Exercise Improves Myocardial Deformation But Not Cardiac Structure in Preterm-Born Adults
People born preterm (<37 weeks' gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation. The authors investigated whether preterm-born and term-born adults exhibit similar cardiac structural and functional remodeling following a 16-week aerobic e...
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| Published in | JACC. Advances (Online) Vol. 4; no. 5; p. 101721 |
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| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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01.05.2025
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| Abstract | People born preterm (<37 weeks' gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation.
The authors investigated whether preterm-born and term-born adults exhibit similar cardiac structural and functional remodeling following a 16-week aerobic exercise intervention.
We conducted a randomized controlled trial in 203 adults (aged 18-35 years) with elevated blood pressure or stage 1 hypertension. Participants were randomized 1:1 to a 16-week aerobic exercise intervention or to a control group. In a prespecified cardiovascular magnetic resonance imaging (CMR) substudy, CMR was performed at 3.0-Tesla to assess left and right ventricular (LV and RV) structure and function before and after intervention.
A total of 100 participants completed CMR scans at baseline and after the 16-week intervention, with n = 47 in the exercise intervention group (n = 26 term-born; n = 21 preterm-born) and n = 53 controls (n = 32 term-born; n = 21 preterm-born). In term-born participants, LV mass to end-diastolic volume ratio decreased (−3.43; 95% CI: −6.29 to −0.56; interaction P = 0.027) and RV stroke volume index increased (5.53 mL/m2; 95% CI: 2.60, 8.47; interaction P = 0.076) for those in the exercise intervention group vs controls. No significant effects were observed for cardiac structural indices in preterm-born participants. In preterm-born participants, LV basal- and mid-ventricular circumferential strain increased (−1.33; 95% CI: −2.07 to −0.60; interaction P = 0.057 and −1.54; 95% CI: −2.46 to −0.63; interaction P = 0.046, respectively) and RV global longitudinal strain increased (1.99%; 95% CI: −3.12 to −0.87; interaction P = 0.053) in the exercise intervention group vs controls. No significant effects were observed for myocardial deformation parameters in term-born participants.
Aerobic exercise training induces improved myocardial function but not cardiac structure in preterm-born adults.
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| AbstractList | Background: People born preterm (<37 weeks' gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation. Objectives: The authors investigated whether preterm-born and term-born adults exhibit similar cardiac structural and functional remodeling following a 16-week aerobic exercise intervention. Methods: We conducted a randomized controlled trial in 203 adults (aged 18-35 years) with elevated blood pressure or stage 1 hypertension. Participants were randomized 1:1 to a 16-week aerobic exercise intervention or to a control group. In a prespecified cardiovascular magnetic resonance imaging (CMR) substudy, CMR was performed at 3.0-Tesla to assess left and right ventricular (LV and RV) structure and function before and after intervention. Results: A total of 100 participants completed CMR scans at baseline and after the 16-week intervention, with n = 47 in the exercise intervention group (n = 26 term-born; n = 21 preterm-born) and n = 53 controls (n = 32 term-born; n = 21 preterm-born). In term-born participants, LV mass to end-diastolic volume ratio decreased (−3.43; 95% CI: −6.29 to −0.56; interaction P = 0.027) and RV stroke volume index increased (5.53 mL/m2; 95% CI: 2.60, 8.47; interaction P = 