Unrelated bone marrow transplant for congenital amegakaryocytic thrombocytopenia: Report of two cases and review of the literature
Frangoul H, Keates‐Baleeiro J, Calder C, Manes B, Crossno C, Castaneda VL, Domm J. Unrelated bone marrow transplant for congenital amegakaryocytic thrombocytopenia: Report of two cases and review of the literature. Pediatr Transplantation 2010: 14:E42–E45. © 2009 John Wiley & Sons A/S. : CAMT i...
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| Published in | Pediatric transplantation Vol. 14; no. 4; pp. E42 - E45 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.06.2010
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| Online Access | Get full text |
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| Abstract | Frangoul H, Keates‐Baleeiro J, Calder C, Manes B, Crossno C, Castaneda VL, Domm J. Unrelated bone marrow transplant for congenital amegakaryocytic thrombocytopenia: Report of two cases and review of the literature.
Pediatr Transplantation 2010: 14:E42–E45. © 2009 John Wiley & Sons A/S.
: CAMT is a very rare cause of thrombocytopenia in infants. Most of the patients will progress to marrow failure. Allogeneic stem cell transplant remains the only curative therapy. We present two patients with CAMT who underwent an unrelated donor bone marrow transplant, one after developing marrow failure and another early in the course of the disease. Both patients tolerated the transplant with minimal toxicity and durable engraftment. We also present a comprehensive review of the literature for unrelated donor transplant for this condition. |
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| AbstractList | CAMT is a very rare cause of thrombocytopenia in infants. Most of the patients will progress to marrow failure. Allogeneic stem cell transplant remains the only curative therapy. We present two patients with CAMT who underwent an unrelated donor bone marrow transplant, one after developing marrow failure and another early in the course of the disease. Both patients tolerated the transplant with minimal toxicity and durable engraftment. We also present a comprehensive review of the literature for unrelated donor transplant for this condition. Frangoul H, Keates‐Baleeiro J, Calder C, Manes B, Crossno C, Castaneda VL, Domm J. Unrelated bone marrow transplant for congenital amegakaryocytic thrombocytopenia: Report of two cases and review of the literature. Pediatr Transplantation 2010: 14:E42–E45. © 2009 John Wiley & Sons A/S. : CAMT is a very rare cause of thrombocytopenia in infants. Most of the patients will progress to marrow failure. Allogeneic stem cell transplant remains the only curative therapy. We present two patients with CAMT who underwent an unrelated donor bone marrow transplant, one after developing marrow failure and another early in the course of the disease. Both patients tolerated the transplant with minimal toxicity and durable engraftment. We also present a comprehensive review of the literature for unrelated donor transplant for this condition. |
| Author | Keates‐Baleeiro, Jennifer Castaneda, Victoria L. Manes, Becky Crossno, Christine Frangoul, Haydar Calder, Cassie Domm, Jennifer |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19490489$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Bone Marrow Transplantation - adverse effects congenital amegakaryocytic thrombocytopenia Female Humans Infant Megakaryocytes pediatrics Thrombocytopenia - congenital Thrombocytopenia - therapy unrelated donor bone marrow transplantation |
| Title | Unrelated bone marrow transplant for congenital amegakaryocytic thrombocytopenia: Report of two cases and review of the literature |
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