; Sodium; Sodium-Glucose Transporter 2 Inhibitors - pharmacology; pharmacokinetics; drug interactions; diabetes; pharmacodynamics

Aims DWP16001, a novel sodium–glucose cotransporter 2 inhibitor, is under clinical development for the treatment of type 2 diabetes mellitus. This study aimed to explore the pharmacokinetics (PK) and pharmacodynamics interaction of DWP16001 with gemigliptin and metformin. Methods A randomized, open‐...