0.076) for those in the exercise intervention group vs controls. No significant effects were observed for cardiac structural indices in preterm-born participants. In preterm-born participants, LV basal- and mid-ventricular circumferential strain increased (−1.33; 95% CI: −2.07 to −0.60; interaction P = 0.057 and −1.54; 95% CI: −2.46 to −0.63; interaction P = 0.046, respectively) and RV global longitudinal strain increased (1.99%; 95% CI: −3.12 to −0.87; interaction P = 0.053) in the exercise intervention group vs controls. No significant effects were observed for myocardial deformation parameters in term-born participants. Conclusions: Aerobic exercise training induces improved myocardial function but not cardiac structure in preterm-born adults. AbstractBackgroundPeople born preterm (<37 weeks' gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation. ObjectivesThe authors investigated whether preterm-born and term-born adults exhibit similar cardiac structural and functional remodeling following a 16-week aerobic exercise intervention. MethodsWe conducted a randomized controlled trial in 203 adults (aged 18-35 years) with elevated blood pressure or stage 1 hypertension. Participants were randomized 1:1 to a 16-week aerobic exercise intervention or to a control group. In a prespecified cardiovascular magnetic resonance imaging (CMR) substudy, CMR was performed at 3.0-Tesla to assess left and right ventricular (LV and RV) structure and function before and after intervention. ResultsA total of 100 participants completed CMR scans at baseline and after the 16-week intervention, with n = 47 in the exercise intervention group (n = 26 term-born; n = 21 preterm-born) and n = 53 controls (n = 32 term-born; n = 21 preterm-born). In term-born participants, LV mass to end-diastolic volume ratio decreased (−3.43; 95% CI: −6.29 to −0.56; interaction P = 0.027) and RV stroke volume index increased (5.53 mL/m 2; 95% CI: 2.60, 8.47; interaction P = 0.076) for those in the exercise intervention group vs controls. No significant effects were observed for cardiac structural indices in preterm-born participants. In preterm-born participants, LV basal- and mid-ventricular circumferential strain increased (−1.33; 95% CI: −2.07 to −0.60; interaction P = 0.057 and −1.54; 95% CI: −2.46 to −0.63; interaction P = 0.046, respectively) and RV global longitudinal strain increased (1.99%; 95% CI: −3.12 to −0.87; interaction P = 0.053) in the exercise intervention group vs controls. No significant effects were observed for myocardial deformation parameters in term-born participants. ConclusionsAerobic exercise training induces improved myocardial function but not cardiac structure in preterm-born adults. People born preterm (<37 weeks' gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation. The authors investigated whether preterm-born and term-born adults exhibit similar cardiac structural and functional remodeling following a 16-week aerobic exercise intervention. We conducted a randomized controlled trial in 203 adults (aged 18-35 years) with elevated blood pressure or stage 1 hypertension. Participants were randomized 1:1 to a 16-week aerobic exercise intervention or to a control group. In a prespecified cardiovascular magnetic resonance imaging (CMR) substudy, CMR was performed at 3.0-Tesla to assess left and right ventricular (LV and RV) structure and function before and after intervention. A total of 100 participants completed CMR scans at baseline and after the 16-week intervention, with n = 47 in the exercise intervention group (n = 26 term-born; n = 21 preterm-born) and n = 53 controls (n = 32 term-born; n = 21 preterm-born). In term-born participants, LV mass to end-diastolic volume ratio decreased (−3.43; 95% CI: −6.29 to −0.56; interaction P = 0.027) and RV stroke volume index increased (5.53 mL/m2; 95% CI: 2.60, 8.47; interaction P = 0.076) for those in the exercise intervention group vs controls. No significant effects were observed for cardiac structural indices in preterm-born participants. In preterm-born participants, LV basal- and mid-ventricular circumferential strain increased (−1.33; 95% CI: −2.07 to −0.60; interaction P = 0.057 and −1.54; 95% CI: −2.46 to −0.63; interaction P = 0.046, respectively) and RV global longitudinal strain increased (1.99%; 95% CI: −3.12 to −0.87; interaction P = 0.053) in the exercise intervention group vs controls. No significant effects were observed for myocardial deformation parameters in term-born participants. Aerobic exercise training induces improved myocardial function but not cardiac structure in preterm-born adults. [Display omitted] |
| ArticleNumber | 101721 |
| Author | Alsharqi, Maryam McCourt, Annabelle Lewandowski, Adam J. Foster, Charlie Lapidaire, Winok Dawes, Helen Tan, Cheryl M.J. Dockerill, Cameron Biasiolli, Luca Woodward, William Mohamed, Afifah Burchert, Holger Burden, Samuel Huckstep, Odaro J. Williamson, Wilby Kenworthy, Yvonne Leeson, Paul |
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| Keywords | preterm birth SBP blood pressure cardiovascular disease RV ECG CMR LV SSFP FDR cardiac remodeling exercise intervention hypertension BMI right ventricular body mass index systolic blood pressure steady-state free precession cardiovascular magnetic resonance imaging electrocardiogram left ventricular false discovery rate |
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| References | Bertagnolli, Huyard, Cloutier (bib19) 2014; 63 Luo, Cheng, Zhang (bib10) 2020; 370 Crump, Sundquist, Sundquist (bib2) 2020; 41 Williamson, Foster, Reid (bib12) 2016; 68 Bensley, Stacy, De Matteo, Harding, Black (bib20) 2010; 31 Huckstep, Williamson, Telles (bib25) 2018; 71 Barton, Corrado, Francois (bib27) 2021; 10 Lewandowski, Levy, Bates, McNamara, Nuyt, Goss (bib23) 2020; 76 Bertagnolli, Dios, Béland-Bonenfant (bib22) 2016; 67 Lønnebakken, Izzo, Mancusi (bib8) 2017; 6 Williamson, Huckstep, Frangou (bib13) 2018; 18 Tan, Lewandowski (bib18) 2020; 47 Mohamed, Marciniak, Williamson (bib6) 2021; 6 Mohamed, Lamata, Williamson (bib16) 2020; 13 Mannakkara, Finocchiaro (bib11) 2023; 24 Ohuma, Moller, Bradley (bib1) 2023; 402 Pucci, Cheriyan, Hubsch (bib15) 2013; 31 Crump, Howell, Stroustrup, McLaughlin, Sundquist, Sundquist (bib4) 2019; 173 Crump (bib5) 2020; 40 Williamson, Lewandowski, Huckstep (bib14) 2022; 48 Crump, Groves, Sundquist, Sundquist (bib3) 2021; 175 Yildiz, Oktay, Stewart, Milani, Ventura, Lavie (bib9) 2020; 63 Bertagnolli, Dartora, Lamata (bib21) 2022; 79 Leeson, Lewandowski (bib24) 2017; 69 Burchert, Lapidaire, Williamson (bib28) 2022; 207 Goss, Beshish, Barton (bib26) 2018; 198 Raisi-Estabragh, Biasiolli, Cooper (bib17) 2020; 36 Telles, McNamara, Nanayakkara (bib7) 2020; 146 Hanssen, Boardman, Deiseroth (bib29) 2021; 29 Ohuma (10.1016/j.jacadv.2025.101721_bib1) 2023; 402 Bertagnolli (10.1016/j.jacadv.2025.101721_bib22) 2016; 67 Crump (10.1016/j.jacadv.2025.101721_bib2) 2020; 41 Mohamed (10.1016/j.jacadv.2025.101721_bib16) 2020; 13 Yildiz (10.1016/j.jacadv.2025.101721_bib9) 2020; 63 Crump (10.1016/j.jacadv.2025.101721_bib5) 2020; 40 Bertagnolli (10.1016/j.jacadv.2025.101721_bib19) 2014; 63 Luo (10.1016/j.jacadv.2025.101721_bib10) 2020; 370 Crump (10.1016/j.jacadv.2025.101721_bib4) 2019; 173 Hanssen (10.1016/j.jacadv.2025.101721_bib29) 2021; 29 Crump (10.1016/j.jacadv.2025.101721_bib3) 2021; 175 Telles (10.1016/j.jacadv.2025.101721_bib7) 2020; 146 Pucci (10.1016/j.jacadv.2025.101721_bib15) 2013; 31 Lewandowski (10.1016/j.jacadv.2025.101721_bib23) 2020; 76 Williamson (10.1016/j.jacadv.2025.101721_bib12) 2016; 68 Bertagnolli (10.1016/j.jacadv.2025.101721_bib21) 2022; 79 Huckstep (10.1016/j.jacadv.2025.101721_bib25) 2018; 71 Barton (10.1016/j.jacadv.2025.101721_bib27) 2021; 10 Leeson (10.1016/j.jacadv.2025.101721_bib24) 2017; 69 Raisi-Estabragh (10.1016/j.jacadv.2025.101721_bib17) 2020; 36 Goss (10.1016/j.jacadv.2025.101721_bib26) 2018; 198 Lønnebakken (10.1016/j.jacadv.2025.101721_bib8) 2017; 6 Mannakkara (10.1016/j.jacadv.2025.101721_bib11) 2023; 24 Tan (10.1016/j.jacadv.2025.101721_bib18) 2020; 47 Burchert (10.1016/j.jacadv.2025.101721_bib28) 2022; 207 Bensley (10.1016/j.jacadv.2025.101721_bib20) 2010; 31 Williamson (10.1016/j.jacadv.2025.101721_bib13) 2018; 18 Mohamed (10.1016/j.jacadv.2025.101721_bib6) 2021; 6 Williamson (10.1016/j.jacadv.2025.101721_bib14) 2022; 48 |
| References_xml | – volume: 31 start-page: 77 year: 2013 end-page: 85 ident: bib15 article-title: Evaluation of the Vicorder, a novel cuff-based device for the noninvasive estimation of central blood pressure publication-title: J Hypertens – volume: 48 year: 2022 ident: bib14 article-title: Effect of moderate to high intensity aerobic exercise on blood pressure in young adults: the TEPHRA open, two-arm, parallel superiority randomized clinical trial publication-title: EClinicalMedicine – volume: 207 start-page: 1227 year: 2022 end-page: 1236 ident: bib28 article-title: Aerobic exercise training response in preterm-born young adults with elevated blood pressure and stage 1 hypertension: a randomised controlled trial publication-title: Am J Respir Crit Care Med – volume: 29 start-page: 205 year: 2021 end-page: 215 ident: bib29 article-title: Personalized exercise prescription in the prevention and treatment of arterial hypertension: a consensus document from the European Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension publication-title: Eur J Prev Cardiol – volume: 67 start-page: 774 year: 2016 end-page: 782 ident: bib22 article-title: Activation of the cardiac renin-angiotensin system in high oxygen-exposed newborn rats: angiotensin receptor blockade prevents the developmental programming of cardiac dysfunction publication-title: Hypertension – volume: 146 year: 2020 ident: bib7 article-title: Changes in the preterm heart from birth to young adulthood: a meta-analysis publication-title: Pediatrics – volume: 31 start-page: 2058 year: 2010 end-page: 2066 ident: bib20 article-title: Cardiac remodelling as a result of pre-term birth: implications for future cardiovascular disease publication-title: Eur Heart J – volume: 76 start-page: 1028 year: 2020 end-page: 1037 ident: bib23 article-title: Impact of the vulnerable preterm heart and circulation on adult cardiovascular disease risk publication-title: Hypertension – volume: 63 start-page: 10 year: 2020 end-page: 21 ident: bib9 article-title: Left ventricular hypertrophy and hypertension publication-title: Prog Cardiovasc Dis – volume: 6 start-page: 821 year: 2021 ident: bib6 article-title: Association of systolic blood pressure elevation with disproportionate left ventricular remodeling in very preterm-born young adults publication-title: JAMA Cardiol – volume: 175 start-page: 689 year: 2021 end-page: 697 ident: bib3 article-title: Association of preterm birth with long-term risk of heart failure into adulthood publication-title: JAMA Pediatr – volume: 68 start-page: 78 year: 2016 end-page: 87 ident: bib12 article-title: Will exercise advice Be sufficient for treatment of young adults with prehypertension and hypertension? A systematic review and meta-analysis publication-title: Hypertension – volume: 402 start-page: 1261 year: 2023 end-page: 1271 ident: bib1 article-title: National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis publication-title: Lancet – volume: 370 year: 2020 ident: bib10 article-title: Association between high blood pressure and long term cardiovascular events in young adults: systematic review and meta-analysis publication-title: BMJ – volume: 47 start-page: 373 year: 2020 end-page: 386 ident: bib18 article-title: The transitional heart: from early embryonic and fetal development to neonatal life publication-title: Fetal Diagn Ther – volume: 198 start-page: 1549 year: 2018 end-page: 1558 ident: bib26 article-title: Early pulmonary vascular disease in young adults born preterm publication-title: Am J Respir Crit Care Med – volume: 79 start-page: 1789 year: 2022 end-page: 1803 ident: bib21 article-title: Reshaping the preterm heart: shifting cardiac renin-angiotensin system towards cardioprotection in rats exposed to neonatal high-oxygen stress publication-title: Hypertension – volume: 6 year: 2017 ident: bib8 article-title: Left ventricular hypertrophy regression during antihypertensive treatment in an outpatient clinic (the Campania Salute Network) publication-title: J Am Heart Assoc – volume: 173 start-page: 736 year: 2019 ident: bib4 article-title: Association of preterm birth with risk of ischemic heart disease in adulthood publication-title: JAMA Pediatr – volume: 69 start-page: 2643 year: 2017 end-page: 2645 ident: bib24 article-title: A new risk factor for early heart failure: preterm birth publication-title: J Am Coll Cardiol – volume: 41 start-page: 1542 year: 2020 end-page: 1550 ident: bib2 article-title: Risk of hypertension into adulthood in persons born prematurely: a national cohort study publication-title: Eur Heart J – volume: 63 start-page: 143 year: 2014 end-page: 150 ident: bib19 article-title: Transient neonatal high oxygen exposure leads to early adult cardiac dysfunction, remodeling, and activation of the renin-angiotensin system publication-title: Hypertension – volume: 10 start-page: 1166 year: 2021 ident: bib27 article-title: Exaggerated cardiac contractile response to hypoxia in adults born preterm publication-title: J Clin Med – volume: 36 start-page: 90 year: 2020 end-page: 99 ident: bib17 article-title: Poor bone quality is associated with greater arterial stiffness: insights from the UK Biobank publication-title: J Bone Mineral Res – volume: 24 start-page: 94 year: 2023 ident: bib11 article-title: Exercise and the heart: benefits, risks and adverse effects of exercise training publication-title: Rev Cardiovasc Med – volume: 18 start-page: 208 year: 2018 ident: bib13 article-title: Trial of exercise to prevent HypeRtension in young adults (TEPHRA) a randomized controlled trial: study protocol publication-title: BMC Cardiovasc Disord – volume: 71 start-page: 1347 year: 2018 end-page: 1356 ident: bib25 article-title: Physiological stress elicits impaired left ventricular function in preterm-born adults publication-title: J Am Coll Cardiol – volume: 40 start-page: 833 year: 2020 end-page: 843 ident: bib5 article-title: Preterm birth and mortality in adulthood: a systematic review publication-title: J Perinatol – volume: 13 start-page: 2046 year: 2020 end-page: 2048 ident: bib16 article-title: Multimodality imaging demonstrates reduced right-ventricular function independent of pulmonary physiology in moderately preterm-born adults publication-title: JACC Cardiovasc Imaging – volume: 68 start-page: 78 issue: 1 year: 2016 ident: 10.1016/j.jacadv.2025.101721_bib12 article-title: Will exercise advice Be sufficient for treatment of young adults with prehypertension and hypertension? A systematic review and meta-analysis publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.116.07431 – volume: 71 start-page: 1347 issue: 12 year: 2018 ident: 10.1016/j.jacadv.2025.101721_bib25 article-title: Physiological stress elicits impaired left ventricular function in preterm-born adults publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2018.01.046 – volume: 31 start-page: 2058 issue: 16 year: 2010 ident: 10.1016/j.jacadv.2025.101721_bib20 article-title: Cardiac remodelling as a result of pre-term birth: implications for future cardiovascular disease publication-title: Eur Heart J doi: 10.1093/eurheartj/ehq104 – volume: 69 start-page: 2643 issue: 21 year: 2017 ident: 10.1016/j.jacadv.2025.101721_bib24 article-title: A new risk factor for early heart failure: preterm birth publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2017.03.574 – volume: 76 start-page: 1028 issue: 4 year: 2020 ident: 10.1016/j.jacadv.2025.101721_bib23 article-title: Impact of the vulnerable preterm heart and circulation on adult cardiovascular disease risk publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.120.15574 – volume: 198 start-page: 1549 issue: 12 year: 2018 ident: 10.1016/j.jacadv.2025.101721_bib26 article-title: Early pulmonary vascular disease in young adults born preterm publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201710-2016OC – volume: 40 start-page: 833 issue: 6 year: 2020 ident: 10.1016/j.jacadv.2025.101721_bib5 article-title: Preterm birth and mortality in adulthood: a systematic review publication-title: J Perinatol doi: 10.1038/s41372-019-0563-y – volume: 47 start-page: 373 issue: 5 year: 2020 ident: 10.1016/j.jacadv.2025.101721_bib18 article-title: The transitional heart: from early embryonic and fetal development to neonatal life publication-title: Fetal Diagn Ther doi: 10.1159/000501906 – volume: 67 start-page: 774 issue: 4 year: 2016 ident: 10.1016/j.jacadv.2025.101721_bib22 article-title: Activation of the cardiac renin-angiotensin system in high oxygen-exposed newborn rats: angiotensin receptor blockade prevents the developmental programming of cardiac dysfunction publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.115.06745 – volume: 79 start-page: 1789 issue: 8 year: 2022 ident: 10.1016/j.jacadv.2025.101721_bib21 article-title: Reshaping the preterm heart: shifting cardiac renin-angiotensin system towards cardioprotection in rats exposed to neonatal high-oxygen stress publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.122.19115 – volume: 63 start-page: 10 issue: 1 year: 2020 ident: 10.1016/j.jacadv.2025.101721_bib9 article-title: Left ventricular hypertrophy and hypertension publication-title: Prog Cardiovasc Dis doi: 10.1016/j.pcad.2019.11.009 – volume: 402 start-page: 1261 issue: 10409 year: 2023 ident: 10.1016/j.jacadv.2025.101721_bib1 article-title: National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis publication-title: Lancet doi: 10.1016/S0140-6736(23)00878-4 – volume: 41 start-page: 1542 issue: 16 year: 2020 ident: 10.1016/j.jacadv.2025.101721_bib2 article-title: Risk of hypertension into adulthood in persons born prematurely: a national cohort study publication-title: Eur Heart J doi: 10.1093/eurheartj/ehz904 – volume: 24 start-page: 94 issue: 3 year: 2023 ident: 10.1016/j.jacadv.2025.101721_bib11 article-title: Exercise and the heart: benefits, risks and adverse effects of exercise training publication-title: Rev Cardiovasc Med doi: 10.31083/j.rcm2403094 – volume: 175 start-page: 689 issue: 7 year: 2021 ident: 10.1016/j.jacadv.2025.101721_bib3 article-title: Association of preterm birth with long-term risk of heart failure into adulthood publication-title: JAMA Pediatr doi: 10.1001/jamapediatrics.2021.0131 – volume: 13 start-page: 2046 issue: 9 year: 2020 ident: 10.1016/j.jacadv.2025.101721_bib16 article-title: Multimodality imaging demonstrates reduced right-ventricular function independent of pulmonary physiology in moderately preterm-born adults publication-title: JACC Cardiovasc Imaging doi: 10.1016/j.jcmg.2020.03.016 – volume: 6 issue: 3 year: 2017 ident: 10.1016/j.jacadv.2025.101721_bib8 article-title: Left ventricular hypertrophy regression during antihypertensive treatment in an outpatient clinic (the Campania Salute Network) publication-title: J Am Heart Assoc doi: 10.1161/JAHA.116.004152 – volume: 10 start-page: 1166 issue: 6 year: 2021 ident: 10.1016/j.jacadv.2025.101721_bib27 article-title: Exaggerated cardiac contractile response to hypoxia in adults born preterm publication-title: J Clin Med doi: 10.3390/jcm10061166 – volume: 18 start-page: 208 year: 2018 ident: 10.1016/j.jacadv.2025.101721_bib13 article-title: Trial of exercise to prevent HypeRtension in young adults (TEPHRA) a randomized controlled trial: study protocol publication-title: BMC Cardiovasc Disord doi: 10.1186/s12872-018-0944-8 – volume: 146 issue: 2 year: 2020 ident: 10.1016/j.jacadv.2025.101721_bib7 article-title: Changes in the preterm heart from birth to young adulthood: a meta-analysis publication-title: Pediatrics doi: 10.1542/peds.2020-0146 – volume: 207 start-page: 1227 issue: 9 year: 2022 ident: 10.1016/j.jacadv.2025.101721_bib28 article-title: Aerobic exercise training response in preterm-born young adults with elevated blood pressure and stage 1 hypertension: a randomised controlled trial publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.202205-0858OC – volume: 63 start-page: 143 issue: 1 year: 2014 ident: 10.1016/j.jacadv.2025.101721_bib19 article-title: Transient neonatal high oxygen exposure leads to early adult cardiac dysfunction, remodeling, and activation of the renin-angiotensin system publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.113.01760 – volume: 173 start-page: 736 issue: 8 year: 2019 ident: 10.1016/j.jacadv.2025.101721_bib4 article-title: Association of preterm birth with risk of ischemic heart disease in adulthood publication-title: JAMA Pediatr doi: 10.1001/jamapediatrics.2019.1327 – volume: 6 start-page: 821 issue: 7 year: 2021 ident: 10.1016/j.jacadv.2025.101721_bib6 article-title: Association of systolic blood pressure elevation with disproportionate left ventricular remodeling in very preterm-born young adults publication-title: JAMA Cardiol doi: 10.1001/jamacardio.2021.0961 – volume: 31 start-page: 77 issue: 1 year: 2013 ident: 10.1016/j.jacadv.2025.101721_bib15 article-title: Evaluation of the Vicorder, a novel cuff-based device for the noninvasive estimation of central blood pressure publication-title: J Hypertens doi: 10.1097/HJH.0b013e32835a8eb1 – volume: 36 start-page: 90 issue: 1 year: 2020 ident: 10.1016/j.jacadv.2025.101721_bib17 article-title: Poor bone quality is associated with greater arterial stiffness: insights from the UK Biobank publication-title: J Bone Mineral Res doi: 10.1002/jbmr.4164 – volume: 370 year: 2020 ident: 10.1016/j.jacadv.2025.101721_bib10 article-title: Association between high blood pressure and long term cardiovascular events in young adults: systematic review and meta-analysis publication-title: BMJ – volume: 48 year: 2022 ident: 10.1016/j.jacadv.2025.101721_bib14 article-title: Effect of moderate to high intensity aerobic exercise on blood pressure in young adults: the TEPHRA open, two-arm, parallel superiority randomized clinical trial publication-title: EClinicalMedicine doi: 10.1016/j.eclinm.2022.101445 – volume: 29 start-page: 205 issue: 1 year: 2021 ident: 10.1016/j.jacadv.2025.101721_bib29 article-title: Personalized exercise prescription in the prevention and treatment of arterial hypertension: a consensus document from the European Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension publication-title: Eur J Prev Cardiol doi: 10.1093/eurjpc/zwaa141 |
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| Snippet | People born preterm (<37 weeks' gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation.
The authors investigated... AbstractBackgroundPeople born preterm (<37 weeks' gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation.... Background: People born preterm (<37 weeks' gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation. Objectives:... |
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| SubjectTerms | blood pressure cardiac remodeling Cardiovascular cardiovascular disease exercise intervention hypertension preterm birth |
| Title | Exercise Improves Myocardial Deformation But Not Cardiac Structure in Preterm-Born Adults |
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